SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1kjw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_A_SALA710_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 1kjw POSTSYNAPTIC DENSITY
PROTEIN 95
(Rattus
norvegicus) 		4 / 7 ARG A 637
VAL A 616
ALA A 641
LEU A 638
 None
 0.89A 1pthA-1kjwA:
0.0		 1pthA-1kjwA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_B_SALB711_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 1kjw POSTSYNAPTIC DENSITY
PROTEIN 95
(Rattus
norvegicus) 		4 / 7 ARG A 637
VAL A 616
ALA A 641
LEU A 638
 None
 0.88A 1pthB-1kjwA:
0.0		 1pthB-1kjwA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA1001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 1kjw POSTSYNAPTIC DENSITY
PROTEIN 95
(Rattus
norvegicus) 		4 / 5 LEU A 540
GLY A 541
PHE A 649
PHE A 688
 None
 1.11A 3smtA-1kjwA:
undetectable		 3smtA-1kjwA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_A_LNLA701_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1kjw POSTSYNAPTIC DENSITY
PROTEIN 95
(Rattus
norvegicus) 		4 / 5 ARG A 497
VAL A 520
LEU A 521
SER A 522
 None
 0.74A 4e1gA-1kjwA:
undetectable		 4e1gA-1kjwA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_A_TKTA508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 1kjw POSTSYNAPTIC DENSITY
PROTEIN 95
(Rattus
norvegicus) 		4 / 8 TRP A 471
ARG A 493
ARG A 496
TYR A 439
 None
 1.22A 6hisA-1kjwA:
0.0
6hisB-1kjwA:
0.0		 6hisA-1kjwA:
22.56
6hisB-1kjwA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_B_TKTB508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 1kjw POSTSYNAPTIC DENSITY
PROTEIN 95
(Rattus
norvegicus) 		4 / 8 TRP A 471
ARG A 493
ARG A 496
TYR A 439
 None
 1.22A 6hisB-1kjwA:
0.0
6hisC-1kjwA:
0.0		 6hisB-1kjwA:
22.56
6hisC-1kjwA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_C_TKTC508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 1kjw POSTSYNAPTIC DENSITY
PROTEIN 95
(Rattus
norvegicus) 		4 / 8 TRP A 471
ARG A 493
ARG A 496
TYR A 439
 None
 1.21A 6hisC-1kjwA:
0.0
6hisD-1kjwA:
0.0		 6hisC-1kjwA:
22.56
6hisD-1kjwA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_D_TKTD501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 1kjw POSTSYNAPTIC DENSITY
PROTEIN 95
(Rattus
norvegicus) 		4 / 8 TRP A 471
ARG A 493
ARG A 496
TYR A 439
 None
 1.23A 6hisD-1kjwA:
0.0
6hisE-1kjwA:
0.0		 6hisD-1kjwA:
22.56
6hisE-1kjwA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_E_TKTE501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 1kjw POSTSYNAPTIC DENSITY
PROTEIN 95
(Rattus
norvegicus) 		4 / 8 TYR A 439
TRP A 471
ARG A 493
ARG A 496
 None
 1.22A 6hisA-1kjwA:
0.0
6hisE-1kjwA:
undetectable		 6hisA-1kjwA:
22.56
6hisE-1kjwA:
22.56