SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1kp2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMI_A_BHSA1610_1
(NITRIC OXIDE
SYNTHASE)		 1kp2 ARGININOSUCCINATE
SYNTHETASE
(Escherichia
coli) 		4 / 8 ARG A 106
ALA A  16
TRP A 125
PHE A 139
 ATP  A 459 ( 4.0A)
ATP  A 459 (-3.2A)
None
ATP  A 459 (-4.5A)
 1.12A 1dmiA-1kp2A:
0.0
1dmiB-1kp2A:
0.0		 1dmiA-1kp2A:
21.47
1dmiB-1kp2A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDW_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 1kp2 ARGININOSUCCINATE
SYNTHETASE
(Escherichia
coli) 		5 / 10 VAL A 238
LEU A 298
PRO A 245
PHE A 240
GLU A 304
 None
 1.45A 1fdwA-1kp2A:
3.3		 1fdwA-1kp2A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE9_A_BEZA352_0
(D-AMINO ACID OXIDASE)		 1kp2 ARGININOSUCCINATE
SYNTHETASE
(Escherichia
coli) 		4 / 5 TYR A 319
TYR A 303
ILE A  84
GLY A 323
 None
 1.09A 1ve9A-1kp2A:
3.2		 1ve9A-1kp2A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_2
(THYROID HORMONE
RECEPTOR BETA-1)		 1kp2 ARGININOSUCCINATE
SYNTHETASE
(Escherichia
coli) 		3 / 3 PHE A  99
ARG A 328
ASN A  91
 None
 0.88A 1xzxX-1kp2A:
undetectable		 1xzxX-1kp2A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9W_A_PAUA6001_0
(PANTOTHENATE KINASE)		 1kp2 ARGININOSUCCINATE
SYNTHETASE
(Escherichia
coli) 		5 / 11 ASN A 373
VAL A 375
GLY A 357
ARG A 239
THR A 360
 None
 1.44A 2f9wA-1kp2A:
0.1
2f9wB-1kp2A:
2.1		 2f9wA-1kp2A:
20.75
2f9wB-1kp2A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GLU_B_SAMB302_0
(YCGJ)		 1kp2 ARGININOSUCCINATE
SYNTHETASE
(Escherichia
coli) 		5 / 12 GLY A 273
GLY A 271
HIS A 270
ALA A 297
PHE A  99
 None
 1.03A 2gluB-1kp2A:
2.1		 2gluB-1kp2A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1357_1
(PROSTAGLANDIN
REDUCTASE 2)		 1kp2 ARGININOSUCCINATE
SYNTHETASE
(Escherichia
coli) 		4 / 6 TYR A  98
LEU A 197
ASN A 195
ASP A  48
 PO4  A 456 (-4.5A)
None
None
None
 1.39A 2w98A-1kp2A:
5.9
2w98B-1kp2A:
5.9		 2w98A-1kp2A:
23.40
2w98B-1kp2A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 1kp2 ARGININOSUCCINATE
SYNTHETASE
(Escherichia
coli) 		4 / 6 TYR A 291
PRO A 103
ILE A 282
ASN A  91
 None
PO4  A 456 (-4.1A)
None
None
 1.39A 2wekB-1kp2A:
6.5		 2wekB-1kp2A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_A_PAUA248_0
(TYPE III
PANTOTHENATE KINASE)		 1kp2 ARGININOSUCCINATE
SYNTHETASE
(Escherichia
coli) 		5 / 10 ASN A 373
VAL A 375
GLY A 357
ARG A 239
THR A 360
 None
 1.50A 3bexA-1kp2A:
2.0
3bexB-1kp2A:
1.7		 3bexA-1kp2A:
19.78
3bexB-1kp2A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC59_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 1kp2 ARGININOSUCCINATE
SYNTHETASE
(Escherichia
coli) 		3 / 3 GLY A 268
GLY A 273
GLY A 271
 None
 0.40A 3bogC-1kp2A:
undetectable		 3bogC-1kp2A:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D41_A_FCNA4001_1
(FOMA PROTEIN)		 1kp2 ARGININOSUCCINATE
SYNTHETASE
(Escherichia
coli) 		5 / 8 GLY A 366
GLY A 271
GLY A 268
HIS A 270
ILE A 266
 None
 1.18A 3d41A-1kp2A:
3.0		 3d41A-1kp2A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_1
(CYTOCHROME P450 2R1)		 1kp2 ARGININOSUCCINATE
SYNTHETASE
(Escherichia
coli) 		4 / 5 ALA A 352
LEU A 306
GLY A 357
THR A 252
 None
 0.93A 3dl9A-1kp2A:
0.0		 3dl9A-1kp2A:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA277_0
(UNIVERSAL STRESS
PROTEIN)		 1kp2 ARGININOSUCCINATE
SYNTHETASE
(Escherichia
coli) 		3 / 3 ASP A 127
SER A 129
ARG A 106
 None
ATP  A 459 (-4.7A)
ATP  A 459 ( 4.0A)
 0.76A 3loqA-1kp2A:
7.1		 3loqA-1kp2A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_0
(2'-O-METHYL
TRANSFERASE)		 1kp2 ARGININOSUCCINATE
SYNTHETASE
(Escherichia
coli) 		5 / 12 GLY A 221
PRO A  47
ASN A 217
ASP A 226
PHE A 224
 None
 1.30A 3r24A-1kp2A:
2.1		 3r24A-1kp2A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SGL_A_SAMA692_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 1kp2 ARGININOSUCCINATE
SYNTHETASE
(Escherichia
coli) 		5 / 12 GLY A 267
GLY A 271
TYR A 369
VAL A 236
GLY A 295
 None
 1.04A 3sglA-1kp2A:
3.8		 3sglA-1kp2A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYS_A_ACTA402_0
(MCCC FAMILY PROTEIN)		 1kp2 ARGININOSUCCINATE
SYNTHETASE
(Escherichia
coli) 		4 / 6 ASP A 127
SER A 129
ASP A 135
ARG A 106
 None
ATP  A 459 (-4.7A)
ATP  A 459 (-3.5A)
ATP  A 459 ( 4.0A)
 1.03A 4eysA-1kp2A:
undetectable		 4eysA-1kp2A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_A_KANA301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1kp2 ARGININOSUCCINATE
SYNTHETASE
(Escherichia
coli) 		5 / 12 ASP A 135
ARG A 106
GLU A 207
ASP A 193
SER A 287
 ATP  A 459 (-3.5A)
ATP  A 459 ( 4.0A)
None
ATP  A 459 (-2.8A)
None
 1.49A 4feuA-1kp2A:
0.7
4feuB-1kp2A:
0.0		 4feuA-1kp2A:
20.13
4feuB-1kp2A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_B_ASWB1301_1
(DNA TOPOISOMERASE
2-BETA)		 1kp2 ARGININOSUCCINATE
SYNTHETASE
(Escherichia
coli) 		4 / 7 ILE A  81
GLY A 105
ALA A  83
GLN A  46
 None
 0.98A 4g0uB-1kp2A:
undetectable		 4g0uB-1kp2A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1kp2 ARGININOSUCCINATE
SYNTHETASE
(Escherichia
coli) 		5 / 12 ILE A  15
ALA A  64
ALA A  25
LEU A   7
ILE A  13
 None
 0.98A 4kjjA-1kp2A:
undetectable		 4kjjA-1kp2A:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA207_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 1kp2 ARGININOSUCCINATE
SYNTHETASE
(Escherichia
coli) 		5 / 12 GLU A  79
ALA A 107
ARG A 344
ALA A 340
ALA A  88
 None
 1.08A 4oaeA-1kp2A:
undetectable		 4oaeA-1kp2A:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA207_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 1kp2 ARGININOSUCCINATE
SYNTHETASE
(Escherichia
coli) 		5 / 12 GLU A  79
ARG A 344
ALA A 340
ALA A  88
GLY A 327
 None
 1.09A 4oaeA-1kp2A:
undetectable		 4oaeA-1kp2A:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB307_1
(CHITOSANASE)		 1kp2 ARGININOSUCCINATE
SYNTHETASE
(Escherichia
coli) 		4 / 7 THR A  92
GLY A  95
THR A  97
HIS A 320
 None
 0.71A 4qwpB-1kp2A:
0.0		 4qwpB-1kp2A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_H_377H401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1kp2 ARGININOSUCCINATE
SYNTHETASE
(Escherichia
coli) 		4 / 6 TYR A 331
ASN A 100
GLU A 279
GLU A 202
 PO4  A 456 (-4.6A)
None
PO4  A 456 (-3.7A)
PO4  A 456 (-3.3A)
 1.37A 4twdG-1kp2A:
0.0
4twdH-1kp2A:
0.0		 4twdG-1kp2A:
20.27
4twdH-1kp2A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 1kp2 ARGININOSUCCINATE
SYNTHETASE
(Escherichia
coli) 		5 / 12 TYR A 142
GLY A 333
GLY A 110
LEU A 113
GLY A 133
 None
None
None
None
ATP  A 459 ( 4.4A)
 1.12A 5i75A-1kp2A:
0.0		 5i75A-1kp2A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 1kp2 ARGININOSUCCINATE
SYNTHETASE
(Escherichia
coli) 		4 / 6 GLY A 327
ASP A 135
ILE A 283
TYR A  98
 None
ATP  A 459 (-3.5A)
None
PO4  A 456 (-4.5A)
 1.13A 5iwuA-1kp2A:
0.0		 5iwuA-1kp2A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BER_A_DVAA2_0
(E(DVA)DP(DGL)(DHI)(D
PR)N(DAL)(DPR))		 1kp2 ARGININOSUCCINATE
SYNTHETASE
(Escherichia
coli) 		3 / 3 GLU A 164
ASP A 158
PRO A 155
 None
 0.45A 6berA-1kp2A:
undetectable		 6berA-1kp2A:
3.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1kp2 ARGININOSUCCINATE
SYNTHETASE
(Escherichia
coli) 		3 / 3 LEU A 197
GLY A 295
PHE A 240
 None
 0.65A 6exiC-1kp2A:
3.0		 6exiC-1kp2A:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_D95A816_0
(GEPHYRIN)		 1kp2 ARGININOSUCCINATE
SYNTHETASE
(Escherichia
coli) 		5 / 11 PHE A 161
ILE A 162
LEU A 165
LEU A   7
ILE A  15
 None
 1.44A 6fgcA-1kp2A:
undetectable		 6fgcA-1kp2A:
12.81