SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1kkh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_F_AG2F7016_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 1kkh MEVALONATE KINASE
(Methanocaldococc
us
jannaschii) 		4 / 8 LEU A 144
GLY A 145
ILE A 122
GLU A 135
 None
 0.81A 1n13A-1kkhA:
undetectable
1n13F-1kkhA:
undetectable		 1n13A-1kkhA:
10.78
1n13F-1kkhA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_A_9CRA131_1
(TRANSTHYRETIN)		 1kkh MEVALONATE KINASE
(Methanocaldococc
us
jannaschii) 		4 / 6 LYS A  86
ALA A  84
LEU A 144
THR A 121
 None
 1.27A 1tyrA-1kkhA:
undetectable		 1tyrA-1kkhA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_A_CQAA403_0
(HISTAMINE
N-METHYLTRANSFERASE)		 1kkh MEVALONATE KINASE
(Methanocaldococc
us
jannaschii) 		4 / 8 ASP A 139
LYS A 143
GLY A 145
THR A  10
 None
 1.00A 2aouA-1kkhA:
undetectable		 2aouA-1kkhA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_B_AG2B671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1kkh MEVALONATE KINASE
(Methanocaldococc
us
jannaschii) 		4 / 8 ILE A 122
GLU A 135
LEU A 144
GLY A 145
 None
 0.75A 2qqdB-1kkhA:
undetectable
2qqdC-1kkhA:
undetectable		 2qqdB-1kkhA:
17.10
2qqdC-1kkhA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 1kkh MEVALONATE KINASE
(Methanocaldococc
us
jannaschii) 		5 / 12 ALA A 127
VAL A 128
THR A  44
ILE A  49
PHE A 100
 None
 1.27A 2v95A-1kkhA:
0.0		 2v95A-1kkhA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 1kkh MEVALONATE KINASE
(Methanocaldococc
us
jannaschii) 		5 / 12 SER A 129
VAL A 128
THR A  44
ILE A 102
PHE A 100
 None
 1.39A 2vdyA-1kkhA:
0.0		 2vdyA-1kkhA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1kkh MEVALONATE KINASE
(Methanocaldococc
us
jannaschii) 		4 / 6 LEU A 233
ARG A  27
ILE A  29
ILE A 164
 None
 0.85A 2xkwB-1kkhA:
undetectable		 2xkwB-1kkhA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_B_VDNB1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1kkh MEVALONATE KINASE
(Methanocaldococc
us
jannaschii) 		5 / 11 ILE A  49
LEU A  82
ALA A  84
VAL A 128
ILE A  94
 None
 1.12A 3b2rB-1kkhA:
undetectable		 3b2rB-1kkhA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_0
(PUTATIVE RRNA
METHYLASE)		 1kkh MEVALONATE KINASE
(Methanocaldococc
us
jannaschii) 		5 / 12 ASP A  90
ASN A  87
LEU A  82
PRO A  72
THR A 121
 None
 1.00A 3eeyD-1kkhA:
undetectable		 3eeyD-1kkhA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_0
(PUTATIVE RRNA
METHYLASE)		 1kkh MEVALONATE KINASE
(Methanocaldococc
us
jannaschii) 		5 / 12 ASP A  90
ILE A 102
ASN A  87
LEU A  82
PRO A  72
 None
 0.85A 3eeyD-1kkhA:
undetectable		 3eeyD-1kkhA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_F_H3PF552_1
(GLUTAMATE
DEHYDROGENASE)		 1kkh MEVALONATE KINASE
(Methanocaldococc
us
jannaschii) 		4 / 7 LYS A 227
HIS A 249
LYS A 253
ILE A 221
 None
 0.80A 3eteD-1kkhA:
undetectable
3eteF-1kkhA:
0.6		 3eteD-1kkhA:
22.85
3eteF-1kkhA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_B_TMQB612_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1kkh MEVALONATE KINASE
(Methanocaldococc
us
jannaschii) 		5 / 9 VAL A 128
ALA A  84
ILE A 120
THR A  10
SER A  37
 None
 1.28A 3hbbB-1kkhA:
undetectable		 3hbbB-1kkhA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_Q_TFPQ201_1
(PROTEIN S100-A4)		 1kkh MEVALONATE KINASE
(Methanocaldococc
us
jannaschii) 		4 / 8 GLY A 242
PHE A 241
ILE A 225
PHE A 184
 None
 0.84A 3ko0O-1kkhA:
undetectable
3ko0Q-1kkhA:
0.5		 3ko0O-1kkhA:
17.39
3ko0Q-1kkhA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUG_A_SUEA1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 1kkh MEVALONATE KINASE
(Methanocaldococc
us
jannaschii) 		4 / 5 GLN A 153
TYR A 146
LEU A  82
LYS A  79
 None
 1.42A 3sugA-1kkhA:
undetectable		 3sugA-1kkhA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_A_P1BA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 1kkh MEVALONATE KINASE
