SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1koe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIN_A_KTNA801_1
(CYTOCHROME P450
107A1)		 1koe ENDOSTATIN
(Mus
musculus) 		5 / 11 SER A 285
ALA A 229
VAL A 239
ALA A 145
LEU A 210
 None
 0.87A 1jinA-1koeA:
0.0		 1jinA-1koeA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_SAMA201_0
(UPF0066 PROTEIN
AF_0241)		 1koe ENDOSTATIN
(Mus
musculus) 		5 / 12 ALA A 280
PRO A 256
GLY A 223
LEU A 217
SER A 285
 None
 1.35A 2nv4A-1koeA:
undetectable		 2nv4A-1koeA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGL_A_GLYA301_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 1koe ENDOSTATIN
(Mus
musculus) 		4 / 8 ALA A 293
GLY A 278
THR A 277
GLN A 279
 None
 0.91A 3rglA-1koeA:
undetectable		 3rglA-1koeA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGJ_A_1PQA304_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1koe ENDOSTATIN
(Mus
musculus) 		4 / 8 ILE A 231
PHE A 180
TRP A 214
GLY A 223
 None
 1.00A 4fgjA-1koeA:
undetectable
4fgjB-1koeA:
undetectable		 4fgjA-1koeA:
21.86
4fgjB-1koeA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		 1koe ENDOSTATIN
(Mus
musculus) 		4 / 8 SER A 182
LEU A 188
PHE A 218
GLN A 291
 None
 1.18A 4j7uD-1koeA:
undetectable		 4j7uD-1koeA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_B_BRLB501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1koe ENDOSTATIN
(Mus
musculus) 		4 / 6 ILE A 202
ILE A 301
ILE A 305
LEU A 217
 None
 0.70A 4o8fB-1koeA:
undetectable		 4o8fB-1koeA:
19.49