SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1kqj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D8C_A_SORA4000_0
(MALATE SYNTHASE G)		 1kqj A/G-SPECIFIC ADENINE
GLYCOSYLASE
(Escherichia
coli) 		3 / 3 GLN A  94
HIS A  90
PRO A  69
 None
None
SO4  A 301 (-4.2A)
 0.96A 1d8cA-1kqjA:
undetectable		 1d8cA-1kqjA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBY_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1kqj A/G-SPECIFIC ADENINE
GLYCOSYLASE
(Escherichia
coli) 		5 / 12 ALA A  93
ALA A  92
GLN A  94
LEU A  65
ALA A  66
 None
 1.09A 1fbyA-1kqjA:
undetectable		 1fbyA-1kqjA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG2_A_ADNA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 1kqj A/G-SPECIFIC ADENINE
GLYCOSYLASE
(Escherichia
coli) 		5 / 12 GLY A 118
GLY A 116
THR A 121
ALA A 122
VAL A 111
 None
 1.19A 1jg2A-1kqjA:
undetectable		 1jg2A-1kqjA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC1383_1
(CES1 PROTEIN)		 1kqj A/G-SPECIFIC ADENINE
GLYCOSYLASE
(Escherichia
coli) 		4 / 5 TRP A  34
PRO A 105
LEU A 126
GLY A 123
 None
 1.10A 1ya4C-1kqjA:
undetectable		 1ya4C-1kqjA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 1kqj A/G-SPECIFIC ADENINE
GLYCOSYLASE
(Escherichia
coli) 		5 / 11 THR A 121
ILE A 125
GLY A 123
PHE A 108
GLY A 118
 None
 1.46A 2y7kA-1kqjA:
undetectable		 2y7kA-1kqjA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_B_SALB1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 1kqj A/G-SPECIFIC ADENINE
GLYCOSYLASE
(Escherichia
coli) 		5 / 10 THR A 121
ILE A 125
GLY A 123
PHE A 108
GLY A 118
 None
 1.40A 2y7wB-1kqjA:
undetectable		 2y7wB-1kqjA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA800_0
(GLUTAMATE RECEPTOR 2)		 1kqj A/G-SPECIFIC ADENINE
GLYCOSYLASE
(Escherichia
coli) 		4 / 7 TYR A  31
MET A  56
LEU A  65
ASP A  64
 GOL  A 303 (-4.3A)
None
None
None
 1.36A 3lslA-1kqjA:
undetectable
3lslD-1kqjA:
undetectable		 3lslA-1kqjA:
22.66
3lslD-1kqjA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_J_CLMJ221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1kqj A/G-SPECIFIC ADENINE
GLYCOSYLASE
(Escherichia
coli) 		5 / 12 PHE A 180
LEU A 204
VAL A 144
VAL A  10
CYH A 148
 None
SF4  A 300 ( 4.7A)
SF4  A 300 ( 4.4A)
None
None
 1.37A 3u9fJ-1kqjA:
undetectable
3u9fK-1kqjA:
undetectable		 3u9fJ-1kqjA:
22.48
3u9fK-1kqjA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JD6_A_TOYA501_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 1kqj A/G-SPECIFIC ADENINE
GLYCOSYLASE
(Escherichia
coli) 		5 / 9 PHE A 180
SER A 168
VAL A 171
TYR A 149
GLU A  37
 None
 1.04A 4jd6A-1kqjA:
0.0		 4jd6A-1kqjA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JD6_B_TOYB501_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 1kqj A/G-SPECIFIC ADENINE
GLYCOSYLASE
(Escherichia
coli) 		5 / 9 PHE A 180
SER A 168
VAL A 171
TYR A 149
GLU A  37
 None
 1.01A 4jd6B-1kqjA:
0.0		 4jd6B-1kqjA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLB_A_TRPA901_0
(PROTEIN ARGONAUTE-2)		 1kqj A/G-SPECIFIC ADENINE
GLYCOSYLASE
(Escherichia
coli) 		3 / 3 VAL A  73
ALA A  86
PHE A  55
 None
 0.89A 4olbA-1kqjA:
undetectable		 4olbA-1kqjA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_F_SC2F1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 1kqj A/G-SPECIFIC ADENINE
GLYCOSYLASE
(Escherichia
coli) 		3 / 3 VAL A 144
GLN A 205
CYH A 208
 SF4  A 300 ( 4.4A)
None
SF4  A 300 (-2.3A)
 0.83A 5icxC-1kqjA:
undetectable
5icxF-1kqjA:
undetectable		 5icxC-1kqjA:
19.01
5icxF-1kqjA:
6.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSU_B_SAMB1304_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 1kqj A/G-SPECIFIC ADENINE
GLYCOSYLASE
(Escherichia
coli) 		3 / 3 ASN A 213
TYR A 219
CYH A 208
 None
None
SF4  A 300 (-2.3A)
 0.90A 5lsuB-1kqjA:
undetectable		 5lsuB-1kqjA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 1kqj A/G-SPECIFIC ADENINE
GLYCOSYLASE
(Escherichia
coli) 		4 / 7 THR A  63
LEU A 114
GLN A  41
GLU A  37
 None
 1.13A 5tudA-1kqjA:
0.0		 5tudA-1kqjA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_A_7V7A201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 1kqj A/G-SPECIFIC ADENINE
GLYCOSYLASE
(Escherichia
coli) 		4 / 8 TRP A  77
THR A  78
TYR A  51
ARG A  58
 None
None
None
GOL  A 302 (-2.9A)
 1.36A 5tzoA-1kqjA:
undetectable		 5tzoA-1kqjA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 1kqj A/G-SPECIFIC ADENINE
GLYCOSYLASE
(Escherichia
coli) 		4 / 8 TRP A  77
THR A  78
TYR A  51
ARG A  58
 None
None
None
GOL  A 302 (-2.9A)
 1.35A 5tzoB-1kqjA:
undetectable		 5tzoB-1kqjA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_C_7V7C202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 1kqj A/G-SPECIFIC ADENINE
GLYCOSYLASE
(Escherichia
coli) 		4 / 8 TRP A  77
THR A  78
TYR A  51
ARG A  58
 None
None
None
GOL  A 302 (-2.9A)
 1.34A 5tzoC-1kqjA:
undetectable		 5tzoC-1kqjA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_A_9CRA503_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1kqj A/G-SPECIFIC ADENINE
GLYCOSYLASE
(Escherichia
coli) 		5 / 12 ALA A  93
ALA A  92
GLN A  94
LEU A  65
ALA A  66
 None
 0.87A 5uanA-1kqjA:
undetectable		 5uanA-1kqjA:
21.94