(Methanocaldococc
us
jannaschii) 		5 / 12 PRO A  96
LEU A  89
LEU A  82
CYH A  81
ILE A  49
 None
 1.48A 4a79A-1kkhA:
undetectable		 4a79A-1kkhA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 1kkh MEVALONATE KINASE
(Methanocaldococc
us
jannaschii) 		5 / 12 SER A 129
VAL A 128
THR A  44
ILE A 102
PHE A 100
 None
 1.38A 4c49B-1kkhA:
0.0		 4c49B-1kkhA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_C_HCYC1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 1kkh MEVALONATE KINASE
(Methanocaldococc
us
jannaschii) 		5 / 12 SER A 129
VAL A 128
THR A  44
ILE A 102
PHE A 100
 None
 1.35A 4c49C-1kkhA:
0.0		 4c49C-1kkhA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_D_HCYD1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 1kkh MEVALONATE KINASE
(Methanocaldococc
us
jannaschii) 		5 / 12 SER A 129
VAL A 128
THR A  44
ILE A 102
PHE A 100
 None
 1.40A 4c49D-1kkhA:
0.0		 4c49D-1kkhA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		 1kkh MEVALONATE KINASE
(Methanocaldococc
us
jannaschii) 		4 / 6 LYS A  86
ALA A  84
LEU A 144
THR A 121
 None
 1.21A 4d7bB-1kkhA:
0.0		 4d7bB-1kkhA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAJ_B_0HKB2000_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR M3,
LYSOZYME)		 1kkh MEVALONATE KINASE
(Methanocaldococc
us
jannaschii) 		3 / 3 ASN A 270
LEU A 303
PHE A 274
 None
 0.71A 4dajB-1kkhA:
undetectable		 4dajB-1kkhA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HB8_A_DXCA75_0
(PPCA)		 1kkh MEVALONATE KINASE
(Methanocaldococc
us
jannaschii) 		4 / 8 ILE A 288
LEU A  16
LYS A 189
GLY A 168
 None
 0.84A 4hb8A-1kkhA:
undetectable		 4hb8A-1kkhA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA505_0
(RNA POLYMERASE
3D-POL)		 1kkh MEVALONATE KINASE
(Methanocaldococc
us
jannaschii) 		3 / 3 CYH A  83
ASN A  71
LYS A  79
 None
 1.34A 4k50A-1kkhA:
0.2		 4k50A-1kkhA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UYM_B_VORB590_1
(14-ALPHA STEROL
DEMETHYLASE)		 1kkh MEVALONATE KINASE
(Methanocaldococc
us
jannaschii) 		4 / 7 ALA A 232
ILE A 180
LEU A 188
PHE A 184
 None
 0.99A 4uymB-1kkhA:
0.0		 4uymB-1kkhA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_A_0HKA1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 1kkh MEVALONATE KINASE
(Methanocaldococc
us
jannaschii) 		3 / 3 ASN A 270
LEU A 303
PHE A 274
 None
 0.68A 5dsgA-1kkhA:
undetectable		 5dsgA-1kkhA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_W_BEZW801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1kkh MEVALONATE KINASE
(Methanocaldococc
us
jannaschii) 		5 / 5 PHE A 100
ILE A  67
GLY A  99
ILE A  85
LEU A  64
 None
 1.41A 5dzkB-1kkhA:
undetectable
5dzkI-1kkhA:
undetectable
5dzkW-1kkhA:
undetectable		 5dzkB-1kkhA:
19.09
5dzkI-1kkhA:
22.33
5dzkW-1kkhA:
0.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Y_BEZY801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1kkh MEVALONATE KINASE
(Methanocaldococc
us
jannaschii) 		5 / 5 PHE A 100
ILE A  67
GLY A  99
ILE A  85
LEU A  64
 None
 1.39A 5dzkd-1kkhA:
undetectable
5dzkk-1kkhA:
0.4
5dzky-1kkhA:
undetectable		 5dzkd-1kkhA:
19.09
5dzkk-1kkhA:
22.33
5dzky-1kkhA:
0.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_A_OAQA302_0
(SULFOTRANSFERASE)		 1kkh MEVALONATE KINASE
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A  67
VAL A 128
ILE A 102
LEU A  62
LEU A  60
 None
 1.03A 5tiwA-1kkhA:
undetectable		 5tiwA-1kkhA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA813_0
(GEPHYRIN)		 1kkh MEVALONATE KINASE
(Methanocaldococc
us
jannaschii) 		3 / 3 THR A 121
ALA A  84
LYS A  86
 None
 0.76A 6fgcA-1kkhA:
0.8		 6fgcA-1kkhA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NCS_A_ACTA303_0
(N-ACETYLNEURAMINIC
ACID (SIALIC ACID)
SYNTHETASE)		 1kkh MEVALONATE KINASE
(Methanocaldococc
us
jannaschii) 		3 / 3 ILE A 164
THR A 163
PRO A  11
 None
 0.56A 6ncsA-1kkhA:
undetectable		 6ncsA-1kkhA:
23.50