SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1kl7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EA1_A_TPFA470_1
(CYTOCHROME P450
51-LIKE RV0764C)		 1kl7 THREONINE SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 8 TYR A 137
PHE A 138
ARG A  86
PHE A 130
 None
 1.07A 1ea1A-1kl7A:
2.2		 1ea1A-1kl7A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_B_T44B328_1
(TRANSTHYRETIN)		 1kl7 THREONINE SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 8 ALA A 424
LEU A 327
GLU A 409
ALA A 462
 None
 0.94A 1ie4B-1kl7A:
undetectable
1ie4D-1kl7A:
undetectable		 1ie4B-1kl7A:
12.10
1ie4D-1kl7A:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_C_CHDC3271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 1kl7 THREONINE SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 8 LEU A  83
PHE A 130
LEU A 134
PHE A 138
 None
 0.77A 1v54C-1kl7A:
undetectable
1v54J-1kl7A:
0.0		 1v54C-1kl7A:
21.24
1v54J-1kl7A:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 1kl7 THREONINE SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 7 THR A 449
VAL A 425
GLY A 426
ASP A 281
 PLP  A1400 (-3.2A)
None
None
None
 0.97A 2a1mA-1kl7A:
0.0		 2a1mA-1kl7A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1kl7 THREONINE SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 8 LEU A  83
PHE A 130
LEU A 134
PHE A 138
 None
 0.76A 2dyrC-1kl7A:
undetectable
2dyrJ-1kl7A:
undetectable		 2dyrC-1kl7A:
21.24
2dyrJ-1kl7A:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1kl7 THREONINE SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 7 LEU A  83
PHE A 130
LEU A 134
PHE A 138
 None
 0.83A 2eikC-1kl7A:
undetectable
2eikJ-1kl7A:
0.0		 2eikC-1kl7A:
21.24
2eikJ-1kl7A:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1kl7 THREONINE SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 8 LEU A  83
PHE A 130
LEU A 134
PHE A 138
 None
 0.81A 2eilC-1kl7A:
undetectable
2eilJ-1kl7A:
undetectable		 2eilC-1kl7A:
21.24
2eilJ-1kl7A:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1kl7 THREONINE SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 8 LEU A  83
PHE A 130
LEU A 134
PHE A 138
 None
 0.91A 2eilP-1kl7A:
undetectable
2eilW-1kl7A:
undetectable		 2eilP-1kl7A:
21.24
2eilW-1kl7A:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6K_A_ADNA699_1
(CHLORINASE)		 1kl7 THREONINE SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 7 PHE A  91
TYR A 170
PRO A 119
THR A 120
 None
 1.30A 2q6kA-1kl7A:
0.0		 2q6kA-1kl7A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		 1kl7 THREONINE SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 8 TYR A  88
SER A  89
THR A  90
PRO A 119
 None
 0.76A 2v0zO-1kl7A:
undetectable		 2v0zO-1kl7A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)		 1kl7 THREONINE SYNTHASE
(Saccharomyces
cerevisiae) 		3 / 3 SER A  57
THR A  97
PHE A 272
 None
 0.69A 2x91A-1kl7A:
2.1		 2x91A-1kl7A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_C_CHDC1265_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1kl7 THREONINE SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 5 ARG A 319
PHE A 311
PHE A 376
LEU A 370
 None
 1.32A 2y69C-1kl7A:
0.0
2y69J-1kl7A:
0.0		 2y69C-1kl7A:
21.24
2y69J-1kl7A:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_P_CHDP1265_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1kl7 THREONINE SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 5 ARG A 319
PHE A 311
PHE A 376
LEU A 370
 None
 1.32A 2y69P-1kl7A:
0.0
2y69W-1kl7A:
0.0		 2y69P-1kl7A:
21.24
2y69W-1kl7A:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1kl7 THREONINE SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 6 LEU A  83
PHE A 130
LEU A 134
PHE A 138
 None
 0.86A 3abkP-1kl7A:
undetectable
3abkW-1kl7A:
0.0		 3abkP-1kl7A:
21.24
3abkW-1kl7A:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1kl7 THREONINE SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 5 ARG A 319
PHE A 311
