SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ko6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_B_HISB450_0
(HISTIDYL-TRNA
SYNTHETASE)		 1ko6 NUCLEAR PORE COMPLEX
PROTEIN NUP98
(Homo
sapiens) 		5 / 12 LEU A 826
TYR A 831
TYR A 849
GLY A 854
GLY A 808
 None
 1.28A 1httB-1ko6A:
undetectable		 1httB-1ko6A:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_C_HISC450_0
(HISTIDYL-TRNA
SYNTHETASE)		 1ko6 NUCLEAR PORE COMPLEX
PROTEIN NUP98
(Homo
sapiens) 		5 / 12 LEU A 826
TYR A 831
TYR A 849
GLY A 854
GLY A 808
 None
 1.31A 1httC-1ko6A:
undetectable		 1httC-1ko6A:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA156_1
(CALMODULIN)		 1ko6 NUCLEAR PORE COMPLEX
PROTEIN NUP98
(Homo
sapiens) 		5 / 8 ILE A 750
ILE A 777
GLU A 781
VAL A 782
ILE A 758
 None
 1.35A 1linA-1ko6A:
undetectable		 1linA-1ko6A:
25.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 1ko6 NUCLEAR PORE COMPLEX
PROTEIN NUP98
(Homo
sapiens) 		4 / 8 VAL A 775
THR A 749
TYR A 724
LEU A 719
 None
 1.04A 1z2bB-1ko6A:
undetectable		 1z2bB-1ko6A:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_I_TRPI1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1ko6 NUCLEAR PORE COMPLEX
PROTEIN NUP98
(Homo
sapiens) 		4 / 8 VAL A 764
ILE A 750
VAL A 775
VAL A 784
 None
 0.81A 3fi0I-1ko6A:
undetectable		 3fi0I-1ko6A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 1ko6 NUCLEAR PORE COMPLEX
PROTEIN NUP98
(Homo
sapiens) 		5 / 11 GLY A 756
GLY A 754
ASP A 807
THR A 853
GLU A 803
 None
 1.09A 3g88A-1ko6A:
0.9		 3g88A-1ko6A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 1ko6 NUCLEAR PORE COMPLEX
PROTEIN NUP98
(Homo
sapiens) 		5 / 11 GLY A 756
GLY A 754
ASP A 807
THR A 853
GLU A 803
 None
 1.09A 3g88B-1ko6A:
0.6		 3g88B-1ko6A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 1ko6 NUCLEAR PORE COMPLEX
PROTEIN NUP98
(Homo
sapiens) 		5 / 12 GLY A 756
GLY A 754
ASP A 807
THR A 853
GLU A 803
 None
 1.04A 3g89A-1ko6A:
1.0		 3g89A-1ko6A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 1ko6 NUCLEAR PORE COMPLEX
PROTEIN NUP98
(Homo
sapiens) 		5 / 11 GLY A 756
GLY A 754
ASP A 807
THR A 853
GLU A 803
 None
 1.03A 3g89B-1ko6A:
0.9		 3g89B-1ko6A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 1ko6 NUCLEAR PORE COMPLEX
PROTEIN NUP98
(Homo
sapiens) 		5 / 12 GLY A 756
GLY A 754
ASP A 807
THR A 853
GLU A 803
 None
 1.05A 3g8bA-1ko6A:
0.0		 3g8bA-1ko6A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 1ko6 NUCLEAR PORE COMPLEX
PROTEIN NUP98
(Homo
sapiens) 		5 / 12 GLY A 756
GLY A 754
ASP A 807
THR A 853
GLU A 803
 None
 1.06A 3g8bB-1ko6A:
0.0		 3g8bB-1ko6A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JQ1_A_NPSA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 1ko6 NUCLEAR PORE COMPLEX
PROTEIN NUP98
(Homo
sapiens) 		5 / 9 VAL A 784
TYR A 785
VAL A 782
ILE A 777
LEU A 766
 None
 1.31A 4jq1A-1ko6A:
0.0		 4jq1A-1ko6A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AOX_C_ACTC1001_0
(ALU JO CONSENSUS RNA
SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN)		 1ko6 NUCLEAR PORE COMPLEX
PROTEIN NUP98
(Homo
sapiens) 		3 / 3 TYR A 759
THR A 805
THR A 749
 None
 0.81A 5aoxB-1ko6A:
0.0		 5aoxB-1ko6A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FUK_A_SNPA1236_1
(MROUPO)		 1ko6 NUCLEAR PORE COMPLEX
PROTEIN NUP98
(Homo
sapiens) 		4 / 7 ILE A 774
THR A 726
ILE A 750
LEU A 769
 None
 0.79A 5fukA-1ko6A:
undetectable
5fukB-1ko6A:
undetectable		 5fukA-1ko6A:
20.75
5fukB-1ko6A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_0
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 1ko6 NUCLEAR PORE COMPLEX
PROTEIN NUP98
(Homo
sapiens) 		5 / 12 ASN A 765
VAL A 775
ILE A 744
THR A 749
ILE A 750
 None
 1.45A 6j20A-1ko6A:
undetectable		 6j20A-1ko6A:
17.69