SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ko0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D8C_A_SORA4000_0
(MALATE SYNTHASE G)		 1ko0 DIAMINOPIMELATE
DECARBOXYLASE
(Escherichia
coli) 		3 / 3 GLN A 116
HIS A 137
PRO A 118
 None
 0.83A 1d8cA-1ko0A:
4.8		 1d8cA-1ko0A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3002_1
(SERUM ALBUMIN)		 1ko0 DIAMINOPIMELATE
DECARBOXYLASE
(Escherichia
coli) 		4 / 8 GLN A  45
LEU A 201
TYR A 198
LEU A 228
 None
 1.13A 1hk3A-1ko0A:
undetectable		 1hk3A-1ko0A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_B_DMEB996_1
(ACETYLCHOLINESTERASE)		 1ko0 DIAMINOPIMELATE
DECARBOXYLASE
(Escherichia
coli) 		4 / 6 GLU A  79
ILE A  36
TYR A  31
GLY A 278
 None
 1.17A 1maaB-1ko0A:
undetectable
1maaD-1ko0A:
undetectable		 1maaB-1ko0A:
22.63
1maaD-1ko0A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_C_THAC3_1
(LIVER
CARBOXYLESTERASE I)		 1ko0 DIAMINOPIMELATE
DECARBOXYLASE
(Escherichia
coli) 		5 / 12 LEU A 341
GLY A 301
THR A 375
LEU A 280
LEU A 392
 None
 1.25A 1mx1C-1ko0A:
undetectable		 1mx1C-1ko0A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PJ7_A_FFOA2887_1
(N,N-DIMETHYLGLYCINE
OXIDASE)		 1ko0 DIAMINOPIMELATE
DECARBOXYLASE
(Escherichia
coli) 		3 / 3 ASP A 102
THR A 100
GLU A 268
 None
PLP  A 540 ( 4.5A)
PLP  A 540 (-3.5A)
 0.66A 1pj7A-1ko0A:
undetectable		 1pj7A-1ko0A:
20.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TUF_B_AZ1B503_1
(DIAMINOPIMELATE
DECARBOXYLASE)		 1ko0 DIAMINOPIMELATE
DECARBOXYLASE
(Escherichia
coli) 		4 / 6 ARG A 271
ARG A 307
TYR A 311
TYR A 378
 LYS  A 541 ( 3.3A)
LYS  A 541 (-4.0A)
LYS  A 541 ( 4.4A)
LYS  A 541 (-3.4A)
 0.88A 1tufA-1ko0A:
42.0
1tufB-1ko0A:
42.4		 1tufA-1ko0A:
32.05
1tufB-1ko0A:
32.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_A_CLMA1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1ko0 DIAMINOPIMELATE
DECARBOXYLASE
(Escherichia
coli) 		4 / 7 GLY A 270
PRO A 269
ILE A 267
GLY A 226
 PLP  A 540 (-3.3A)
None
None
PLP  A 540 (-3.6A)
 0.80A 1usqA-1ko0A:
undetectable		 1usqA-1ko0A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_B_CLMB1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1ko0 DIAMINOPIMELATE
DECARBOXYLASE
(Escherichia
coli) 		4 / 6 GLY A 270
PRO A 269
ILE A 267
GLY A 226
 PLP  A 540 (-3.3A)
None
None
PLP  A 540 (-3.6A)
 0.82A 1usqB-1ko0A:
undetectable		 1usqB-1ko0A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_C_CLMC1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1ko0 DIAMINOPIMELATE
DECARBOXYLASE
(Escherichia
coli) 		4 / 6 GLY A 270
PRO A 269
ILE A 267
GLY A 226
 PLP  A 540 (-3.3A)
None
None
PLP  A 540 (-3.6A)
 0.82A 1usqC-1ko0A:
undetectable		 1usqC-1ko0A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_D_CLMD1142_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1ko0 DIAMINOPIMELATE
DECARBOXYLASE
(Escherichia
coli) 		4 / 6 GLY A 270
PRO A 269
ILE A 267
GLY A 226
 PLP  A 540 (-3.3A)
None
None
PLP  A 540 (-3.6A)
 0.80A 1usqD-1ko0A:
undetectable		 1usqD-1ko0A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_E_CLME1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1ko0 DIAMINOPIMELATE
