SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1klp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_1
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 1klp MEROMYCOLATE
EXTENSION ACYL
CARRIER PROTEIN
(Mycobacterium
tuberculosis) 		4 / 5 PRO A  29
ALA A  90
ASP A  38
ASP A 101
 None
 1.18A 2nyuB-1klpA:
undetectable		 2nyuB-1klpA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_PCFA1179_0
(WNT INHIBITORY
FACTOR 1)		 1klp MEROMYCOLATE
EXTENSION ACYL
CARRIER PROTEIN
(Mycobacterium
tuberculosis) 		5 / 12 ILE A  16
LEU A  37
ILE A  27
MET A  44
VAL A  57
 None
 1.01A 2ygnA-1klpA:
undetectable		 2ygnA-1klpA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_B_RBFB201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1klp MEROMYCOLATE
EXTENSION ACYL
CARRIER PROTEIN
(Mycobacterium
tuberculosis) 		4 / 8 THR A  51
LEU A  67
VAL A  34
LEU A  37
 None
 0.91A 4r38B-1klpA:
undetectable		 4r38B-1klpA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_2
(PROTEASE)		 1klp MEROMYCOLATE
EXTENSION ACYL
CARRIER PROTEIN
(Mycobacterium
tuberculosis) 		3 / 3 LEU A  67
ASP A  36
ILE A  27
 None
 0.62A 6dh0B-1klpA:
undetectable		 6dh0B-1klpA:
17.54