SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1kkr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA206_1
(CARDIAC TROPONIN C)		 1kkr 3-METHYLASPARTATE
AMMONIA-LYASE
(Citrobacter
amalonaticus) 		4 / 8 MET A 249
ASP A 283
ARG A 286
MET A 287
 None
 1.11A 1dtlA-1kkrA:
undetectable		 1dtlA-1kkrA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVT_A_FLPA125_1
(TRANSTHYRETIN)		 1kkr 3-METHYLASPARTATE
AMMONIA-LYASE
(Citrobacter
amalonaticus) 		4 / 8 LEU A 235
LEU A 270
LEU A 298
SER A 300
 None
 0.76A 1dvtA-1kkrA:
undetectable
1dvtB-1kkrA:
0.0		 1dvtA-1kkrA:
15.82
1dvtB-1kkrA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S1U_A_NVPA999_1
(REVERSE
TRANSCRIPTASE)		 1kkr 3-METHYLASPARTATE
AMMONIA-LYASE
(Citrobacter
amalonaticus) 		5 / 10 ILE A 258
VAL A 239
VAL A 276
GLY A 241
TYR A 257
 None
 1.24A 1s1uA-1kkrA:
0.0		 1s1uA-1kkrA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_D_IMND476_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 1kkr 3-METHYLASPARTATE
AMMONIA-LYASE
(Citrobacter
amalonaticus) 		5 / 12 ILE A 237
VAL A 239
TYR A 257
ILE A 258
LEU A 204
 None
 1.02A 1z9hD-1kkrA:
undetectable		 1z9hD-1kkrA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q2H_B_ACTB501_0
(SECRETION CHAPERONE,
PHAGE-DISPLAY
DERIVED PEPTIDE)		 1kkr 3-METHYLASPARTATE
AMMONIA-LYASE
(Citrobacter
amalonaticus) 		3 / 3 ARG A 177
SER A 173
TYR A 214
 None
 1.05A 2q2hA-1kkrA:
0.0
2q2hB-1kkrA:
0.0		 2q2hA-1kkrA:
16.58
2q2hB-1kkrA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_A_ACRA5044_2
(GLUCOSYLTRANSFERASE-
SI)		 1kkr 3-METHYLASPARTATE
AMMONIA-LYASE
(Citrobacter
amalonaticus) 		3 / 3 LEU A 245
TRP A 309
TYR A 240
 None
 1.02A 3aicA-1kkrA:
3.3		 3aicA-1kkrA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_F_ACRF5044_2
(GLUCOSYLTRANSFERASE-
SI)		 1kkr 3-METHYLASPARTATE
AMMONIA-LYASE
(Citrobacter
amalonaticus) 		3 / 3 LEU A 245
TRP A 309
TYR A 240
 None
 1.01A 3aicF-1kkrA:
3.8		 3aicF-1kkrA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AV6_A_SAMA1_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1)		 1kkr 3-METHYLASPARTATE
AMMONIA-LYASE
(Citrobacter
amalonaticus) 		5 / 12 GLY A 336
GLY A 133
LEU A 134
ALA A 129
VAL A 130
 None
 1.10A 3av6A-1kkrA:
undetectable		 3av6A-1kkrA:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB512_2
(PHOSPHOLIPASE A2)		 1kkr 3-METHYLASPARTATE
AMMONIA-LYASE
(Citrobacter
amalonaticus) 		4 / 7 VAL A 317
ILE A 330
GLY A 358
ARG A 382
 None
 0.70A 3bjwB-1kkrA:
undetectable		 3bjwB-1kkrA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB512_2
(PHOSPHOLIPASE A2)		 1kkr 3-METHYLASPARTATE
AMMONIA-LYASE
(Citrobacter
amalonaticus) 		4 / 7 VAL A 372
ILE A 338
GLN A 136
GLY A 337
 None
 0.85A 3bjwB-1kkrA:
undetectable		 3bjwB-1kkrA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_3
(PHOSPHOLIPASE A2)		 1kkr 3-METHYLASPARTATE
AMMONIA-LYASE
(Citrobacter
amalonaticus) 		4 / 7 VAL A 317
ILE A 330
GLY A 358
ARG A 382
 None
 0.84A 3bjwF-1kkrA:
undetectable		 3bjwF-1kkrA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH511_3
(PHOSPHOLIPASE A2)		 1kkr 3-METHYLASPARTATE
