SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1kmq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_B_DVAB6_0
(GRAMICIDIN A)		 1kmq TRANSFORMING PROTEIN
RHOA
(Homo
sapiens) 		4 / 4 VAL A  79
TRP A  58
ALA A  56
VAL A   9
 None
 1.41A 1gmkA-1kmqA:
undetectable
1gmkB-1kmqA:
undetectable		 1gmkA-1kmqA:
6.36
1gmkB-1kmqA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNO_A_DVAA6_0
(GRAMICIDIN A)		 1kmq TRANSFORMING PROTEIN
RHOA
(Homo
sapiens) 		3 / 3 ALA A  61
VAL A  11
TRP A  99
 None
 0.92A 1jnoA-1kmqA:
undetectable		 1jnoA-1kmqA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNO_B_DVAB6_0
(GRAMICIDIN A)		 1kmq TRANSFORMING PROTEIN
RHOA
(Homo
sapiens) 		3 / 3 ALA A  61
VAL A  11
TRP A  99
 None
 0.92A 1jnoB-1kmqA:
undetectable		 1jnoB-1kmqA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAG_A_DVAA6_0
(GRAMICIDIN A)		 1kmq TRANSFORMING PROTEIN
RHOA
(Homo
sapiens) 		3 / 3 ALA A  61
VAL A  11
TRP A  99
 None
 0.93A 1magA-1kmqA:
undetectable		 1magA-1kmqA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAG_B_DVAB6_0
(GRAMICIDIN A)		 1kmq TRANSFORMING PROTEIN
RHOA
(Homo
sapiens) 		3 / 3 ALA A  61
VAL A  11
TRP A  99
 None
 0.93A 1magB-1kmqA:
undetectable		 1magB-1kmqA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_A_DVAA6_0
(GRAMICIDIN A)		 1kmq TRANSFORMING PROTEIN
RHOA
(Homo
sapiens) 		3 / 3 ALA A  61
VAL A  11
TRP A  99
 None
 0.92A 1ng8A-1kmqA:
undetectable		 1ng8A-1kmqA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_B_DVAB6_0
(GRAMICIDIN A)		 1kmq TRANSFORMING PROTEIN
RHOA
(Homo
sapiens) 		3 / 3 ALA A  61
VAL A  11
TRP A  99
 None
 0.92A 1ng8B-1kmqA:
undetectable		 1ng8B-1kmqA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 1kmq TRANSFORMING PROTEIN
RHOA
(Homo
sapiens) 		4 / 6 ASP A  87
ASP A  13
ASN A  94
GLU A 137
 None
None
MG  A 402 (-2.7A)
None
 1.33A 1rjdB-1kmqA:
undetectable		 1rjdB-1kmqA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 1kmq TRANSFORMING PROTEIN
RHOA
(Homo
sapiens) 		4 / 6 ASP A  87
ASP A  13
ASN A  94
GLU A 137
 None
None
MG  A 402 (-2.7A)
None
 1.33A 1rjdC-1kmqA:
undetectable		 1rjdC-1kmqA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		 1kmq TRANSFORMING PROTEIN
RHOA
(Homo
sapiens) 		4 / 8 LEU A  81
ALA A  56
LEU A  55
TYR A  74
 None
 0.91A 3cldB-1kmqA:
0.0		 3cldB-1kmqA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O14_A_NIOA300_1
(ANTI-ECFSIGMA
FACTOR, CHRR)		 1kmq TRANSFORMING PROTEIN
RHOA
(Homo
sapiens) 		4 / 7 ALA A  44
VAL A  48
VAL A  53
LEU A  55
 None
 0.88A 3o14A-1kmqA:
0.0		 3o14A-1kmqA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_A_GAIA407_0
(PROTEIN (ARGINASE))		 1kmq TRANSFORMING PROTEIN
RHOA
(Homo
sapiens) 		4 / 6 ARG A 150
LEU A 114
MET A 147
ASP A 146
 None
 1.45A 4cevA-1kmqA:
undetectable
4cevB-1kmqA:
undetectable		 4cevA-1kmqA:
23.10
4cevB-1kmqA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_D_GAID410_0
(PROTEIN (ARGINASE))		 1kmq TRANSFORMING PROTEIN
RHOA
(Homo
sapiens) 		4 / 6 ARG A 150
LEU A 114
MET A 147
ASP A 146
 None
 1.42A 4cevD-1kmqA:
undetectable
4cevE-1kmqA:
undetectable		 4cevD-1kmqA:
23.10
4cevE-1kmqA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_F_GAIF411_0
(PROTEIN (ARGINASE))		 1kmq TRANSFORMING PROTEIN
RHOA
(Homo
sapiens) 		4 / 6 ARG A 150
LEU A 114
MET A 147
ASP A 146
 None
 1.43A 4cevE-1kmqA:
0.3
4cevF-1kmqA:
0.4		 4cevE-1kmqA:
23.10
4cevF-1kmqA:
23.10