SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1kpb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZS9_A_PAUA603_0
(PANTOTHENATE KINASE)		 1kpb HUMAN PROTEIN KINASE
C INTERACTING
PROTEIN 1 (ZINC
PROTEIN)
(Homo
sapiens) 		4 / 6 VAL A  54
ASP A  35
LYS A  83
HIS A  76
 None
 1.16A 2zs9A-1kpbA:
undetectable		 2zs9A-1kpbA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_C_PAUC248_0
(TYPE III
PANTOTHENATE KINASE)		 1kpb HUMAN PROTEIN KINASE
C INTERACTING
PROTEIN 1 (ZINC
PROTEIN)
(Homo
sapiens) 		5 / 11 VAL A 115
GLY A  81
ILE A  32
THR A  50
LEU A  88
 None
 1.18A 3bexC-1kpbA:
undetectable
3bexD-1kpbA:
undetectable		 3bexC-1kpbA:
19.76
3bexD-1kpbA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_F_PAUF248_0
(TYPE III
PANTOTHENATE KINASE)		 1kpb HUMAN PROTEIN KINASE
C INTERACTING
PROTEIN 1 (ZINC
PROTEIN)
(Homo
sapiens) 		5 / 11 THR A  50
LEU A  88
VAL A 115
GLY A  81
ILE A  32
 None
 1.18A 3bexE-1kpbA:
undetectable
3bexF-1kpbA:
undetectable		 3bexE-1kpbA:
19.76
3bexF-1kpbA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_A_PAUA248_0
(TYPE III
PANTOTHENATE KINASE)		 1kpb HUMAN PROTEIN KINASE
C INTERACTING
PROTEIN 1 (ZINC
PROTEIN)
(Homo
sapiens) 		5 / 11 VAL A 115
GLY A  81
ILE A  32
THR A  50
LEU A  88
 None
 1.19A 3bf1A-1kpbA:
undetectable
3bf1B-1kpbA:
undetectable		 3bf1A-1kpbA:
19.76
3bf1B-1kpbA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_B_PAUB248_0
(TYPE III
PANTOTHENATE KINASE)		 1kpb HUMAN PROTEIN KINASE
C INTERACTING
PROTEIN 1 (ZINC
PROTEIN)
(Homo
sapiens) 		6 / 12 THR A  50
LEU A  88
VAL A 115
VAL A  80
GLY A  81
ILE A  32
 None
 1.32A 3bf1A-1kpbA:
undetectable
3bf1B-1kpbA:
undetectable		 3bf1A-1kpbA:
19.76
3bf1B-1kpbA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_C_PAUC248_0
(TYPE III
PANTOTHENATE KINASE)		 1kpb HUMAN PROTEIN KINASE
C INTERACTING
PROTEIN 1 (ZINC
PROTEIN)
(Homo
sapiens) 		5 / 11 VAL A 115
GLY A  81
ILE A  32
THR A  50
LEU A  88
 None
 1.19A 3bf1C-1kpbA:
undetectable
3bf1D-1kpbA:
undetectable		 3bf1C-1kpbA:
19.76
3bf1D-1kpbA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_D_PAUD248_0
(TYPE III
PANTOTHENATE KINASE)		 1kpb HUMAN PROTEIN KINASE
C INTERACTING
PROTEIN 1 (ZINC
PROTEIN)
(Homo
sapiens) 		5 / 11 THR A  50
LEU A  88
VAL A 115
GLY A  81
ILE A  32
 None
 1.17A 3bf1C-1kpbA:
undetectable
3bf1D-1kpbA:
undetectable		 3bf1C-1kpbA:
19.76
3bf1D-1kpbA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_E_PAUE248_0
(TYPE III
PANTOTHENATE KINASE)		 1kpb HUMAN PROTEIN KINASE
C INTERACTING
PROTEIN 1 (ZINC
PROTEIN)
(Homo
sapiens) 		5 / 11 VAL A 115
GLY A  81
ILE A  32
THR A  50
LEU A  88
 None
 1.18A 3bf1E-1kpbA:
undetectable
3bf1F-1kpbA:
undetectable		 3bf1E-1kpbA:
19.76
3bf1F-1kpbA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_F_PAUF248_0
(TYPE III
PANTOTHENATE KINASE)		 1kpb HUMAN PROTEIN KINASE
C INTERACTING
PROTEIN 1 (ZINC
PROTEIN)
(Homo
sapiens) 		5 / 11 THR A  50
LEU A  88
VAL A 115
GLY A  81
ILE A  32
 None
 1.17A 3bf1E-1kpbA:
undetectable
3bf1F-1kpbA:
undetectable		 3bf1E-1kpbA:
19.76
3bf1F-1kpbA:
19.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3O1C_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 1kpb HUMAN PROTEIN KINASE
C INTERACTING
PROTEIN 1 (ZINC
PROTEIN)
(Homo
sapiens) 		10 / 10 ILE A  18
PHE A  19
ILE A  22
ASP A  43
ILE A  44
SER A  45
LEU A  53
SER A 107
HIS A 112
HIS A 114
 None
 0.70A 3o1cA-1kpbA:
