SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1klq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1klq MITOTIC SPINDLE
ASSEMBLY CHECKPOINT
PROTEIN MAD2A
(Homo
sapiens) 		3 / 3 LEU A 144
PRO A 145
LEU A 147
 None
 0.59A 2po5B-1klqA:
undetectable		 2po5B-1klqA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1klq MITOTIC SPINDLE
ASSEMBLY CHECKPOINT
PROTEIN MAD2A
(Homo
sapiens) 		3 / 3 LEU A 144
PRO A 145
LEU A 147
 None
 0.54A 2po7B-1klqA:
undetectable		 2po7B-1klqA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1104_0
(FERROCHELATASE)		 1klq MITOTIC SPINDLE
ASSEMBLY CHECKPOINT
PROTEIN MAD2A
(Homo
sapiens) 		3 / 3 LEU A 144
PRO A 145
LEU A 147
 None
 0.49A 2qd5B-1klqA:
undetectable		 2qd5B-1klqA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA4_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1klq MITOTIC SPINDLE
ASSEMBLY CHECKPOINT
PROTEIN MAD2A
(Homo
sapiens) 		3 / 3 LEU A 144
PRO A 145
LEU A 147
 None
 0.24A 3hcrA-1klqA:
undetectable		 3hcrA-1klqA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OCT_A_1N1A663_2
(TYROSINE-PROTEIN
KINASE BTK)		 1klq MITOTIC SPINDLE
ASSEMBLY CHECKPOINT
PROTEIN MAD2A
(Homo
sapiens) 		4 / 5 PHE A  26
ILE A  21
ASN A  69
PHE A  25
 None
 0.99A 3octA-1klqA:
0.0		 3octA-1klqA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F93_B_SANB3004_1
(U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE)		 1klq MITOTIC SPINDLE
ASSEMBLY CHECKPOINT
PROTEIN MAD2A
(Homo
sapiens) 		4 / 8 GLU A 170
GLN A 175
GLY A 173
SER A 172
 None
 0.96A 4f93B-1klqA:
undetectable		 4f93B-1klqA:
7.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 1klq MITOTIC SPINDLE
ASSEMBLY CHECKPOINT
PROTEIN MAD2A
(Homo
sapiens) 		5 / 12 GLY A  38
VAL A  70
SER A  32
PHE A  45
ILE A  30
 None
 1.14A 5vooA-1klqA:
undetectable		 5vooA-1klqA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 1klq MITOTIC SPINDLE
ASSEMBLY CHECKPOINT
PROTEIN MAD2A
(Homo
sapiens) 		5 / 12 GLY A  38
VAL A  70
SER A  32
PHE A  45
ILE A  30
 None
 1.15A 5vooC-1klqA:
undetectable		 5vooC-1klqA:
20.27