PHE A 376
LEU A 370
 None
 1.34A 3abmC-1kl7A:
0.0
3abmJ-1kl7A:
0.0		 3abmC-1kl7A:
21.24
3abmJ-1kl7A:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1kl7 THREONINE SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 5 ARG A 319
PHE A 311
PHE A 376
LEU A 370
 None
 1.33A 3abmP-1kl7A:
0.0
3abmW-1kl7A:
0.0		 3abmP-1kl7A:
21.24
3abmW-1kl7A:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1kl7 THREONINE SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 7 ILE A 154
ILE A 242
LEU A 139
LEU A 128
 None
 0.80A 3adxA-1kl7A:
undetectable		 3adxA-1kl7A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1kl7 THREONINE SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 5 ARG A 319
PHE A 311
PHE A 376
LEU A 370
 None
 1.28A 3ag3C-1kl7A:
0.0
3ag3J-1kl7A:
0.0		 3ag3C-1kl7A:
21.24
3ag3J-1kl7A:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1kl7 THREONINE SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 8 LEU A  83
PHE A 130
LEU A 134
PHE A 138
 None
 0.74A 3ag4C-1kl7A:
undetectable
3ag4J-1kl7A:
0.0		 3ag4C-1kl7A:
21.24
3ag4J-1kl7A:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1kl7 THREONINE SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 7 LEU A  83
PHE A 130
LEU A 134
PHE A 138
 None
 0.75A 3ag4P-1kl7A:
undetectable
3ag4W-1kl7A:
0.0		 3ag4P-1kl7A:
21.24
3ag4W-1kl7A:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA606_1
(CHITINASE A)		 1kl7 THREONINE SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 7 GLY A 385
LYS A 388
TYR A 350
ARG A 348
 None
 0.94A 3arrA-1kl7A:
undetectable		 3arrA-1kl7A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA606_1
(CHITINASE A)		 1kl7 THREONINE SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 7 GLY A 385
LYS A 388
TYR A 350
ARG A 348
 None
 0.89A 3aruA-1kl7A:
undetectable		 3aruA-1kl7A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 1kl7 THREONINE SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 7 LEU A  83
PHE A 130
LEU A 134
PHE A 138
 None
 0.81A 3asnC-1kl7A:
undetectable
3asnJ-1kl7A:
0.0		 3asnC-1kl7A:
21.24
3asnJ-1kl7A:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_P_CHDP1271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 1kl7 THREONINE SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 7 LEU A  83
PHE A 130
LEU A 134
PHE A 138
 None
 0.84A 3asnP-1kl7A:
undetectable
3asnW-1kl7A:
undetectable		 3asnP-1kl7A:
21.24
3asnW-1kl7A:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 1kl7 THREONINE SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 8 LEU A  83
PHE A 130
LEU A 134
PHE A 138
 None
 0.77A 3asoC-1kl7A:
undetectable
3asoJ-1kl7A:
undetectable		 3asoC-1kl7A:
21.24
3asoJ-1kl7A:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_1
(HIV-1 PROTEASE)		 1kl7 THREONINE SYNTHASE
(Saccharomyces
cerevisiae) 		6 / 12 LEU A 172
GLY A 237
ALA A 238
ILE A 242
GLY A  28
ILE A  26
 None
 1.41A 3k4vA-1kl7A:
undetectable		 3k4vA-1kl7A:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_G_SAMG226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1kl7 THREONINE SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 12 ASP A 389
ASN A 338
GLY A 280
ALA A 288
ILE A 247
 None
None
PLP  A1400 (-3.8A)
None
None
 1.08A 3ku1G-1kl7A:
undetectable		 3ku1G-1kl7A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_C_ACHC323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 1kl7 THREONINE SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 8 PHE A 116
TYR A 121
GLU A 479
GLU A 478
 None
 1.10A 3rqwC-1kl7A:
undetectable
3rqwD-1kl7A:
undetectable		 3rqwC-1kl7A:
21.77
3rqwD-1kl7A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_J_ACHJ323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 1kl7 THREONINE SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 8 GLU A 479
GLU A 478
PHE A 116
TYR A 121
 None
 1.07A 3rqwF-1kl7A:
undetectable
3rqwJ-1kl7A:
undetectable		 3rqwF-1kl7A:
21.77