23.5		 3o1cA-1kpbA:
95.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3O1X_A_ADNA1450_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 1kpb HUMAN PROTEIN KINASE
C INTERACTING
PROTEIN 1 (ZINC
PROTEIN)
(Homo
sapiens) 		10 / 10 ILE A  18
PHE A  19
ILE A  22
ASP A  43
ILE A  44
SER A  45
LEU A  53
SER A 107
HIS A 112
HIS A 114
 None
 0.77A 3o1xA-1kpbA:
23.5		 3o1xA-1kpbA:
95.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QGZ_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 1kpb HUMAN PROTEIN KINASE
C INTERACTING
PROTEIN 1 (ZINC
PROTEIN)
(Homo
sapiens) 		8 / 10 ILE A  18
PHE A  19
ILE A  22
ASP A  43
ILE A  44
LEU A  53
HIS A 112
HIS A 114
 None
 0.54A 3qgzA-1kpbA:
23.7		 3qgzA-1kpbA:
96.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QGZ_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 1kpb HUMAN PROTEIN KINASE
C INTERACTING
PROTEIN 1 (ZINC
PROTEIN)
(Homo
sapiens) 		8 / 10 ILE A  18
PHE A  19
ILE A  22
ASP A  43
ILE A  44
LEU A  53
SER A 107
HIS A 112
 None
 0.83A 3qgzA-1kpbA:
23.7		 3qgzA-1kpbA:
96.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QGZ_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 1kpb HUMAN PROTEIN KINASE
C INTERACTING
PROTEIN 1 (ZINC
PROTEIN)
(Homo
sapiens) 		8 / 10 PHE A  19
ILE A  22
ASP A  43
ILE A  44
SER A  45
LEU A  53
HIS A 112
HIS A 114
 None
 0.52A 3qgzA-1kpbA:
23.7		 3qgzA-1kpbA:
96.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QGZ_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 1kpb HUMAN PROTEIN KINASE
C INTERACTING
PROTEIN 1 (ZINC
PROTEIN)
(Homo
sapiens) 		8 / 10 PHE A  19
ILE A  22
ASP A  43
ILE A  44
SER A  45
LEU A  53
SER A 107
HIS A 112
 None
 0.76A 3qgzA-1kpbA:
23.7		 3qgzA-1kpbA:
96.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KM8_B_L8PB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 1kpb HUMAN PROTEIN KINASE
C INTERACTING
PROTEIN 1 (ZINC
PROTEIN)
(Homo
sapiens) 		5 / 8 GLN A  47
ASN A  99
GLN A 106
HIS A 112
HIS A 114
 None
 0.28A 5km8A-1kpbA:
18.6
5km8B-1kpbA:
22.1		 5km8A-1kpbA:
55.00
5km8B-1kpbA:
55.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KM8_B_L8PB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 1kpb HUMAN PROTEIN KINASE
C INTERACTING
PROTEIN 1 (ZINC
PROTEIN)
(Homo
sapiens) 		5 / 8 GLN A  47
ASN A  99
GLN A 106
SER A 107
HIS A 114
 None
 0.63A 5km8A-1kpbA:
18.6
5km8B-1kpbA:
22.1		 5km8A-1kpbA:
55.00
5km8B-1kpbA:
55.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KM9_B_ADNB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 1kpb HUMAN PROTEIN KINASE
C INTERACTING
PROTEIN 1 (ZINC
PROTEIN)
(Homo
sapiens) 		8 / 12 ILE A  18
PHE A  19
ILE A  22
ASP A  43
LEU A  53
VAL A 108
HIS A 112
HIS A 114
 None
 0.36A 5km9B-1kpbA:
22.1		 5km9B-1kpbA:
55.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KM9_B_ADNB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 1kpb HUMAN PROTEIN KINASE
C INTERACTING
PROTEIN 1 (ZINC
PROTEIN)
(Homo
sapiens) 		5 / 12 ILE A  22
PHE A  19
ILE A  55
LEU A  39
ASP A  43
 None
 1.08A 5km9B-1kpbA:
22.1		 5km9B-1kpbA:
55.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UVM_B_ADNB207_1
(HISTIDINE TRIAD
(HIT) PROTEIN)		 1kpb HUMAN PROTEIN KINASE
C INTERACTING
PROTEIN 1 (ZINC
PROTEIN)
(Homo
sapiens) 		8 / 12 PHE A  19
ILE A  22
ASP A  43
ILE A  44
LEU A  53
VAL A 108
HIS A 112
HIS A 114
 None
 0.36A 5uvmB-1kpbA:
19.9		 5uvmB-1kpbA:
35.33