AMMONIA-LYASE
(Citrobacter
amalonaticus) 		4 / 7 VAL A 317
ILE A 330
GLY A 358
ARG A 382
 None
 0.78A 3bjwH-1kkrA:
undetectable		 3bjwH-1kkrA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYW_A_017A201_1
(HIV-1 PROTEASE)		 1kkr 3-METHYLASPARTATE
AMMONIA-LYASE
(Citrobacter
amalonaticus) 		5 / 12 LEU A 288
GLY A 323
ALA A 322
ILE A 316
ILE A 285
 None
 0.91A 3cywA-1kkrA:
undetectable		 3cywA-1kkrA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_D_BRLD478_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1kkr 3-METHYLASPARTATE
AMMONIA-LYASE
(Citrobacter
amalonaticus) 		5 / 12 SER A 300
HIS A 326
LEU A 270
VAL A 215
LEU A 211
 None
 1.17A 3dzyD-1kkrA:
0.0		 3dzyD-1kkrA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_B_478B200_1
(PROTEASE)		 1kkr 3-METHYLASPARTATE
AMMONIA-LYASE
(Citrobacter
amalonaticus) 		5 / 8 LEU A 288
GLY A 323
ALA A 322
ILE A 316
ILE A 285
 None
 1.11A 3ekpA-1kkrA:
undetectable		 3ekpA-1kkrA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LD6_A_KKKA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1kkr 3-METHYLASPARTATE
AMMONIA-LYASE
(Citrobacter
amalonaticus) 		5 / 12 PHE A 170
GLY A 174
ALA A 195
ILE A 272
ILE A 304
 None
 1.41A 3ld6A-1kkrA:
0.0		 3ld6A-1kkrA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_C_08JC3_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 1kkr 3-METHYLASPARTATE
AMMONIA-LYASE
(Citrobacter
amalonaticus) 		4 / 8 VAL A 239
LEU A 211
LEU A 204
ILE A 258
 None
 0.92A 3u5kC-1kkrA:
undetectable		 3u5kC-1kkrA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_A_TYLA1188_1
(BROMODOMAIN
CONTAINING 2)		 1kkr 3-METHYLASPARTATE
AMMONIA-LYASE
(Citrobacter
amalonaticus) 		4 / 5 VAL A 239
LEU A 211
LEU A 204
ILE A 258
 None
 0.95A 4a9jA-1kkrA:
undetectable		 4a9jA-1kkrA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1475_0
(MJ0495-LIKE PROTEIN)		 1kkr 3-METHYLASPARTATE
AMMONIA-LYASE
(Citrobacter
amalonaticus) 		4 / 8 ILE A 237
ASP A 238
ILE A 197
GLY A 205
 None
MG  A 501 ( 2.6A)
None
None
 0.81A 4ac9C-1kkrA:
undetectable		 4ac9C-1kkrA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_0
(WBDD)		 1kkr 3-METHYLASPARTATE
AMMONIA-LYASE
(Citrobacter
amalonaticus) 		6 / 12 GLY A 274
ILE A 304
GLN A 329
ILE A 272
HIS A 194
ILE A 237
 None
None
2AS  A 801 (-3.5A)
None
2AS  A 801 (-3.8A)
None
 1.22A 4ax8A-1kkrA:
undetectable		 4ax8A-1kkrA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_0
(WBDD)		 1kkr 3-METHYLASPARTATE
AMMONIA-LYASE
(Citrobacter
amalonaticus) 		6 / 12 GLY A 274
ILE A 304
GLN A 329
ILE A 272
VAL A 239
ILE A 237
 None
None
2AS  A 801 (-3.5A)
None
None
None
 1.19A 4ax8A-1kkrA:
undetectable		 4ax8A-1kkrA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HLA_A_017A200_1
(PROTEASE)		 1kkr 3-METHYLASPARTATE
AMMONIA-LYASE
(Citrobacter
amalonaticus) 		5 / 12 LEU A 288
GLY A 323
ALA A 322
ILE A 316
ILE A 285
 None
 0.89A 4hlaA-1kkrA:
undetectable		 4hlaA-1kkrA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LZR_A_LOCA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 1kkr 3-METHYLASPARTATE
AMMONIA-LYASE
(Citrobacter
