SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1koa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OSV_A_CHCA202_1
(BILE ACID RECEPTOR)		 1koa TWITCHIN
(Caenorhabditis
elegans) 		5 / 12 MET A6035
ARG A6213
SER A6134
PHE A6163
ILE A6174
 None
 1.50A 1osvA-1koaA:
0.0		 1osvA-1koaA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 1koa TWITCHIN
(Caenorhabditis
elegans) 		4 / 7 ALA A6291
PHE A6268
ARG A6339
ASN A6342
 None
 1.35A 1t9wA-1koaA:
0.0		 1t9wA-1koaA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_A_PNXA1435_1
(CHITINASE)		 1koa TWITCHIN
(Caenorhabditis
elegans) 		4 / 6 TYR A6214
GLY A6165
PHE A6163
SER A6164
 None
 1.36A 2a3cA-1koaA:
undetectable		 2a3cA-1koaA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA802_1
(PROSTAGLANDIN
REDUCTASE 1)		 1koa TWITCHIN
(Caenorhabditis
elegans) 		4 / 7 VAL A6351
TYR A6336
GLY A6322
ASP A6320
 None
 0.75A 2y05A-1koaA:
undetectable
2y05B-1koaA:
undetectable		 2y05A-1koaA:
19.44
2y05B-1koaA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_C_NILC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 1koa TWITCHIN
(Caenorhabditis
elegans) 		5 / 12 ALA A5969
GLU A5987
MET A5991
LEU A5999
PHE A6018
 None
 0.79A 3cs9C-1koaA:
16.5		 3cs9C-1koaA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_C_DX2C270_1
(PTERIDINE REDUCTASE
1)		 1koa TWITCHIN
(Caenorhabditis
elegans) 		4 / 8 PHE A6025
TYR A6214
VAL A6127
PRO A6066
 None
 1.15A 3jq7C-1koaA:
undetectable		 3jq7C-1koaA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1koa TWITCHIN
(Caenorhabditis
elegans) 		5 / 12 ALA A6088
GLY A6085
SER A6243
ASP A6063
LEU A6062
 None
 1.37A 3ou6D-1koaA:
undetectable		 3ou6D-1koaA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UE4_A_DB8A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 1koa TWITCHIN
(Caenorhabditis
elegans) 		7 / 12 LEU A5948
ALA A5969
LYS A5971
GLU A5987
VAL A6000
PHE A6018
MET A6019
 None
 1.04A 3ue4A-1koaA:
23.2		 3ue4A-1koaA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1002_1
(HEMOLYTIC LECTIN
CEL-III)		 1koa TWITCHIN
(Caenorhabditis
elegans) 		3 / 3 ASP A6302
GLU A6335
GLY A6334
 None
 0.61A 3w9tA-1koaA:
0.0		 3w9tA-1koaA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRH_D_RAPD201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)		 1koa TWITCHIN
(Caenorhabditis
elegans) 		5 / 12 TYR A5942
ASP A6004
HIS A5941
TYR A5926
PHE A5968
 None
 1.21A 4drhD-1koaA:
undetectable		 4drhD-1koaA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJL_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1koa TWITCHIN
(Caenorhabditis
elegans) 		4 / 4 MET A6054
ASP A6121
LEU A6064
ARG A6245
 None
 1.30A 4kjlA-1koaA:
0.0		 4kjlA-1koaA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTI_A_MI1A1001_1
(SERINE/THREONINE-PRO
TEIN KINASE N1)		 1koa TWITCHIN
(Caenorhabditis
elegans) 		7 / 12 LEU A5948
GLY A5949
GLY A5951
GLY A5954
VAL A5956
ALA A5969
LYS A5971
 None
 0.57A 4otiA-1koaA:
20.4		 4otiA-1koaA:
26.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_H_TR6H101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 1koa TWITCHIN
(Caenorhabditis
elegans) 		3 / 5 GLY A5951
GLY A5949
GLU A5947
 None
 0.48A 4z2eA-1koaA:
3.3
4z2eD-1koaA:
undetectable		 4z2eA-1koaA:
21.74
4z2eD-1koaA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 1koa TWITCHIN
(Caenorhabditis
elegans) 		5 / 8 LEU A5948
GLY A5949
VAL A5956
ALA A5969
MET A6019
 None
 0.89A 4zauA-1koaA:
22.9		 4zauA-1koaA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZY_A_SAMA603_0
(LEGIONELLA EFFECTOR
LEGAS4)		 1koa TWITCHIN
(Caenorhabditis
elegans) 		5 / 12 TYR A6016
ASN A6001
GLU A5961
TYR A5926
TYR A5927
 None
 1.37A 5czyA-1koaA:
0.0		 5czyA-1koaA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1koa TWITCHIN
(Caenorhabditis
elegans) 		5 / 8 ILE A5944
VAL A5959
ILE A5988
ILE A5933
ASP A6004
 None
 1.04A 5hi2A-1koaA:
22.3		 5hi2A-1koaA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)		 1koa TWITCHIN
(Caenorhabditis
elegans) 		5 / 7 GLY A5949
GLY A5951
PHE A5953
VAL A5956
LYS A5971
 None
 0.92A 5izjA-1koaA:
19.2		 5izjA-1koaA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_B_BEZB201_0
(NS3 PROTEASE)		 1koa TWITCHIN
(Caenorhabditis
elegans) 		4 / 5 HIS A6089
ALA A6264
SER A6292
TYR A6118
 None
 1.09A 5yodB-1koaA:
0.0		 5yodB-1koaA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_D_BEZD201_0
(NS3 PROTEASE)		 1koa TWITCHIN
(Caenorhabditis
elegans) 		4 / 5 HIS A6089
ALA A6264
SER A6292
TYR A6118
 None
 1.23A 5yodD-1koaA:
undetectable		 5yodD-1koaA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWV_A_BEZA202_0
(ARA H 8 ALLERGEN)		 1koa TWITCHIN
(Caenorhabditis
elegans) 		4 / 4 PHE A6173
ASP A6172
LEU A6177
LYS A6176
 None
 1.48A 6awvA-1koaA:
1.0		 6awvA-1koaA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9B_A_IXXA609_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN
ENVELOPE
GLYCOPROTEIN)		 1koa TWITCHIN
(Caenorhabditis
elegans) 		4 / 7 ILE A6174
LEU A6177
VAL A6047
LEU A6064
 None
 0.66A 6g9bA-1koaA:
undetectable
6g9bB-1koaA:
0.0		 6g9bA-1koaA:
10.15
6g9bB-1koaA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JNH_A_ASCA202_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 1koa TWITCHIN
(Caenorhabditis
elegans) 		3 / 3 ASN A6001
PRO A5928
GLN A5929
 None
 0.94A 6jnhA-1koaA:
0.0		 6jnhA-1koaA:
17.14