SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1kq0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_1
(ADENOSINE DEAMINASE)		 1kq0 METHIONINE
AMINOPEPTIDASE 2
(Homo
sapiens) 		5 / 12 PHE A 219
ALA A 362
HIS A 331
HIS A 339
ASP A 251
 MED  A 601 ( 3.9A)
ZN  A 480 ( 3.7A)
ZN  A 480 ( 3.4A)
MED  A 601 (-3.3A)
ZN  A 479 ( 1.9A)
 1.21A 1a4lA-1kq0A:
undetectable		 1a4lA-1kq0A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_1
(ADENOSINE DEAMINASE)		 1kq0 METHIONINE
AMINOPEPTIDASE 2
(Homo
sapiens) 		5 / 12 PHE A 219
ALA A 362
HIS A 331
HIS A 339
ASP A 251
 MED  A 601 ( 3.9A)
ZN  A 480 ( 3.7A)
ZN  A 480 ( 3.4A)
MED  A 601 (-3.3A)
ZN  A 479 ( 1.9A)
 1.21A 1a4lB-1kq0A:
undetectable		 1a4lB-1kq0A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_1
(ADENOSINE DEAMINASE)		 1kq0 METHIONINE
AMINOPEPTIDASE 2
(Homo
sapiens) 		5 / 12 PHE A 219
ALA A 362
HIS A 331
HIS A 339
ASP A 251
 MED  A 601 ( 3.9A)
ZN  A 480 ( 3.7A)
ZN  A 480 ( 3.4A)
MED  A 601 (-3.3A)
ZN  A 479 ( 1.9A)
 1.19A 1a4lC-1kq0A:
undetectable		 1a4lC-1kq0A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_1
(ADENOSINE DEAMINASE)		 1kq0 METHIONINE
AMINOPEPTIDASE 2
(Homo
sapiens) 		5 / 12 PHE A 219
ALA A 362
HIS A 331
HIS A 339
ASP A 251
 MED  A 601 ( 3.9A)
ZN  A 480 ( 3.7A)
ZN  A 480 ( 3.4A)
MED  A 601 (-3.3A)
ZN  A 479 ( 1.9A)
 1.28A 1a4lD-1kq0A:
undetectable		 1a4lD-1kq0A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3003_1
(SERUM ALBUMIN)		 1kq0 METHIONINE
AMINOPEPTIDASE 2
(Homo
sapiens) 		4 / 6 HIS A 460
ILE A 363
ALA A 303
VAL A 344
 None
 1.05A 1hk1A-1kq0A:
0.0		 1hk1A-1kq0A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_A_GBNA2414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 1kq0 METHIONINE
AMINOPEPTIDASE 2
(Homo
sapiens) 		4 / 8 GLY A 301
GLY A 287
THR A 284
ALA A 283
 None
 0.57A 2ej3A-1kq0A:
undetectable		 2ej3A-1kq0A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_C_GBNC1414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 1kq0 METHIONINE
AMINOPEPTIDASE 2
(Homo
sapiens) 		4 / 8 GLY A 301
GLY A 287
THR A 284
ALA A 283
 None
 0.54A 2ej3C-1kq0A:
undetectable		 2ej3C-1kq0A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_A_ACHA546_0
(ACETYLCHOLINESTERASE)		 1kq0 METHIONINE
AMINOPEPTIDASE 2
(Homo
sapiens) 		4 / 8 TYR A 444
GLU A 364
HIS A 331
GLY A 330
 MED  A 601 ( 4.7A)
ZN  A 480 (-2.6A)
ZN  A 480 ( 3.4A)
None
 0.82A 2ha4A-1kq0A:
undetectable		 2ha4A-1kq0A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_B_ACHB603_0
(ACETYLCHOLINESTERASE)		 1kq0 METHIONINE
AMINOPEPTIDASE 2
(Homo
sapiens) 		4 / 7 TYR A 444
GLU A 364
HIS A 331
GLY A 330
 MED  A 601 ( 4.7A)
ZN  A 480 (-2.6A)
ZN  A 480 ( 3.4A)
None
 0.80A 2ha4B-1kq0A:
undetectable		 2ha4B-1kq0A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_D_PAUD248_0
(TYPE III
PANTOTHENATE KINASE)		 1kq0 METHIONINE
AMINOPEPTIDASE 2
(Homo
sapiens) 		5 / 10 LEU A 277
THR A 266
VAL A 322
GLY A 367
ILE A 247
 None
 1.44A 3bexC-1kq0A:
undetectable
3bexD-1kq0A:
undetectable		 3bexC-1kq0A:
19.09
3bexD-1kq0A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_D_ACTD302_0
(GLUTATHIONE
TRANSFERASE GTE1)		 1kq0 METHIONINE
AMINOPEPTIDASE 2
(Homo
sapiens) 		3 / 3 TYR A 478
PHE A 252
ARG A 180
 TBU  A 501 ( 4.9A)
None
None
 0.88A 4g19D-1kq0A:
undetectable		 4g19D-1kq0A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MS4_A_2C0A501_1
(GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 1)		 1kq0 METHIONINE
AMINOPEPTIDASE 2
(Homo
sapiens) 		4 / 8 TRP A 419
SER A 381
ILE A 194
GLU A 201
 None
 1.27A 4ms4A-1kq0A:
undetectable		 4ms4A-1kq0A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_C_WJZC304_0
(BETA-LACTAMASE NDM-1)		 1kq0 METHIONINE
AMINOPEPTIDASE 2
(Homo
sapiens) 		4 / 7 MET A 184
HIS A 460
GLY A 475
HIS A 176
 TBU  A 501 ( 4.1A)
None
None
None
 1.30A 5a5zC-1kq0A:
undetectable		 5a5zC-1kq0A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_1
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		 1kq0 METHIONINE
AMINOPEPTIDASE 2
(Homo
sapiens) 		5 / 12 LEU A 447
PRO A 220
ASP A 262
ILE A 338
HIS A 331
 None
None
ZN  A 479 (-2.2A)
MED  A 601 ( 4.7A)
ZN  A 480 ( 3.4A)
 1.39A 5dv4A-1kq0A:
undetectable		 5dv4A-1kq0A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1O_H_DVAH9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 1kq0 METHIONINE
AMINOPEPTIDASE 2
(Homo
sapiens) 		3 / 3 ALA A 431
ASN A 434
LEU A 435
 None
 0.49A 5i1oA-1kq0A:
undetectable		 5i1oA-1kq0A:
6.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNW_D_GCSD302_1
(25 KDA PROTEIN
ELICITOR)		 1kq0 METHIONINE
AMINOPEPTIDASE 2
(Homo
sapiens) 		4 / 7 GLY A 330
HIS A 331
ASP A 262
HIS A 231
 None
ZN  A 480 ( 3.4A)
ZN  A 479 (-2.2A)
MED  A 601 (-4.2A)
 0.81A 5nnwD-1kq0A:
0.0		 5nnwD-1kq0A:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NO9_D_95ZD302_1
(25 KDA PROTEIN
ELICITOR)		 1kq0 METHIONINE
AMINOPEPTIDASE 2
(Homo
sapiens) 		4 / 7 GLY A 330
HIS A 331
ASP A 262
HIS A 231
 None
ZN  A 480 ( 3.4A)
ZN  A 479 (-2.2A)
MED  A 601 (-4.2A)
 0.82A 5no9D-1kq0A:
0.0		 5no9D-1kq0A:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T2Z_B_017B201_1
(PROTEASE)		 1kq0 METHIONINE
AMINOPEPTIDASE 2
(Homo
sapiens) 		5 / 12 ASP A 299
VAL A 344
GLY A 292
ILE A 293
SER A 332
 None
 1.07A 5t2zA-1kq0A:
undetectable		 5t2zA-1kq0A:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FK2_A_SORA302_0
(GALECTIN-3)		 1kq0 METHIONINE
AMINOPEPTIDASE 2
(Homo
sapiens) 		4 / 4 ARG A 465
GLU A 470
GLU A 163
ARG A 170
 None
 1.32A 6fk2A-1kq0A:
undetectable		 6fk2A-1kq0A:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 1kq0 METHIONINE
AMINOPEPTIDASE 2
(Homo
sapiens) 		4 / 8 GLY A 370
SER A 453
ASN A 327
VAL A 374
 None
 1.11A 6giqL-1kq0A:
0.0
6giqP-1kq0A:
0.0
6giqT-1kq0A:
0.0		 6giqL-1kq0A:
21.05
6giqP-1kq0A:
17.15
6giqT-1kq0A:
8.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 1kq0 METHIONINE
AMINOPEPTIDASE 2
(Homo
sapiens) 		5 / 9 ILE A 256
ALA A 215
GLY A 216
LEU A 217
GLY A 411
 None
 1.31A 6nm4B-1kq0A:
undetectable		 6nm4B-1kq0A:
17.29