amalonaticus) 		4 / 8 VAL A 239
LEU A 211
LEU A 204
ILE A 258
 None
 0.89A 4lzrA-1kkrA:
undetectable		 4lzrA-1kkrA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1kkr 3-METHYLASPARTATE
AMMONIA-LYASE
(Citrobacter
amalonaticus) 		4 / 8 ARG A 369
VAL A 106
VAL A  66
GLY A  67
 None
 1.01A 4mk4A-1kkrA:
undetectable		 4mk4A-1kkrA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_B_FK5B203_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 1kkr 3-METHYLASPARTATE
AMMONIA-LYASE
(Citrobacter
amalonaticus) 		3 / 3 ALA A 377
GLN A 136
GLY A 133
 None
 0.59A 4odoC-1kkrA:
undetectable		 4odoC-1kkrA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_1
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		 1kkr 3-METHYLASPARTATE
AMMONIA-LYASE
(Citrobacter
amalonaticus) 		5 / 12 THR A 142
VAL A 106
THR A 370
VAL A 374
GLN A 136
 None
 1.41A 4s0vA-1kkrA:
undetectable		 4s0vA-1kkrA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_1
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 1kkr 3-METHYLASPARTATE
AMMONIA-LYASE
(Citrobacter
amalonaticus) 		3 / 3 ARG A 131
ASN A 340
ASP A 315
 None
 0.66A 5gwxA-1kkrA:
undetectable		 5gwxA-1kkrA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IM2_A_BEZA401_0
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL)		 1kkr 3-METHYLASPARTATE
AMMONIA-LYASE
(Citrobacter
amalonaticus) 		5 / 12 PHE A  92
ILE A 121
LEU A  93
LEU A 134
VAL A 130
 None
 1.14A 5im2A-1kkrA:
0.0		 5im2A-1kkrA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0I_B_ACTB303_0
(SWI5-DEPENDENT HO
EXPRESSION PROTEIN 2)		 1kkr 3-METHYLASPARTATE
AMMONIA-LYASE
(Citrobacter
amalonaticus) 		4 / 5 VAL A 153
THR A 142
ASP A 140
LEU A 139
 None
 1.08A 5m0iB-1kkrA:
0.0		 5m0iB-1kkrA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWV_A_ACAA18_1
(SCRFP-TAG,GP41)		 1kkr 3-METHYLASPARTATE
AMMONIA-LYASE
(Citrobacter
amalonaticus) 		5 / 12 GLY A 301
LYS A 303
GLU A 264
GLU A 262
LEU A 261
 None
 1.31A 5nwvA-1kkrA:
0.0		 5nwvA-1kkrA:
8.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_2
(CYTOCHROME P450 2C9)		 1kkr 3-METHYLASPARTATE
AMMONIA-LYASE
(Citrobacter
amalonaticus) 		3 / 3 LEU A 160
VAL A 342
ASP A 343
 None
 0.66A 5x23A-1kkrA:
undetectable		 5x23A-1kkrA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_B_ECLB1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 1kkr 3-METHYLASPARTATE
AMMONIA-LYASE
(Citrobacter
amalonaticus) 		5 / 7 ALA A 278
ILE A 304
PHE A 319
LEU A 288
ILE A 246
 None
 1.46A 6b5vA-1kkrA:
undetectable
6b5vB-1kkrA:
undetectable		 6b5vA-1kkrA:
10.73
6b5vB-1kkrA:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BC9_A_ETSA302_2
(CARBONIC ANHYDRASE 2)		 1kkr 3-METHYLASPARTATE
AMMONIA-LYASE
(Citrobacter
amalonaticus) 		4 / 5 HIS A 326
GLU A 262
LEU A 211
VAL A 215
 None
 1.11A 6bc9A-1kkrA:
undetectable		 6bc9A-1kkrA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 1kkr 3-METHYLASPARTATE
AMMONIA-LYASE
(Citrobacter
amalonaticus) 		4 / 6 LEU A 245
TYR A  74
ASP A 238
GLN A 172
 None
None
MG  A 501 ( 2.6A)
2AS  A 801 (-3.1A)
 1.20A 6djzC-1kkrA:
0.9		 6djzC-1kkrA:
20.91