SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1kk0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PIV_A_T3A933_1
(ANDROGEN RECEPTOR)		 1kk0 EIF2GAMMA
(Pyrococcus
abyssi) 		5 / 9 PRO A 199
ILE A 198
PHE A 197
GLU A 172
ASN A 173
 None
 1.16A 2pivA-1kk0A:
0.0		 2pivA-1kk0A:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN1_A_FK5A501_2
(70 KDA
PEPTIDYLPROLYL
ISOMERASE)		 1kk0 EIF2GAMMA
(Pyrococcus
abyssi) 		4 / 6 LEU A  96
SER A  86
PHE A  52
ASP A  54
 None
 1.24A 2vn1B-1kk0A:
undetectable		 2vn1B-1kk0A:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1414_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 1kk0 EIF2GAMMA
(Pyrococcus
abyssi) 		5 / 8 MET A  97
HIS A  93
ILE A 114
LEU A 112
LEU A 129
 None
 1.48A 2xfhA-1kk0A:
undetectable		 2xfhA-1kk0A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1kk0 EIF2GAMMA
(Pyrococcus
abyssi) 		4 / 8 THR A  79
SER A  67
TYR A  74
CYH A  63
 None
None
None
ZN  A 411 (-2.2A)
 1.39A 2xz5A-1kk0A:
0.0
2xz5C-1kk0A:
0.0		 2xz5A-1kk0A:
19.75
2xz5C-1kk0A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZU_A_9CRA7223_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1kk0 EIF2GAMMA
(Pyrococcus
abyssi) 		5 / 12 ILE A 179
ALA A 181
ASN A 158
ILE A 114
LEU A  26
 None
 1.13A 3dzuA-1kk0A:
undetectable		 3dzuA-1kk0A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HRD_B_NIOB5661_1
(NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT)		 1kk0 EIF2GAMMA
(Pyrococcus
abyssi) 		4 / 8 ILE A  48
ALA A 102
ARG A 389
LEU A 106
 None
 0.95A 3hrdA-1kk0A:
0.0
3hrdB-1kk0A:
0.0		 3hrdA-1kk0A:
22.69
3hrdB-1kk0A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_C_DX2C270_1
(PTERIDINE REDUCTASE
1)		 1kk0 EIF2GAMMA
(Pyrococcus
abyssi) 		4 / 8 SER A 105
VAL A 312
LEU A 318
PRO A 319
 None
 1.10A 3jq7C-1kk0A:
3.6		 3jq7C-1kk0A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAT_A_BEZA1000_0
(BENZOATE-COENZYME A
LIGASE)		 1kk0 EIF2GAMMA
(Pyrococcus
abyssi) 		4 / 7 ALA A 185
GLY A 184
ILE A 179
ILE A 147
 None
 0.68A 4eatA-1kk0A:
2.8		 4eatA-1kk0A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_B_ECNB403_1
(FLAVOHEMOGLOBIN)		 1kk0 EIF2GAMMA
(Pyrococcus
abyssi) 		5 / 11 ILE A 134
ALA A 102
LEU A 101
THR A  98
LEU A 332
 None
 1.08A 4g1bB-1kk0A:
3.6		 4g1bB-1kk0A:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_A_IMNA502_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1kk0 EIF2GAMMA
(Pyrococcus
abyssi) 		4 / 7 GLU A  10
ILE A  57
LEU A  26
ILE A  13
 None
 0.94A 4xumA-1kk0A:
undetectable		 4xumA-1kk0A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_B_OAQB302_0
(SULFOTRANSFERASE)		 1kk0 EIF2GAMMA
(Pyrococcus
abyssi) 		5 / 12 ASP A 108
ILE A  48
PHE A  52
SER A 237
LEU A  96
 None
 1.29A 5tiwB-1kk0A:
1.2		 5tiwB-1kk0A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW4_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 1kk0 EIF2GAMMA
(Pyrococcus
abyssi) 		5 / 9 THR A 359
ALA A 360
GLY A 103
LEU A 106
SER A 105
 None
 1.08A 5vw4A-1kk0A:
3.1		 5vw4A-1kk0A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7B_B_PA1B204_1
(ACYLOXYACYL
HYDROLASE SMALL
SUBUNIT
ACYLOXYACYL
HYDROLASE LARGE
SUBUNIT)		 1kk0 EIF2GAMMA
(Pyrococcus
abyssi) 		3 / 3 GLY A 289
ASN A  12
ARG A 203
 None
 0.74A 5w7bD-1kk0A:
4.2		 5w7bD-1kk0A:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_E_EY4E500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 1kk0 EIF2GAMMA
(Pyrococcus
abyssi) 		4 / 8 ILE A 198
VAL A  85
ALA A  55
THR A  31
 None
 0.91A 6cduD-1kk0A:
undetectable
6cduE-1kk0A:
undetectable		 6cduD-1kk0A:
21.28
6cduE-1kk0A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_F_EY4F500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 1kk0 EIF2GAMMA
(Pyrococcus
abyssi) 		4 / 7 ALA A  55
THR A  31
ILE A 198
VAL A  85
 None
 0.96A 6cduF-1kk0A:
undetectable
6cduJ-1kk0A:
undetectable		 6cduF-1kk0A:
21.28
6cduJ-1kk0A:
21.28