SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1kol'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JGS_A_SALA256_1
(MULTIPLE ANTIBIOTIC
RESISTANCE PROTEIN
MARR)		 1kol FORMALDEHYDE
DEHYDROGENASE
(Pseudomonas
putida) 		4 / 7 VAL A  91
LEU A 148
LEU A 151
VAL A  41
 None
 0.73A 1jgsA-1kolA:
0.0		 1jgsA-1kolA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_1
(LIVER
CARBOXYLESTERASE I)		 1kol FORMALDEHYDE
DEHYDROGENASE
(Pseudomonas
putida) 		5 / 12 LEU A 223
VAL A 289
LEU A 236
LEU A 242
LEU A 286
 None
None
NAD  A1403 ( 4.4A)
SO4  A1003 (-4.5A)
None
 1.17A 1mx1E-1kolA:
undetectable		 1mx1E-1kolA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1kol FORMALDEHYDE
DEHYDROGENASE
(Pseudomonas
putida) 		4 / 5 LEU A 250
VAL A 255
CYH A 257
ALA A 181
 None
 1.19A 1mz9D-1kolA:
0.0		 1mz9D-1kolA:
7.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1kol FORMALDEHYDE
DEHYDROGENASE
(Pseudomonas
putida) 		4 / 4 LEU A 250
VAL A 255
CYH A 257
ALA A 181
 None
 1.22A 1mz9E-1kolA:
0.0		 1mz9E-1kolA:
7.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_A_DVAA8_0
(GRAMICIDIN A)		 1kol FORMALDEHYDE
DEHYDROGENASE
(Pseudomonas
putida) 		4 / 4 GLY A 124
VAL A 126
TRP A 131
GLY A 121
 None
 1.34A 1ng8A-1kolA:
undetectable		 1ng8A-1kolA:
4.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_A_DVAA8_0
(GRAMICIDIN A)		 1kol FORMALDEHYDE
DEHYDROGENASE
(Pseudomonas
putida) 		4 / 4 GLY A 124
VAL A 126
TRP A 131
GLY A 129
 None
 1.35A 1ng8A-1kolA:
undetectable		 1ng8A-1kolA:
4.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_B_DVAB8_0
(GRAMICIDIN A)		 1kol FORMALDEHYDE
DEHYDROGENASE
(Pseudomonas
putida) 		4 / 4 GLY A 124
VAL A 126
TRP A 131
GLY A 121
 None
 1.34A 1ng8B-1kolA:
undetectable		 1ng8B-1kolA:
4.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_B_DVAB8_0
(GRAMICIDIN A)		 1kol FORMALDEHYDE
DEHYDROGENASE
(Pseudomonas
putida) 		4 / 4 GLY A 124
VAL A 126
TRP A 131
GLY A 129
 None
 1.35A 1ng8B-1kolA:
undetectable		 1ng8B-1kolA:
4.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7J_A_478A200_1
(POL POLYPROTEIN)		 1kol FORMALDEHYDE
DEHYDROGENASE
(Pseudomonas
putida) 		6 / 11 LEU A  65
ALA A 372
ASP A 371
ASP A 370
VAL A  16
VAL A   6
 None
 1.45A 1t7jA-1kolA:
undetectable		 1t7jA-1kolA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_2
(POL POLYPROTEIN)		 1kol FORMALDEHYDE
DEHYDROGENASE
(Pseudomonas
putida) 		3 / 3 ASP A 169
VAL A  91
PRO A 142
 ZN  A1001 ( 2.5A)
None
None
 0.65A 2avvA-1kolA:
undetectable		 2avvA-1kolA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_B_ACTB1463_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 1kol FORMALDEHYDE
DEHYDROGENASE
(Pseudomonas
putida) 		4 / 7 ALA A 261
VAL A 259
GLY A 174
THR A 173
 NAD  A1403 (-4.9A)
None
None
NAD  A1403 (-3.1A)
 0.75A 2xrzB-1kolA:
1.6		 2xrzB-1kolA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_0
(REPRESSOR PROTEIN
MPHR(A))		 1kol FORMALDEHYDE
DEHYDROGENASE
(Pseudomonas
putida) 		5 / 12 GLY A 133
TYR A 125
SER A  48
ILE A 389
SER A  42
 None
None
NAD  A1403 (-2.7A)
None
None
 1.04A 3frqB-1kolA:
undetectable		 3frqB-1kolA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_B_CHDB2_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1kol FORMALDEHYDE
DEHYDROGENASE
(Pseudomonas
putida) 		3 / 3 LEU A 164
LEU A 167
ARG A 345
 None
 0.73A 3hcnB-1kolA:
2.7		 3hcnB-1kolA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_1
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 1kol FORMALDEHYDE
DEHYDROGENASE
(Pseudomonas
putida) 		3 / 3 ARG A 222
ASP A  49
GLN A 337
 NAD  A1403 (-3.2A)
None
NAD  A1403 (-4.3A)
 0.87A 3lcvB-1kolA:
3.4		 3lcvB-1kolA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1kol FORMALDEHYDE
DEHYDROGENASE
(Pseudomonas
putida) 		5 / 12 TYR A 302
GLY A 300
GLY A  47
SER A  48
ALA A 192
 None
NAD  A1403 ( 3.7A)
NAD  A1403 (-3.1A)
NAD  A1403 (-2.7A)
NAD  A1403 ( 4.1A)
 1.11A 3ou7B-1kolA:
6.2		 3ou7B-1kolA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1475_0
(MJ0495-LIKE PROTEIN)		 1kol FORMALDEHYDE
DEHYDROGENASE
(Pseudomonas
putida) 		4 / 8 ILE A 367
ILE A 389
VAL A   6
GLY A  66
 None
 0.82A 4ac9C-1kolA:
2.7		 4ac9C-1kolA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_A_ADNA401_1
(ADENOSINE KINASE)		 1kol FORMALDEHYDE
DEHYDROGENASE
(Pseudomonas
putida) 		5 / 12 GLY A 198
ALA A 192
LEU A 223
GLY A 263
ASP A 260
 None
NAD  A1403 ( 4.1A)
None
NAD  A1403 ( 4.0A)
None
 1.00A 4dc3A-1kolA:
4.9		 4dc3A-1kolA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_1
(DIPEPTIDYL PEPTIDASE
4)		 1kol FORMALDEHYDE
DEHYDROGENASE
(Pseudomonas
putida) 		5 / 12 ARG A  54
GLU A 265
GLY A  55
VAL A 282
VAL A 262
 None
None
None
NAD  A1403 (-4.7A)
NAD  A1403 (-3.6A)
 1.43A 4ffwA-1kolA:
undetectable		 4ffwA-1kolA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_1
(DIPEPTIDYL PEPTIDASE
4)		 1kol FORMALDEHYDE
DEHYDROGENASE
(Pseudomonas
putida) 		5 / 12 GLY A 195
SER A 285
VAL A 289
TYR A 190
HIS A 269
 NAD  A1403 (-3.4A)
None
None
None
SO4  A1003 ( 3.9A)
 1.28A 4ffwA-1kolA:
undetectable		 4ffwA-1kolA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_1
(DIPEPTIDYL PEPTIDASE
4)		 1kol FORMALDEHYDE
DEHYDROGENASE
(Pseudomonas
putida) 		5 / 12 GLY A 195
SER A 285
VAL A 289
TYR A 190
HIS A 269
 NAD  A1403 (-3.4A)
None
None
None
SO4  A1003 ( 3.9A)
 1.29A 4ffwB-1kolA:
undetectable		 4ffwB-1kolA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1Q_A_T27A601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 1kol FORMALDEHYDE
DEHYDROGENASE
(Pseudomonas
putida) 		5 / 12 LEU A 249
VAL A 255
VAL A 212
TYR A 190
PRO A 253
 None
 1.09A 4g1qA-1kolA:
1.1		 4g1qA-1kolA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HXY_B_ACAB502_1
(PLM1)		 1kol FORMALDEHYDE
DEHYDROGENASE
(Pseudomonas
putida) 		4 / 7 VAL A 262
SER A 285
LEU A 218
ASP A 217
 NAD  A1403 (-3.6A)
None
None
NAD  A1403 (-2.9A)
 1.14A 4hxyB-1kolA:
undetectable		 4hxyB-1kolA:
25.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ID5_A_T27A601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 1kol FORMALDEHYDE
DEHYDROGENASE
(Pseudomonas
putida) 		5 / 12 LEU A 249
VAL A 255
VAL A 212
TYR A 190
PRO A 253
 None
 1.08A 4id5A-1kolA:
