SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1kp0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_C_9CRC502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1kp0 CREATINE
AMIDINOHYDROLASE
(Actinobacillus) 		5 / 10 ALA A 117
SER A 108
LEU A 135
ALA A 138
ILE A 120
 None
 1.27A 1g5yC-1kp0A:
undetectable		 1g5yC-1kp0A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_D_THAD4_2
(LIVER
CARBOXYLESTERASE I)		 1kp0 CREATINE
AMIDINOHYDROLASE
(Actinobacillus) 		3 / 3 PHE A  19
LEU A 165
MET A 252
 None
 0.90A 1mx1D-1kp0A:
undetectable		 1mx1D-1kp0A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_A_PXLA1003_1
(PYRIDOXINE KINASE)		 1kp0 CREATINE
AMIDINOHYDROLASE
(Actinobacillus) 		4 / 8 VAL A  43
VAL A 147
HIS A  49
ASP A 146
 None
 1.08A 2ddwA-1kp0A:
undetectable		 2ddwA-1kp0A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA508_0
(CHORISMATE SYNTHASE)		 1kp0 CREATINE
AMIDINOHYDROLASE
(Actinobacillus) 		4 / 5 LEU A 139
ARG A 132
ALA A 138
ILE A 122
 None
 1.16A 2qhfA-1kp0A:
0.0		 2qhfA-1kp0A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE503_1
(PHOSPHOLIPASE A2)		 1kp0 CREATINE
AMIDINOHYDROLASE
(Actinobacillus) 		5 / 11 LEU A 288
GLY A 287
ILE A 300
PRO A 293
THR A 385
 None
 1.35A 3bjwE-1kp0A:
undetectable		 3bjwE-1kp0A:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1kp0 CREATINE
AMIDINOHYDROLASE
(Actinobacillus) 		4 / 7 MET A 215
ARG A  90
ILE A 205
PHE A 254
 None
 1.42A 3e7gA-1kp0A:
undetectable
3e7gB-1kp0A:
undetectable		 3e7gA-1kp0A:
20.31
3e7gB-1kp0A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_B_H4BB1902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1kp0 CREATINE
AMIDINOHYDROLASE
(Actinobacillus) 		4 / 7 PHE A 254
MET A 215
ARG A  90
ILE A 205
 None
 1.40A 3e7gA-1kp0A:
undetectable
3e7gB-1kp0A:
undetectable		 3e7gA-1kp0A:
20.31
3e7gB-1kp0A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_C_H4BC2902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1kp0 CREATINE
AMIDINOHYDROLASE
(Actinobacillus) 		4 / 7 MET A 215
ARG A  90
ILE A 205
PHE A 254
 None
 1.38A 3e7gC-1kp0A:
0.0
3e7gD-1kp0A:
0.0		 3e7gC-1kp0A:
20.31
3e7gD-1kp0A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_D_H4BD3902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1kp0 CREATINE
AMIDINOHYDROLASE
(Actinobacillus) 		4 / 8 PHE A 254
MET A 215
ARG A  90
ILE A 205
 None
 1.38A 3e7gC-1kp0A:
0.0
3e7gD-1kp0A:
0.0		 3e7gC-1kp0A:
20.31
3e7gD-1kp0A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EJ8_A_H4BA1902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1kp0 CREATINE
AMIDINOHYDROLASE
(Actinobacillus) 		4 / 7 MET A 215
ARG A  90
ILE A 205
PHE A 254
 None
 1.39A 3ej8A-1kp0A:
0.0
3ej8B-1kp0A:
0.0		 3ej8A-1kp0A:
20.31
3ej8B-1kp0A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EJ8_C_H4BC3902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1kp0 CREATINE
AMIDINOHYDROLASE
(Actinobacillus) 		4 / 7 MET A 215
ARG A  90
ILE A 205
PHE A 254
 None
 1.45A 3ej8C-1kp0A:
0.0
3ej8D-1kp0A:
0.0		 3ej8C-1kp0A:
20.31
3ej8D-1kp0A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EJ8_D_H4BD4902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1kp0 CREATINE
AMIDINOHYDROLASE
(Actinobacillus) 		4 / 7 PHE A 254
MET A 215
ARG A  90
ILE A 205
 None
 1.41A 3ej8C-1kp0A:
0.0
3ej8D-1kp0A:
0.0		 3ej8C-1kp0A:
20.31