DECARBOXYLASE
(Escherichia
coli) 		4 / 6 GLY A 270
PRO A 269
ILE A 267
GLY A 226
 PLP  A 540 (-3.3A)
None
None
PLP  A 540 (-3.6A)
 0.82A 1usqE-1ko0A:
undetectable		 1usqE-1ko0A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_F_CLMF1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1ko0 DIAMINOPIMELATE
DECARBOXYLASE
(Escherichia
coli) 		4 / 7 GLY A 270
PRO A 269
ILE A 267
GLY A 226
 PLP  A 540 (-3.3A)
None
None
PLP  A 540 (-3.6A)
 0.81A 1usqF-1ko0A:
undetectable		 1usqF-1ko0A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_C_CHDC3271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 1ko0 DIAMINOPIMELATE
DECARBOXYLASE
(Escherichia
coli) 		4 / 7 ARG A 111
LEU A 115
GLN A 116
LEU A  84
 None
 1.00A 1v55C-1ko0A:
undetectable
1v55J-1ko0A:
0.0		 1v55C-1ko0A:
16.36
1v55J-1ko0A:
8.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_P_CHDP4271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 1ko0 DIAMINOPIMELATE
DECARBOXYLASE
(Escherichia
coli) 		4 / 7 ARG A 111
LEU A 115
GLN A 116
LEU A  84
 None
 1.04A 1v55P-1ko0A:
undetectable
1v55W-1ko0A:
undetectable		 1v55P-1ko0A:
16.36
1v55W-1ko0A:
8.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_P_CHDP310_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1ko0 DIAMINOPIMELATE
DECARBOXYLASE
(Escherichia
coli) 		4 / 7 ARG A 111
LEU A 115
GLN A 116
LEU A  84
 None
 1.00A 2dysP-1ko0A:
undetectable
2dysW-1ko0A:
0.0		 2dysP-1ko0A:
16.36
2dysW-1ko0A:
8.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1ko0 DIAMINOPIMELATE
DECARBOXYLASE
(Escherichia
coli) 		4 / 7 ARG A 111
LEU A 115
GLN A 116
LEU A  84
 None
 1.04A 2eijC-1ko0A:
undetectable
2eijJ-1ko0A:
0.0		 2eijC-1ko0A:
16.36
2eijJ-1ko0A:
8.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1ko0 DIAMINOPIMELATE
DECARBOXYLASE
(Escherichia
coli) 		4 / 7 ARG A 111
LEU A 115
GLN A 116
LEU A  84
 None
 0.97A 2eimC-1ko0A:
undetectable
2eimJ-1ko0A:
undetectable		 2eimC-1ko0A:
16.36
2eimJ-1ko0A:
8.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1ko0 DIAMINOPIMELATE
DECARBOXYLASE
(Escherichia
coli) 		4 / 7 ARG A 111
LEU A 115
GLN A 116
LEU A  84
 None
 1.04A 2einC-1ko0A:
undetectable
2einJ-1ko0A:
undetectable		 2einC-1ko0A:
16.36
2einJ-1ko0A:
8.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1ko0 DIAMINOPIMELATE
DECARBOXYLASE
(Escherichia
coli) 		4 / 6 ARG A 111
LEU A 115
GLN A 116
LEU A  84
 None
 1.01A 2einP-1ko0A:
undetectable
2einW-1ko0A:
0.0		 2einP-1ko0A:
16.36
2einW-1ko0A:
8.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_A_STIA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 1ko0 DIAMINOPIMELATE
DECARBOXYLASE
(Escherichia
coli) 		4 / 6 LEU A 327
VAL A 347
VAL A 284
ILE A 317
 None
 0.98A 2hyyA-1ko0A:
undetectable		 2hyyA-1ko0A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_A_CLMA1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1ko0 DIAMINOPIMELATE
DECARBOXYLASE
(Escherichia
coli) 		4 / 6 GLY A 270
PRO A 269
ILE A 267
GLY A 226
 PLP  A 540 (-3.3A)
None
None
PLP  A 540 (-3.6A)
