SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1kke'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 1kke SIGMA 1 PROTEIN
(Mammalian
orthoreovirus) 		5 / 11 GLY A 330
HIS A 438
GLY A 363
ASP A 362
ILE A 401
 None
 1.12A 1jzsA-1kkeA:
undetectable		 1jzsA-1kkeA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_C_URFC999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 1kke SIGMA 1 PROTEIN
(Mammalian
orthoreovirus) 		4 / 5 MET A 309
ALA A 301
TYR A 298
ILE A 300
 None
 1.16A 1upfC-1kkeA:
undetectable		 1upfC-1kkeA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_D_URFD999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 1kke SIGMA 1 PROTEIN
(Mammalian
orthoreovirus) 		4 / 4 MET A 309
ALA A 301
TYR A 298
ILE A 300
 None
 1.18A 1upfD-1kkeA:
undetectable		 1upfD-1kkeA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA607_1
(CHITINASE A)		 1kke SIGMA 1 PROTEIN
(Mammalian
orthoreovirus) 		4 / 7 VAL A 337
SER A 339
LEU A 368
TRP A 333
 None
 1.20A 3arrA-1kkeA:
undetectable		 3arrA-1kkeA:
15.85