0.0		 4id5A-1kolA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFV_A_T27A601_1
(EXORIBONUCLEASE H,
P66 RT)		 1kol FORMALDEHYDE
DEHYDROGENASE
(Pseudomonas
putida) 		5 / 12 LEU A 249
VAL A 255
VAL A 212
TYR A 190
PRO A 253
 None
 1.10A 4ifvA-1kolA:
0.0		 4ifvA-1kolA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFY_A_T27A601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 1kol FORMALDEHYDE
DEHYDROGENASE
(Pseudomonas
putida) 		5 / 12 LEU A 249
VAL A 255
VAL A 212
TYR A 190
PRO A 253
 None
 1.09A 4ifyA-1kolA:
1.3		 4ifyA-1kolA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IG3_A_T27A601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 1kol FORMALDEHYDE
DEHYDROGENASE
(Pseudomonas
putida) 		5 / 12 LEU A 249
VAL A 255
VAL A 212
TYR A 190
PRO A 253
 None
 1.09A 4ig3A-1kolA:
0.0		 4ig3A-1kolA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_A_IMNA201_1
(TRANSTHYRETIN)		 1kol FORMALDEHYDE
DEHYDROGENASE
(Pseudomonas
putida) 		3 / 3 LYS A 329
LEU A 325
ALA A 328
 None
 0.72A 4ikiA-1kolA:
0.0		 4ikiA-1kolA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J14_A_X2NA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 1kol FORMALDEHYDE
DEHYDROGENASE
(Pseudomonas
putida) 		5 / 10 ALA A 346
LEU A 347
ILE A 358
ALA A 200
ALA A 205
 None
 1.04A 4j14A-1kolA:
0.0		 4j14A-1kolA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KFB_A_T27A607_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H,
EXORIBONUCLEA P66 RT)		 1kol FORMALDEHYDE
DEHYDROGENASE
(Pseudomonas
putida) 		5 / 12 LEU A 249
VAL A 255
VAL A 212
TYR A 190
PRO A 253
 None
 1.08A 4kfbA-1kolA:
0.0		 4kfbA-1kolA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_B_BEZB601_0
(BENZOATE-COENZYME A
LIGASE)		 1kol FORMALDEHYDE
DEHYDROGENASE
(Pseudomonas
putida) 		5 / 8 ALA A 261
PRO A 299
GLY A 198
ALA A 200
GLY A 174
 NAD  A1403 (-4.9A)
NAD  A1403 (-4.8A)
None
None
None
 1.40A 4zjzB-1kolA:
5.4		 4zjzB-1kolA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DNU_A_BEZA319_0
(SHKAI2IB)		 1kol FORMALDEHYDE
DEHYDROGENASE
(Pseudomonas
putida) 		4 / 5 GLN A 135
ILE A  45
ILE A 367
TYR A 376
 None
 1.15A 5dnuA-1kolA:
undetectable		 5dnuA-1kolA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DNV_A_BEZA304_0
(SHKAI2IB)		 1kol FORMALDEHYDE
DEHYDROGENASE
(Pseudomonas
putida) 		4 / 5 GLN A 135
ILE A  45
ILE A 367
TYR A 376
 None
 1.14A 5dnvA-1kolA:
undetectable		 5dnvA-1kolA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1kol FORMALDEHYDE
DEHYDROGENASE
(Pseudomonas
putida) 		3 / 3 LEU A 236
TYR A 190
SER A 285
 NAD  A1403 ( 4.4A)
None
None
 0.72A 5iktA-1kolA:
0.0		 5iktA-1kolA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 1kol FORMALDEHYDE
DEHYDROGENASE
(Pseudomonas
putida) 		4 / 6 LEU A 242
VAL A 289
LEU A 286
VAL A 255
 SO4  A1003 (-4.5A)
None
None
None
 0.98A 5x7zA-1kolA:
undetectable		 5x7zA-1kolA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		 1kol FORMALDEHYDE
DEHYDROGENASE
(Pseudomonas
putida) 		5 / 12 GLY A 133
LEU A  65
VAL A   6
GLY A 120
ASP A  49
 None
 1.15A 6gngA-1kolA:
3.9		 6gngA-1kolA:
21.07