SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1kps'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1kps RAN-GTPASE
ACTIVATING PROTEIN 1
(Mus
musculus) 		3 / 3 LEU B 541
PRO B 540
LEU B 544
 None
 0.52A 2po5B-1kpsB:
undetectable		 2po5B-1kpsB:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1kps RAN-GTPASE
ACTIVATING PROTEIN 1
(Mus
musculus) 		3 / 3 LEU B 541
PRO B 540
LEU B 544
 None
 0.57A 2po7B-1kpsB:
undetectable		 2po7B-1kpsB:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQ5_B_LDPB1197_1
(S-NORCOCLAURINE
SYNTHASE)		 1kps RAN-GTPASE
ACTIVATING PROTEIN 1
(Mus
musculus) 		4 / 7 LEU B 518
PHE B 514
LEU B 499
TYR B 552
 None
 0.97A 2vq5B-1kpsB:
undetectable		 2vq5B-1kpsB:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A9E_B_REAB1_1
(RETINOIC ACID
RECEPTOR ALPHA)		 1kps RAN-GTPASE
ACTIVATING PROTEIN 1
(Mus
musculus) 		6 / 11 PHE B 514
LEU B 499
PHE B 509
SER B 466
VAL B 543
LEU B 544
 None
 1.37A 3a9eB-1kpsB:
0.0		 3a9eB-1kpsB:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_A_0HKA2001_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 1kps RAN-GTPASE
ACTIVATING PROTEIN 1
(Mus
musculus) 		5 / 12 ASP B 497
THR B 465
THR B 463
ALA B 474
TYR B 552
 None
 1.41A 4u15A-1kpsB:
undetectable		 4u15A-1kpsB:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_A_0HKA1201_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 1kps RAN-GTPASE
ACTIVATING PROTEIN 1
(Mus
musculus) 		5 / 12 ASP B 497
THR B 465
THR B 463
ALA B 474
TYR B 552
 None
 1.34A 5dsgA-1kpsB:
1.2		 5dsgA-1kpsB:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_A_CVIA608_0
(ACETYLCHOLINESTERASE)		 1kps RAN-GTPASE
ACTIVATING PROTEIN 1
(Mus
musculus) 		4 / 7 TYR B 552
ASP B 497
LEU B 493
VAL B 478
 None
 1.07A 5ov9A-1kpsB:
undetectable		 5ov9A-1kpsB:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB602_0
(ACETYLCHOLINESTERASE)		 1kps RAN-GTPASE
ACTIVATING PROTEIN 1
(Mus
musculus) 		4 / 8 TYR B 552
ASP B 497
LEU B 493
VAL B 478
 None
 1.04A 5ov9B-1kpsB:
undetectable		 5ov9B-1kpsB:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UBB_A_SAMA301_0
(ALPHA N-TERMINAL
PROTEIN
METHYLTRANSFERASE 1B)		 1kps RAN-GTPASE
ACTIVATING PROTEIN 1
(Mus
musculus) 		5 / 12 MET B 500
LEU B 582
GLN B 550
VAL B 548
LEU B 586
 None
 1.26A 5ubbA-1kpsB:
undetectable		 5ubbA-1kpsB:
23.77