3rqwJ-1kl7A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_C_9PLC501_1
(CYTOCHROME P450 2E1)		 1kl7 THREONINE SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 5 PHE A  21
ALA A 249
THR A 252
LEU A  80
 None
 1.13A 3t3zC-1kl7A:
0.0		 3t3zC-1kl7A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_D_ADND301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 1kl7 THREONINE SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 10 GLY A 426
LEU A 110
LEU A 419
ASP A 420
ILE A 112
 None
 1.17A 3wdmD-1kl7A:
undetectable		 3wdmD-1kl7A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEL_A_ACRA1001_2
(ALPHA-GLUCOSIDASE)		 1kl7 THREONINE SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 6 ILE A  84
ILE A  41
MET A 251
TRP A  53
 None
 1.41A 3welA-1kl7A:
undetectable		 3welA-1kl7A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1kl7 THREONINE SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 6 LEU A  83
PHE A 130
LEU A 134
PHE A 138
 None
 0.74A 3wg7C-1kl7A:
undetectable
3wg7J-1kl7A:
0.0		 3wg7C-1kl7A:
21.24
3wg7J-1kl7A:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1kl7 THREONINE SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 7 LEU A  83
PHE A 130
LEU A 134
PHE A 138
 None
 0.78A 3x2qC-1kl7A:
undetectable
3x2qJ-1kl7A:
0.0		 3x2qC-1kl7A:
21.24
3x2qJ-1kl7A:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1kl7 THREONINE SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 7 LEU A  83
PHE A 130
LEU A 134
PHE A 138
 None
 0.97A 3x2qP-1kl7A:
undetectable
3x2qW-1kl7A:
0.0		 3x2qP-1kl7A:
21.24
3x2qW-1kl7A:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 1kl7 THREONINE SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 8 HIS A 422
PRO A 421
ASP A 420
ALA A 122
 PLP  A1400 (-3.8A)
None
None
PLP  A1400 ( 4.8A)
 1.06A 4k0bB-1kl7A:
undetectable		 4k0bB-1kl7A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K39_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 1kl7 THREONINE SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 339
ASN A 365
LEU A 351
VAL A 378
ILE A 382
 None
 1.38A 4k39A-1kl7A:
undetectable		 4k39A-1kl7A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_F_FOLF703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1kl7 THREONINE SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 273
PHE A 390
SER A 392
PHE A 339
VAL A 274
 None
 1.26A 4kyaF-1kl7A:
undetectable		 4kyaF-1kl7A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_A_0HKA2001_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 1kl7 THREONINE SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 12 ASP A 281
SER A 276
THR A 430
ALA A 429
TYR A 254
 None
PLP  A1400 (-4.5A)
None
None
None
 1.36A 4u15A-1kl7A:
undetectable		 4u15A-1kl7A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UAC_A_ACRA501_2
(CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT1 FAMILY
(TC 3.A.1.1.-))		 1kl7 THREONINE SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 7 GLU A 402
SER A 410
GLU A 431
ASP A 106
 None
 1.27A 4uacA-1kl7A:
0.0		 4uacA-1kl7A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_A_ACTA401_0
(PROTON-GATED ION
CHANNEL)		 1kl7 THREONINE SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 6 ILE A  25
PHE A 138
ILE A  70
GLU A  74
 None
 1.37A 4zzcA-1kl7A:
0.0
4zzcB-1kl7A:
0.0		 4zzcA-1kl7A:
20.64
4zzcB-1kl7A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_B_ACTB401_0
(PROTON-GATED ION
CHANNEL)		 1kl7 THREONINE SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 6 ILE A  25
PHE A 138
ILE A  70
GLU A  74
 None
 1.34A 4zzcB-1kl7A:
undetectable
4zzcC-1kl7A:
undetectable		 4zzcB-1kl7A:
20.64
4zzcC-1kl7A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1kl7 THREONINE SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 7 LEU A  83
PHE A 130
LEU A 134
PHE A 138
 None
 0.77A 5b1aC-1kl7A:
undetectable
5b1aJ-1kl7A:
undetectable		 5b1aC-1kl7A:
21.24