 0.84A 2jkjA-1ko0A:
undetectable		 2jkjA-1ko0A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_B_CLMB1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1ko0 DIAMINOPIMELATE
DECARBOXYLASE
(Escherichia
coli) 		4 / 6 GLY A 270
PRO A 269
ILE A 267
GLY A 226
 PLP  A 540 (-3.3A)
None
None
PLP  A 540 (-3.6A)
 0.84A 2jkjB-1ko0A:
undetectable		 2jkjB-1ko0A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_C_CLMC1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1ko0 DIAMINOPIMELATE
DECARBOXYLASE
(Escherichia
coli) 		4 / 6 GLY A 270
PRO A 269
ILE A 267
GLY A 226
 PLP  A 540 (-3.3A)
None
None
PLP  A 540 (-3.6A)
 0.84A 2jkjC-1ko0A:
undetectable		 2jkjC-1ko0A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_E_CLME1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1ko0 DIAMINOPIMELATE
DECARBOXYLASE
(Escherichia
coli) 		4 / 7 GLY A 270
PRO A 269
ILE A 267
GLY A 226
 PLP  A 540 (-3.3A)
None
None
PLP  A 540 (-3.6A)
 0.84A 2jkjE-1ko0A:
undetectable		 2jkjE-1ko0A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_A_CLMA1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1ko0 DIAMINOPIMELATE
DECARBOXYLASE
(Escherichia
coli) 		4 / 7 GLY A 270
PRO A 269
ILE A 267
GLY A 226
 PLP  A 540 (-3.3A)
None
None
PLP  A 540 (-3.6A)
 0.79A 2jklA-1ko0A:
undetectable		 2jklA-1ko0A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_B_CLMB1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1ko0 DIAMINOPIMELATE
DECARBOXYLASE
(Escherichia
coli) 		4 / 6 GLY A 270
PRO A 269
ILE A 267
GLY A 226
 PLP  A 540 (-3.3A)
None
None
PLP  A 540 (-3.6A)
 0.79A 2jklB-1ko0A:
undetectable		 2jklB-1ko0A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_C_CLMC1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1ko0 DIAMINOPIMELATE
DECARBOXYLASE
(Escherichia
coli) 		4 / 7 GLY A 270
PRO A 269
ILE A 267
GLY A 226
 PLP  A 540 (-3.3A)
None
None
PLP  A 540 (-3.6A)
 0.79A 2jklC-1ko0A:
undetectable		 2jklC-1ko0A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_D_CLMD1145_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1ko0 DIAMINOPIMELATE
DECARBOXYLASE
(Escherichia
coli) 		4 / 7 GLY A 270
PRO A 269
ILE A 267
GLY A 226
 PLP  A 540 (-3.3A)
None
None
PLP  A 540 (-3.6A)
 0.79A 2jklD-1ko0A:
undetectable		 2jklD-1ko0A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_E_CLME1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1ko0 DIAMINOPIMELATE
DECARBOXYLASE
(Escherichia
coli) 		4 / 7 GLY A 270
PRO A 269
ILE A 267
GLY A 226
 PLP  A 540 (-3.3A)
None
None
PLP  A 540 (-3.6A)
 0.79A 2jklE-1ko0A:
undetectable		 2jklE-1ko0A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_F_CLMF1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1ko0 DIAMINOPIMELATE
DECARBOXYLASE
(Escherichia
coli) 		4 / 7 GLY A 270
PRO A 269
ILE A 267
GLY A 226
 PLP  A 540 (-3.3A)
None
None
PLP  A 540 (-3.6A)
 0.79A 2jklF-1ko0A:
undetectable		 2jklF-1ko0A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_1
(ANDROGEN RECEPTOR)		 1ko0 DIAMINOPIMELATE
DECARBOXYLASE
(Escherichia
coli) 		5 / 12 GLY A 187
VAL A 119
ALA A 174
LEU A 175
PHE A 215
