SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ko7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA206_1
(CARDIAC TROPONIN C)		 1ko7 HPR
KINASE/PHOSPHATASE
(Staphylococcus
xylosus) 		4 / 8 PRO A  34
GLU A  37
GLU A  80
ASP A  48
 None
 0.90A 1dtlA-1ko7A:
undetectable		 1dtlA-1ko7A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZQ_A_PCFA954_0
(CATECHOL
1,2-DIOXYGENASE)		 1ko7 HPR
KINASE/PHOSPHATASE
(Staphylococcus
xylosus) 		5 / 9 THR A   4
LEU A  22
GLU A 104
HIS A 103
ALA A 100
 None
 1.36A 2azqA-1ko7A:
0.0		 2azqA-1ko7A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZQ_A_PCFA954_0
(CATECHOL
1,2-DIOXYGENASE)		 1ko7 HPR
KINASE/PHOSPHATASE
(Staphylococcus
xylosus) 		5 / 9 THR A   4
LEU A  22
GLU A 104
HIS A 103
GLU A  98
 None
 1.03A 2azqA-1ko7A:
0.0		 2azqA-1ko7A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q8H_A_TF4A438_1
([PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 1)		 1ko7 HPR
KINASE/PHOSPHATASE
(Staphylococcus
xylosus) 		4 / 6 LEU A 121
ILE A  85
ARG A  33
ILE A  31
 None
None
PO4  A 315 (-2.8A)
None
 0.98A 2q8hA-1ko7A:
undetectable		 2q8hA-1ko7A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3A_A_TOPA1190_1
(DIHYDROFOLATE
REDUCTASE)		 1ko7 HPR
KINASE/PHOSPHATASE
(Staphylococcus
xylosus) 		5 / 11 ILE A 201
ALA A 161
ILE A 195
PRO A 192
THR A 160
 None
 1.23A 2w3aA-1ko7A:
undetectable		 2w3aA-1ko7A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1ko7 HPR
KINASE/PHOSPHATASE
(Staphylococcus
xylosus) 		4 / 8 ILE A 273
ASN A 283
VAL A 145
GLY A 146
 None
 0.83A 3em0B-1ko7A:
undetectable		 3em0B-1ko7A:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_B_URFB2011_1
(URIDINE
PHOSPHORYLASE)		 1ko7 HPR
KINASE/PHOSPHATASE
(Staphylococcus
xylosus) 		5 / 10 THR A 254
GLU A 255
LEU A 187
LEU A 224
ILE A 179
 None
 1.34A 3kvrB-1ko7A:
undetectable		 3kvrB-1ko7A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_A_URFA400_1
(URIDINE
PHOSPHORYLASE 1)		 1ko7 HPR
KINASE/PHOSPHATASE
(Staphylococcus
xylosus) 		5 / 9 THR A 254
GLU A 255
LEU A 187
LEU A 224
ILE A 179
 None
 1.35A 3nbqA-1ko7A:
undetectable		 3nbqA-1ko7A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_A_CAMA423_0
(CYTOCHROME P450)		 1ko7 HPR
KINASE/PHOSPHATASE
(Staphylococcus
xylosus) 		5 / 12 ILE A 273
THR A 260
GLY A 151
VAL A 263
ILE A 261
 None
 0.93A 4c9oA-1ko7A:
undetectable		 4c9oA-1ko7A:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_B_CAMB423_0
(CYTOCHROME P450)		 1ko7 HPR
KINASE/PHOSPHATASE
(Staphylococcus
xylosus) 		5 / 12 ILE A 273
THR A 260
GLY A 151
VAL A 263
ILE A 261
 None
 0.92A 4c9oB-1ko7A:
undetectable		 4c9oB-1ko7A:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WW7_A_ACTA305_0
(EKC/KEOPS COMPLEX
SUBUNIT BUD32)		 1ko7 HPR
KINASE/PHOSPHATASE
(Staphylococcus
xylosus) 		4 / 6 LEU A 198
LEU A 199
GLU A 200
ILE A 207
 None
 0.86A 4ww7A-1ko7A:
undetectable		 4ww7A-1ko7A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT8_A_TMQA302_1
(RV2671)		 1ko7 HPR
KINASE/PHOSPHATASE
(Staphylococcus
xylosus) 		5 / 12 ASN A 208
ILE A 218
SER A 217
GLY A 216
ALA A 215
 None
 1.20A 4xt8A-1ko7A:
undetectable		 4xt8A-1ko7A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_B_ACTB401_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT
N6-ADENOSINE-METHYLT
RANSFERASE SUBUNIT
METTL14)		 1ko7 HPR
KINASE/PHOSPHATASE
(Staphylococcus
xylosus) 		4 / 6 ARG A  78
LEU A  76
ARG A  74
ARG A  72
 None
 1.26A 5l6eA-1ko7A:
undetectable
5l6eB-1ko7A:
undetectable		 5l6eA-1ko7A:
22.71
5l6eB-1ko7A:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 1ko7 HPR
KINASE/PHOSPHATASE
(Staphylococcus
xylosus) 		4 / 7 ILE A 179
LEU A 135
ARG A 225
LEU A 249
 None
 0.97A 5xdxA-1ko7A:
undetectable
5xdxJ-1ko7A:
0.0		 5xdxA-1ko7A:
20.61
5xdxJ-1ko7A:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 1ko7 HPR
KINASE/PHOSPHATASE
(Staphylococcus
xylosus) 		4 / 8 ILE A 261
THR A 260
THR A 257
GLU A 246
 None
 1.02A 6c06C-1ko7A:
undetectable		 6c06C-1ko7A:
undetectable