3ej8D-1kp0A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_1
(CYTOCHROME P450 3A4)		 1kp0 CREATINE
AMIDINOHYDROLASE
(Actinobacillus) 		5 / 12 SER A  55
ILE A  51
ALA A  67
ILE A  96
GLY A  84
 None
 1.08A 3nxuA-1kp0A:
0.1		 3nxuA-1kp0A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 1kp0 CREATINE
AMIDINOHYDROLASE
(Actinobacillus) 		3 / 3 ARG A 262
TRP A 277
GLY A 394
 None
 0.99A 4e7cA-1kp0A:
0.0		 4e7cA-1kp0A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM0_A_CP6A201_1
(DIHYDROFOLATE
REDUCTASE)		 1kp0 CREATINE
AMIDINOHYDROLASE
(Actinobacillus) 		5 / 10 ILE A 175
ALA A 179
THR A 217
LEU A 214
ILE A 172
 None
 1.26A 4km0A-1kp0A:
undetectable		 4km0A-1kp0A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L64_A_C2FA802_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 1kp0 CREATINE
AMIDINOHYDROLASE
(Actinobacillus) 		4 / 7 SER A  79
TYR A  66
ARG A  64
VAL A  97
 None
 1.37A 4l64A-1kp0A:
undetectable		 4l64A-1kp0A:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_B_H4BB1011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 1kp0 CREATINE
AMIDINOHYDROLASE
(Actinobacillus) 		4 / 7 PHE A 254
MET A 215
ARG A  90
ILE A 205
 None
 1.40A 4nosA-1kp0A:
0.0
4nosB-1kp0A:
undetectable		 4nosA-1kp0A:
20.58
4nosB-1kp0A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_C_H4BC2011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 1kp0 CREATINE
AMIDINOHYDROLASE
(Actinobacillus) 		4 / 7 MET A 215
ARG A  90
ILE A 205
PHE A 254
 None
 1.33A 4nosC-1kp0A:
0.0
4nosD-1kp0A:
0.0		 4nosC-1kp0A:
20.58
4nosD-1kp0A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YSH_B_GLYB402_0
(GLYCINE OXIDASE)		 1kp0 CREATINE
AMIDINOHYDROLASE
(Actinobacillus) 		4 / 5 GLU A  23
TYR A  53
ARG A  30
ARG A  26
 None
 1.43A 4yshB-1kp0A:
0.0		 4yshB-1kp0A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_A_BEZA201_0
(HYDROXYNITRILE LYASE)		 1kp0 CREATINE
AMIDINOHYDROLASE
(Actinobacillus) 		5 / 9 VAL A 114
VAL A  69
ILE A 122
PHE A 144
LEU A 139
 None
 1.25A 5e4dA-1kp0A:
0.0		 5e4dA-1kp0A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB201_0
(HYDROXYNITRILE LYASE)		 1kp0 CREATINE
AMIDINOHYDROLASE
(Actinobacillus) 		5 / 11 VAL A 114
VAL A 110
ILE A 122
PHE A 144
LEU A 139
 None
 1.07A 5e4dB-1kp0A:
0.0		 5e4dB-1kp0A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 1kp0 CREATINE
AMIDINOHYDROLASE
(Actinobacillus) 		5 / 12 ILE A 184
ALA A 181
GLY A 242
GLY A 187
VAL A 239
 None
 0.98A 5i71A-1kp0A:
0.0		 5i71A-1kp0A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 1kp0 CREATINE
AMIDINOHYDROLASE
(Actinobacillus) 		5 / 12 ILE A 184
ALA A 181
GLY A 242
GLY A 187
VAL A 239
 None
 0.90A 5i73A-1kp0A:
undetectable		 5i73A-1kp0A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 1kp0 CREATINE
AMIDINOHYDROLASE
(Actinobacillus) 		5 / 12 ILE A 184
ALA A 181
GLY A 242
GLY A 187
VAL A 239
 None
 0.96A 5i75A-1kp0A:
0.0		 5i75A-1kp0A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W5V_A_ANWA701_0
(SERINE/THREONINE-PRO
TEIN KINASE TBK1)		 1kp0 CREATINE
AMIDINOHYDROLASE
(Actinobacillus) 		5 / 9 LEU A 260
ALA A 170
GLY A 176
THR A 180
MET A 201
 None
 1.40A 5w5vA-1kp0A:
undetectable		 5w5vA-1kp0A:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1kp0 CREATINE
AMIDINOHYDROLASE
(Actinobacillus) 		3 / 3 SER A 355
HIS A 323
TYR A 257
 None
 0.90A 5y2tA-1kp0A:
0.0		 5y2tA-1kp0A:
undetectable