 None
 1.12A 2oz7A-1ko0A:
undetectable		 2oz7A-1ko0A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 1ko0 DIAMINOPIMELATE
DECARBOXYLASE
(Escherichia
coli) 		4 / 7 ARG A 111
LEU A 115
GLN A 116
LEU A  84
 None
 1.01A 3ag2C-1ko0A:
undetectable		 3ag2C-1ko0A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_A_SAMA465_0
(RRNA METHYLASE)		 1ko0 DIAMINOPIMELATE
DECARBOXYLASE
(Escherichia
coli) 		5 / 12 GLY A 226
GLY A 225
VAL A 274
ASP A  73
LEU A  62
 PLP  A 540 (-3.6A)
PLP  A 540 ( 4.8A)
None
PLP  A 540 ( 4.8A)
None
 1.11A 3m6vA-1ko0A:
undetectable		 3m6vA-1ko0A:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 1ko0 DIAMINOPIMELATE
DECARBOXYLASE
(Escherichia
coli) 		3 / 3 SER A 292
GLY A 291
GLN A 289
 None
 0.52A 3v4tH-1ko0A:
1.2		 3v4tH-1ko0A:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_1
(METHYLTRANSFERASE
WBDD)		 1ko0 DIAMINOPIMELATE
DECARBOXYLASE
(Escherichia
coli) 		3 / 3 GLN A 234
ASP A 374
GLN A 276
 None
 0.75A 4aztA-1ko0A:
0.0		 4aztA-1ko0A:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)		 1ko0 DIAMINOPIMELATE
DECARBOXYLASE
(Escherichia
coli) 		4 / 7 THR A 335
LEU A 327
VAL A 287
VAL A 296
 None
 1.00A 4cp4A-1ko0A:
undetectable		 4cp4A-1ko0A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MS4_A_2C0A501_1
(GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 1)		 1ko0 DIAMINOPIMELATE
DECARBOXYLASE
(Escherichia
coli) 		4 / 8 SER A 134
SER A 113
ILE A 104
GLU A 110
 None
 1.23A 4ms4A-1ko0A:
undetectable		 4ms4A-1ko0A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_2
(TUBULIN BETA-2B
CHAIN)		 1ko0 DIAMINOPIMELATE
DECARBOXYLASE
(Escherichia
coli) 		5 / 12 LEU A 175
LEU A 127
LEU A 185
ILE A 166
ILE A 188
 None
 1.11A 4o2bB-1ko0A:
undetectable		 4o2bB-1ko0A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAE_A_NIZA804_1
(CATALASE-PEROXIDASE)		 1ko0 DIAMINOPIMELATE
DECARBOXYLASE
(Escherichia
coli) 		4 / 6 ASP A 197
TYR A 198
LEU A 201
HIS A 149
 None
 1.17A 4paeA-1ko0A:
0.0		 4paeA-1ko0A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_A_MZMA303_1
(ALPHA-CARBONIC
ANHYDRASE)		 1ko0 DIAMINOPIMELATE
DECARBOXYLASE
(Escherichia
coli) 		5 / 12 ASP A  32
HIS A   3
HIS A 373
VAL A 279
LEU A  17
 None
 0.82A 4yhaA-1ko0A:
undetectable		 4yhaA-1ko0A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_A_MZMA303_1
(ALPHA-CARBONIC
ANHYDRASE)		 1ko0 DIAMINOPIMELATE
DECARBOXYLASE
(Escherichia
coli) 		5 / 12 HIS A   3
HIS A 373
VAL A 279
LEU A  17
ALA A  14
 None
 0.93A 4yhaA-1ko0A:
undetectable		 4yhaA-1ko0A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_A_MZMA303_1
(ALPHA-CARBONIC
ANHYDRASE)		 1ko0 DIAMINOPIMELATE
DECARBOXYLASE
(Escherichia
coli) 		5 / 12 HIS A   3
HIS A 373
VAL A 279
LEU A  17
ALA A  14
 None
 1.37A 4yhaA-1ko0A:
undetectable		 4yhaA-1ko0A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_B_MZMB303_1
(ALPHA-CARBONIC
ANHYDRASE)		 1ko0 DIAMINOPIMELATE
DECARBOXYLASE
(Escherichia
coli) 		5 / 10 ASP A  32
HIS A   3
HIS A 373
VAL A 279
ALA A  14
 None
 0.90A 4yhaB-1ko0A:
undetectable		 4yhaB-1ko0A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_C_MZMC303_1
