SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1kl9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		 1kl9 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2
SUBUNIT 1
(Homo
sapiens) 		3 / 3 LEU A 175
LEU A 126
PHE A 152
 None
 0.70A 2pgrA-1kl9A:
undetectable		 2pgrA-1kl9A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_A_BRLA1_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 1kl9 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2
SUBUNIT 1
(Homo
sapiens) 		3 / 3 ILE A 179
ILE A 161
LEU A 118
 None
 0.53A 2prgA-1kl9A:
undetectable		 2prgA-1kl9A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLY_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1kl9 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2
SUBUNIT 1
(Homo
sapiens) 		4 / 8 PHE A 130
GLU A  37
SER A 104
VAL A 107
 None
 1.37A 3nlyA-1kl9A:
undetectable
3nlyB-1kl9A:
undetectable		 3nlyA-1kl9A:
17.33
3nlyB-1kl9A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQL_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1kl9 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2
SUBUNIT 1
(Homo
sapiens) 		4 / 8 PHE A 130
GLU A  37
SER A 104
VAL A 107
 None
 1.36A 3rqlA-1kl9A:
2.6
3rqlB-1kl9A:
undetectable		 3rqlA-1kl9A:
17.33
3rqlB-1kl9A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CAP_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1kl9 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2
SUBUNIT 1
(Homo
sapiens) 		4 / 8 PHE A 130
GLU A  37
SER A 104
VAL A 107
 None
 1.38A 4capA-1kl9A:
undetectable
4capB-1kl9A:
undetectable		 4capA-1kl9A:
17.33
4capB-1kl9A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 1kl9 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2
SUBUNIT 1
(Homo
sapiens) 		4 / 5 LEU A  47
SER A  48
ASP A  83
ASP A  76
 None
 1.26A 4qtuD-1kl9A:
undetectable		 4qtuD-1kl9A:
18.94