SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1kn5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1EKJ_C_ACTC3004_0 (BETA-CARBONIC ANHYDRASE)	1kn5	TRANSCRIPTION REGULATORY PROTEIN ADR6 (Saccharomyces cerevisiae)	4 / 6	TYR A 79 ASP A 52 VAL A 54 GLY A 50	None	1.14A	1ekjC-1kn5A: undetectable 1ekjD-1kn5A: undetectable	1ekjC-1kn5A: 17.27 1ekjD-1kn5A: 17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1EKJ_C_ACTC3007_0 (BETA-CARBONIC ANHYDRASE)	1kn5	TRANSCRIPTION REGULATORY PROTEIN ADR6 (Saccharomyces cerevisiae)	4 / 6	ASP A 52 VAL A 54 GLY A 50 TYR A 79	None	1.14A	1ekjC-1kn5A: undetectable 1ekjD-1kn5A: undetectable	1ekjC-1kn5A: 17.27 1ekjD-1kn5A: 17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5UHB_C_RFPC1201_2 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA)	1kn5	TRANSCRIPTION REGULATORY PROTEIN ADR6 (Saccharomyces cerevisiae)	3 / 3	PHE A 48 ASP A 52 LEU A 38	None	0.77A	5uhbC-1kn5A: undetectable	5uhbC-1kn5A: 6.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5UHC_C_RFPC1201_2 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA)	1kn5	TRANSCRIPTION REGULATORY PROTEIN ADR6 (Saccharomyces cerevisiae)	3 / 3	PHE A 48 ASP A 52 LEU A 38	None	0.77A	5uhcC-1kn5A: undetectable	5uhcC-1kn5A: 6.40

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1EKJ_C_ACTC3004_0","BETA-CARBONIC ANHYDRASE","1kn5","TRANSCRIPTION REGULATORY PROTEIN ADR6","Saccharomyces cerevisiae",4,"TYR A  79;ASP A  52;VAL A  54;GLY A  50","None","1.14A","1ekjC-1kn5A:undetectable;1ekjD-1kn5A:undetectable","1ekjC-1kn5A:17.27;1ekjD-1kn5A:17.27"],["1EKJ_C_ACTC3007_0","BETA-CARBONIC ANHYDRASE","1kn5","TRANSCRIPTION REGULATORY PROTEIN ADR6","Saccharomyces cerevisiae",4,"ASP A  52;VAL A  54;GLY A  50;TYR A  79","None","1.14A","1ekjC-1kn5A:undetectable;1ekjD-1kn5A:undetectable","1ekjC-1kn5A:17.27;1ekjD-1kn5A:17.27"],["5UHB_C_RFPC1201_2","DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA","1kn5","TRANSCRIPTION REGULATORY PROTEIN ADR6","Saccharomyces cerevisiae",3,"PHE A  48;ASP A  52;LEU A  38","None","0.77A","5uhbC-1kn5A:undetectable","5uhbC-1kn5A:6.40"],["5UHC_C_RFPC1201_2","DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA","1kn5","TRANSCRIPTION REGULATORY PROTEIN ADR6","Saccharomyces cerevisiae",3,"PHE A  48;ASP A  52;LEU A  38","None","0.77A","5uhcC-1kn5A:undetectable","5uhcC-1kn5A:6.40"]]