5b1aJ-1kl7A:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1kl7 THREONINE SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 7 LEU A  83
PHE A 130
LEU A 134
PHE A 138
 None
 0.79A 5b1aP-1kl7A:
undetectable
5b1aW-1kl7A:
undetectable		 5b1aP-1kl7A:
21.24
5b1aW-1kl7A:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1kl7 THREONINE SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 7 LEU A  83
PHE A 130
LEU A 134
PHE A 138
 None
 0.70A 5b1bP-1kl7A:
undetectable
5b1bW-1kl7A:
0.0		 5b1bP-1kl7A:
21.24
5b1bW-1kl7A:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBS_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 1kl7 THREONINE SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 8 LEU A  99
LEU A 447
THR A 430
TYR A 444
 None
 1.11A 5hbsA-1kl7A:
0.0		 5hbsA-1kl7A:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1kl7 THREONINE SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 7 LEU A  83
PHE A 130
LEU A 134
PHE A 138
 None
 0.80A 5iy5C-1kl7A:
undetectable
5iy5J-1kl7A:
0.0		 5iy5C-1kl7A:
20.87
5iy5J-1kl7A:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1kl7 THREONINE SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 118
HIS A 117
PHE A  58
GLN A  59
ALA A 127
 None
 1.16A 5n0xB-1kl7A:
1.6		 5n0xB-1kl7A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_2
(CYTOCHROME P450 3A4)		 1kl7 THREONINE SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 6 ARG A 319
PHE A 311
ILE A 300
THR A 302
 None
 0.99A 5vceA-1kl7A:
0.0		 5vceA-1kl7A:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1kl7 THREONINE SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 5 ARG A 319
PHE A 311
PHE A 376
LEU A 370
 None
 1.30A 5wauC-1kl7A:
0.0
5wauJ-1kl7A:
0.0		 5wauC-1kl7A:
21.24
5wauJ-1kl7A:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1kl7 THREONINE SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 5 ARG A 319
PHE A 311
PHE A 376
LEU A 370
 None
 1.28A 5wauc-1kl7A:
0.0
5wauj-1kl7A:
0.0		 5wauc-1kl7A:
21.24
5wauj-1kl7A:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1kl7 THREONINE SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 5 LEU A  83
PHE A 130
LEU A 134
PHE A 138
 None
 0.86A 5x19C-1kl7A:
undetectable
5x19J-1kl7A:
0.0		 5x19C-1kl7A:
21.24
5x19J-1kl7A:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 1kl7 THREONINE SYNTHASE
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 319
PHE A 311
LEU A 370
 None
 0.89A 5x1bC-1kl7A:
undetectable		 5x1bC-1kl7A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_P_CHDP304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1kl7 THREONINE SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 7 LEU A  83
PHE A 130
LEU A 134
PHE A 138
 None
 0.73A 5x1fP-1kl7A:
undetectable
5x1fW-1kl7A:
0.0		 5x1fP-1kl7A:
21.24
5x1fW-1kl7A:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1kl7 THREONINE SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 5 ARG A 319
PHE A 311
PHE A 376
LEU A 370
 None
 1.27A 5xdqC-1kl7A:
0.0
5xdqJ-1kl7A:
0.0		 5xdqC-1kl7A:
21.24
5xdqJ-1kl7A:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1kl7 THREONINE SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 5 ARG A 319
PHE A 311
PHE A 376
LEU A 370
 None
 1.28A 5xdqP-1kl7A:
0.0
5xdqW-1kl7A:
0.0		 5xdqP-1kl7A:
21.24
5xdqW-1kl7A:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1kl7 THREONINE SYNTHASE
(Saccharomyces
cerevisiae) 		4 / 7 LEU A  83
PHE A 130
LEU A 134
PHE A 138
 None
 0.72A 5z84C-1kl7A:
0.0
5z84J-1kl7A:
0.0		 5z84C-1kl7A:
21.24
5z84J-1kl7A:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 1kl7 THREONINE SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 10 ALA A 127
LEU A 128
VAL A 131
PHE A 135
ALA A 238
 None
 1.05A 6h1lA-1kl7A:
0.0		 6h1lA-1kl7A:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 1kl7 THREONINE SYNTHASE
(Saccharomyces
cerevisiae) 		5 / 11 ALA A 127
LEU A 128
VAL A 131
PHE A 135
ALA A 238
 None
 1.00A 6h1lB-1kl7A:
0.0		 6h1lB-1kl7A:
23.69