SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1knx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1knx PROBABLE HPR(SER)
KINASE/PHOSPHATASE
(Mycoplasma
pneumoniae) 		4 / 5 LEU A 111
GLY A  34
PRO A  85
ALA A  86
 None
 0.89A 2aohA-1knxA:
undetectable		 2aohA-1knxA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		 1knx PROBABLE HPR(SER)
KINASE/PHOSPHATASE
(Mycoplasma
pneumoniae) 		4 / 7 PHE A  93
SER A  52
ILE A  50
GLY A  57
 None
 0.89A 2v0mB-1knxA:
undetectable		 2v0mB-1knxA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6V_E_RBFE201_1
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT B
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT E)		 1knx PROBABLE HPR(SER)
KINASE/PHOSPHATASE
(Mycoplasma
pneumoniae) 		4 / 5 VAL A 150
GLU A 144
VAL A 175
LYS A 221
 None
 1.22A 4p6vB-1knxA:
0.0
4p6vE-1knxA:
undetectable		 4p6vB-1knxA:
22.02
4p6vE-1knxA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_0
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 1knx PROBABLE HPR(SER)
KINASE/PHOSPHATASE
(Mycoplasma
pneumoniae) 		5 / 12 ILE A  30
GLY A  34
ILE A 110
PRO A  84
LEU A  80
 None
 1.06A 5e72A-1knxA:
undetectable		 5e72A-1knxA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 1knx PROBABLE HPR(SER)
KINASE/PHOSPHATASE
(Mycoplasma
pneumoniae) 		5 / 9 GLY A 140
ALA A 164
VAL A 141
GLU A 162
ILE A 180
 None
 1.42A 5i3cA-1knxA:
undetectable		 5i3cA-1knxA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUM_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 1knx PROBABLE HPR(SER)
KINASE/PHOSPHATASE
(Mycoplasma
pneumoniae) 		5 / 8 VAL A 258
ILE A 226
LEU A 189
ILE A 182
ILE A 138
 None
 1.30A 5numA-1knxA:
undetectable		 5numA-1knxA:
13.74