(ALPHA-CARBONIC
ANHYDRASE)		 1ko0 DIAMINOPIMELATE
DECARBOXYLASE
(Escherichia
coli) 		5 / 11 ASP A  32
HIS A   3
HIS A 373
VAL A 279
LEU A  17
 None
 0.90A 4yhaC-1ko0A:
undetectable		 4yhaC-1ko0A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_E_MZME303_1
(ALPHA-CARBONIC
ANHYDRASE)		 1ko0 DIAMINOPIMELATE
DECARBOXYLASE
(Escherichia
coli) 		5 / 12 HIS A   3
HIS A 373
VAL A 279
LEU A  17
ALA A  14
 None
 1.01A 4yhaE-1ko0A:
undetectable		 4yhaE-1ko0A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ITZ_B_LOCB502_1
(TUBULIN BETA-2B
CHAIN)		 1ko0 DIAMINOPIMELATE
DECARBOXYLASE
(Escherichia
coli) 		5 / 12 LEU A 175
LEU A 127
LEU A 185
ILE A 166
ILE A 188
 None
 1.02A 5itzB-1ko0A:
1.2		 5itzB-1ko0A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIO_B_LOCB502_1
(TUBULIN BETA CHAIN)		 1ko0 DIAMINOPIMELATE
DECARBOXYLASE
(Escherichia
coli) 		5 / 12 LEU A 175
LEU A 127
LEU A 185
ILE A 166
ILE A 188
 None
 1.09A 5mioB-1ko0A:
undetectable		 5mioB-1ko0A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_A_HISA402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 1ko0 DIAMINOPIMELATE
DECARBOXYLASE
(Escherichia
coli) 		5 / 10 GLY A 226
LEU A 228
VAL A 274
ALA A 377
LEU A 273
 PLP  A 540 (-3.6A)
None
None
None
None
 1.12A 6czmA-1ko0A:
undetectable
6czmC-1ko0A:
undetectable		 6czmA-1ko0A:
24.27
6czmC-1ko0A:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_0
(ADENOSYLHOMOCYSTEINA
SE)		 1ko0 DIAMINOPIMELATE
DECARBOXYLASE
(Escherichia
coli) 		5 / 10 GLY A 376
GLY A 379
SER A 277
ASN A  58
ILE A  61
 None
 1.13A 6exiA-1ko0A:
undetectable		 6exiA-1ko0A:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_1
(ADENOSYLHOMOCYSTEINA
SE)		 1ko0 DIAMINOPIMELATE
DECARBOXYLASE
(Escherichia
coli) 		5 / 10 GLY A 376
GLY A 379
SER A 277
ASN A  58
ILE A  61
 None
 1.15A 6exiB-1ko0A:
undetectable		 6exiB-1ko0A:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC503_0
(ADENOSYLHOMOCYSTEINA
SE)		 1ko0 DIAMINOPIMELATE
DECARBOXYLASE
(Escherichia
coli) 		5 / 12 GLY A 376
GLY A 379
SER A 277
ASN A  58
ILE A  61
 None
 1.13A 6exiC-1ko0A:
undetectable
6exiD-1ko0A:
undetectable		 6exiC-1ko0A:
13.20
6exiD-1ko0A:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND503_0
(ADENOSYLHOMOCYSTEINA
SE)		 1ko0 DIAMINOPIMELATE
DECARBOXYLASE
(Escherichia
coli) 		5 / 12 GLY A 376
GLY A 379
SER A 277
ASN A  58
ILE A  61
 None
 1.15A 6exiC-1ko0A:
undetectable
6exiD-1ko0A:
undetectable		 6exiC-1ko0A:
13.20
6exiD-1ko0A:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_J_ZOLJ401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 1ko0 DIAMINOPIMELATE
DECARBOXYLASE
(Escherichia
coli) 		4 / 6 LEU A 396
ASP A 398
ARG A 403
GLN A  68
 None
 1.31A 6g31J-1ko0A:
undetectable		 6g31J-1ko0A:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_S_PCFS603_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 1ko0 DIAMINOPIMELATE
DECARBOXYLASE
(Escherichia
coli) 		4 / 7 GLN A 184
GLY A 136
HIS A 137
VAL A 133
 None
 0.99A 6hu9S-1ko0A:
0.0
6hu9q-1ko0A:
undetectable		 6hu9S-1ko0A:
10.90
6hu9q-1ko0A:
15.78