SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1kkm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHA_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1kkm HPRK PROTEIN
(Lactobacillus
casei) 		4 / 8 GLY A 172
GLY A 218
PHE A 217
ARG A 174
 None
 0.75A 1jhaA-1kkmA:
undetectable		 1jhaA-1kkmA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KAW_A_SUZA91_1
(SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-1)		 1kkm PHOSPHOCARRIER
PROTEIN HPR
(Bacillus
subtilis) 		5 / 11 LEU H  53
GLY H  54
ILE H  55
VAL H  23
VAL H  42
 None
 0.95A 2kawA-1kkmH:
undetectable		 2kawA-1kkmH:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_4
(PROTEASE RETROPEPSIN)		 1kkm HPRK PROTEIN
PHOSPHOCARRIER
PROTEIN HPR
(Bacillus
subtilis;
Lactobacillus
casei) 		3 / 3 ASP H  30
THR A 238
PRO A 239
 None
 0.68A 2qakB-1kkmH:
undetectable		 2qakB-1kkmH:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_A_CLMA1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 1kkm PHOSPHOCARRIER
PROTEIN HPR
(Bacillus
subtilis) 		5 / 8 ALA H  73
LEU H  22
ILE H  63
VAL H  50
ILE H  47
 None
None
None
SEP  H  46 ( 4.2A)
SEP  H  46 ( 3.5A)
 1.47A 2uxpA-1kkmH:
undetectable		 2uxpA-1kkmH:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_A_CLMA1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 1kkm PHOSPHOCARRIER
PROTEIN HPR
(Bacillus
subtilis) 		5 / 8 ALA H  73
LEU H  77
LEU H  22
VAL H  50
ILE H  47
 None
None
None
SEP  H  46 ( 4.2A)
SEP  H  46 ( 3.5A)
 1.30A 2uxpA-1kkmH:
undetectable		 2uxpA-1kkmH:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZV_A_017A200_2
(HIV-1 PROTEASE)		 1kkm HPRK PROTEIN
(Lactobacillus
casei) 		5 / 11 VAL A 260
ILE A 191
GLY A 193
ILE A 176
ILE A 231
 None
 1.01A 3lzvB-1kkmA:
undetectable		 3lzvB-1kkmA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU6_B_478B401_1
(PROTEASE)		 1kkm HPRK PROTEIN
(Lactobacillus
casei) 		5 / 10 VAL A 260
ILE A 191
GLY A 193
ILE A 176
ILE A 231
 None
 0.96A 3nu6A-1kkmA:
0.0		 3nu6A-1kkmA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUJ_B_478B401_1
(PROTEASE)		 1kkm HPRK PROTEIN
(Lactobacillus
casei) 		5 / 10 VAL A 260
ILE A 191
GLY A 193
ILE A 176
ILE A 231
 None
 1.00A 3nujA-1kkmA:
undetectable		 3nujA-1kkmA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_A_9PLA501_1
(CYTOCHROME P450 2E1)		 1kkm PHOSPHOCARRIER
PROTEIN HPR
(Bacillus
subtilis) 		4 / 6 LEU H  74
PHE H   6
THR H  80
LEU H  44
 None
 0.95A 3t3zA-1kkmH:
undetectable		 3t3zA-1kkmH:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_B_9PLB501_1
(CYTOCHROME P450 2E1)		 1kkm PHOSPHOCARRIER
PROTEIN HPR
(Bacillus
subtilis) 		4 / 6 LEU H  74
PHE H   6
THR H  80
LEU H  44
 None
 0.98A 3t3zB-1kkmH:
undetectable		 3t3zB-1kkmH:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_D_9PLD501_1
(CYTOCHROME P450 2E1)		 1kkm PHOSPHOCARRIER
PROTEIN HPR
(Bacillus
subtilis) 		4 / 6 LEU H  74
PHE H   6
THR H  80
LEU H  44
 None
 0.93A 3t3zD-1kkmH:
undetectable		 3t3zD-1kkmH:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_B_478B101_1
(HIV-1 PROTEASE)		 1kkm HPRK PROTEIN
(Lactobacillus
casei) 		5 / 11 VAL A 260
ILE A 191
GLY A 193
ILE A 176
ILE A 231
 None
 0.98A 4rvjA-1kkmA:
undetectable		 4rvjA-1kkmA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_D_478D101_1
(HIV-1 PROTEASE)		 1kkm HPRK PROTEIN
(Lactobacillus
casei) 		5 / 11 VAL A 260
ILE A 191
GLY A 193
ILE A 176
ILE A 231
 None
 0.99A 4rvjC-1kkmA:
undetectable		 4rvjC-1kkmA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_E_IPHE101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 1kkm HPRK PROTEIN
(Lactobacillus
casei) 		4 / 7 ILE A 211
HIS A 201
LEU A 175
ALA A 221
 None
 0.89A 5hrqE-1kkmA:
undetectable
5hrqF-1kkmA:
undetectable
5hrqJ-1kkmA:
undetectable		 5hrqE-1kkmA:
6.25
5hrqF-1kkmA:
15.62
5hrqJ-1kkmA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ2_B_AB1B201_0
(HIV-1 PROTEASE)		 1kkm HPRK PROTEIN
(Lactobacillus
casei) 		5 / 10 VAL A 260
ILE A 191
GLY A 193
ILE A 176
ILE A 231
 None
 0.96A 6dj2A-1kkmA:
undetectable		 6dj2A-1kkmA:
19.51