SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1kob'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 1kob TWITCHIN
(Aplysia
californica) 		4 / 6 ILE A 152
TRP A 307
PHE A 284
GLU A 280
 None
 1.38A 1nsiA-1kobA:
0.0
1nsiB-1kobA:
0.0		 1nsiA-1kobA:
20.70
1nsiB-1kobA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 1kob TWITCHIN
(Aplysia
californica) 		4 / 6 TRP A 307
PHE A 284
GLU A 280
ILE A 152
 None
 1.39A 1nsiA-1kobA:
0.0
1nsiB-1kobA:
0.0		 1nsiA-1kobA:
20.70
1nsiB-1kobA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_C_H4BC602_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 1kob TWITCHIN
(Aplysia
californica) 		4 / 6 ILE A 152
TRP A 307
PHE A 284
GLU A 280
 None
 1.44A 1nsiC-1kobA:
0.0
1nsiD-1kobA:
0.0		 1nsiC-1kobA:
20.70
1nsiD-1kobA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_D_H4BD603_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 1kob TWITCHIN
(Aplysia
californica) 		4 / 6 TRP A 307
PHE A 284
GLU A 280
ILE A 152
 None
 1.36A 1nsiC-1kobA:
0.0
1nsiD-1kobA:
0.0		 1nsiC-1kobA:
20.70
1nsiD-1kobA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVT_A_PRLA311_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 1kob TWITCHIN
(Aplysia
californica) 		4 / 8 GLU A 150
TYR A 154
ILE A 139
TYR A 324
 None
 0.99A 1qvtA-1kobA:
0.1		 1qvtA-1kobA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_E_NCAE507_0
(NAD-DEPENDENT
DEACETYLASE 2)		 1kob TWITCHIN
(Aplysia
californica) 		4 / 7 LEU A 105
ASN A 179
ILE A 175
ASP A 174
 None
 0.97A 1yc2E-1kobA:
undetectable		 1yc2E-1kobA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 1kob TWITCHIN
(Aplysia
californica) 		4 / 7 ILE A 152
TRP A 307
PHE A 284
GLU A 280
 None
 1.38A 2nsiA-1kobA:
undetectable
2nsiB-1kobA:
0.0		 2nsiA-1kobA:
20.70
2nsiB-1kobA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 1kob TWITCHIN
(Aplysia
californica) 		4 / 7 TRP A 307
PHE A 284
GLU A 280
ILE A 152
 None
 1.40A 2nsiA-1kobA:
undetectable
2nsiB-1kobA:
0.0		 2nsiA-1kobA:
20.70
2nsiB-1kobA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_C_H4BC602_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 1kob TWITCHIN
(Aplysia
californica) 		4 / 7 ILE A 152
TRP A 307
PHE A 284
GLU A 280
 None
 1.41A 2nsiC-1kobA:
undetectable
2nsiD-1kobA:
undetectable		 2nsiC-1kobA:
20.70
2nsiD-1kobA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_D_H4BD603_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 1kob TWITCHIN
(Aplysia
californica) 		4 / 7 TRP A 307
PHE A 284
GLU A 280
ILE A 152
 None
 1.39A 2nsiC-1kobA:
undetectable
2nsiD-1kobA:
0.0		 2nsiC-1kobA:
20.70
2nsiD-1kobA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1kob TWITCHIN
(Aplysia
californica) 		4 / 7 ASP A 232
LEU A 173
ILE A 170
GLU A 373
 None
 0.97A 2qqdA-1kobA:
0.0
2qqdE-1kobA:
0.0		 2qqdA-1kobA:
10.62
2qqdE-1kobA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_B_Y00B601_2
(BETA-1 ADRENERGIC
RECEPTOR)		 1kob TWITCHIN
(Aplysia
californica) 		3 / 3 VAL A  42
ASN A 112
TRP A  34
 None
 1.10A 2y00B-1kobA:
undetectable		 2y00B-1kobA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1kob TWITCHIN
(Aplysia
californica) 		4 / 7 ILE A 152
TRP A 307
PHE A 284
GLU A 280
 None
 1.37A 3e7gA-1kobA:
0.0
3e7gB-1kobA:
undetectable		 3e7gA-1kobA:
21.48
3e7gB-1kobA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_B_H4BB1902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1kob TWITCHIN
(Aplysia
californica) 		4 / 7 TRP A 307
PHE A 284
GLU A 280
ILE A 152
 None
 1.36A 3e7gA-1kobA:
0.0
3e7gB-1kobA:
0.0		 3e7gA-1kobA:
21.48
3e7gB-1kobA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_C_H4BC2902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1kob TWITCHIN
(Aplysia
californica) 		4 / 7 ILE A 152
TRP A 307
PHE A 284
GLU A 280
 None
 1.36A 3e7gC-1kobA:
0.0
3e7gD-1kobA:
0.0		 3e7gC-1kobA:
21.48
3e7gD-1kobA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_D_H4BD3902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1kob TWITCHIN
(Aplysia
californica) 		4 / 8 TRP A 307
PHE A 284
GLU A 280
ILE A 152
 None
 1.37A 3e7gC-1kobA:
undetectable
3e7gD-1kobA:
undetectable		 3e7gC-1kobA:
21.48
3e7gD-1kobA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1kob TWITCHIN
(Aplysia
californica) 		5 / 10 ILE A 111
ILE A 193
GLY A 133
PRO A 341
VAL A  67
 None
 1.29A 3elzB-1kobA:
0.0		 3elzB-1kobA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1kob TWITCHIN
(Aplysia
californica) 		5 / 12 PHE A 195
ASP A 232
ILE A 364
GLY A 196
ALA A 198
 None
 1.08A 3sudB-1kobA:
undetectable		 3sudB-1kobA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WAR_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA)		 1kob TWITCHIN
(Aplysia
californica) 		4 / 8 VAL A  67
VAL A  80
LYS A  82
ILE A 111
 None
 0.37A 3warA-1kobA:
23.9		 3warA-1kobA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1kob TWITCHIN
(Aplysia
californica) 		4 / 8 TRP A 307
PHE A 284
GLU A 280
ILE A 152
 None
 1.36A 4cx7A-1kobA:
undetectable
4cx7B-1kobA:
undetectable		 4cx7A-1kobA:
20.70
4cx7B-1kobA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_D_H4BD600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1kob TWITCHIN
(Aplysia
californica) 		4 / 7 TRP A 307
PHE A 284
GLU A 280
ILE A 152
 None
 1.43A 4cx7C-1kobA:
undetectable
4cx7D-1kobA:
undetectable		 4cx7C-1kobA:
20.70
4cx7D-1kobA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_B_H4BB1011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 1kob TWITCHIN
(Aplysia
californica) 		4 / 7 TRP A 307
PHE A 284
GLU A 280
ILE A 152
 None
 1.39A 4nosA-1kobA:
undetectable
4nosB-1kobA:
0.0		 4nosA-1kobA:
22.63
4nosB-1kobA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_C_H4BC2011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 1kob TWITCHIN
(Aplysia
californica) 		4 / 7 ILE A 152
TRP A 307
PHE A 284
GLU A 280
 None
 1.38A 4nosC-1kobA:
undetectable
4nosD-1kobA:
undetectable		 4nosC-1kobA:
22.63
4nosD-1kobA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_D_H4BD3011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 1kob TWITCHIN
(Aplysia
californica) 		4 / 6 TRP A 307
PHE A 284
GLU A 280
ILE A 152
 None
 1.41A 4nosC-1kobA:
0.0
4nosD-1kobA:
0.0		 4nosC-1kobA:
22.63
4nosD-1kobA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_2
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 1kob TWITCHIN
(Aplysia
californica) 		3 / 3 LEU A 105
LEU A 130
ASN A 179
 None
 0.60A 4otwA-1kobA:
20.8		 4otwA-1kobA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_C_RBFC201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1kob TWITCHIN
(Aplysia
californica) 		5 / 9 THR A  94
ILE A 101
VAL A 209
LEU A 197
ILE A 364
 None
 1.08A 4r38C-1kobA:
0.9		 4r38C-1kobA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_A_WJZA304_0
(BETA-LACTAMASE NDM-1)		 1kob TWITCHIN
(Aplysia
californica) 		4 / 8 VAL A 299
HIS A 172
ASP A 232
HIS A 166
 None
 0.87A 5a5zA-1kobA:
undetectable		 5a5zA-1kobA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_1
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 1kob TWITCHIN
(Aplysia
californica) 		3 / 3 ARG A 355
ASN A 179
ASP A 232
 None
 0.84A 5gwxA-1kobA:
undetectable		 5gwxA-1kobA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)		 1kob TWITCHIN
(Aplysia
californica) 		4 / 7 GLY A  60
GLY A  62
GLY A  65
VAL A  67
 None
 0.26A 5izjB-1kobA:
25.4		 5izjB-1kobA:
26.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)		 1kob TWITCHIN
(Aplysia
californica) 		4 / 7 GLY A  60
GLY A  62
VAL A  67
LYS A  82
 None
 0.43A 5izjA-1kobA:
25.5		 5izjA-1kobA:
26.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)		 1kob TWITCHIN
(Aplysia
californica) 		4 / 7 GLY A  60
GLY A  62
VAL A  67
LYS A  82
 None
 0.40A 5j5xA-1kobA:
24.6		 5j5xA-1kobA:
26.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA504_1
(CYTOCHROME P450 2C9)		 1kob TWITCHIN
(Aplysia
californica) 		4 / 8 PHE A 136
ILE A 331
THR A 213
PHE A 216
 None
 0.92A 5x23A-1kobA:
0.0		 5x23A-1kobA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YWM_X_NIOX403_0
(CASEIN KINASE II
SUBUNIT ALPHA')		 1kob TWITCHIN
(Aplysia
californica) 		4 / 7 VAL A  67
VAL A  80
LYS A  82
ILE A 111
 None
 0.56A 5ywmX-1kobA:
23.7		 5ywmX-1kobA:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZNI_A_YMZA302_0
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1kob TWITCHIN
(Aplysia
californica) 		5 / 9 VAL A  78
GLY A 346
TYR A  26
GLY A  60
PRO A 341
 None
 1.25A 5zniA-1kobA:
undetectable		 5zniA-1kobA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1kob TWITCHIN
(Aplysia
californica) 		3 / 3 LEU A 297
GLY A 237
PHE A 269
 None
 0.57A 6exiC-1kobA:
undetectable		 6exiC-1kobA:
13.05