SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1kqo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1kqo NICOTINAMIDE
MONONUCLEOTIDE
ADENYLYL TRANSFERASE
(Homo
sapiens) 		3 / 3 THR A  95
LEU A  99
LEU A 106
 DND  A 301 (-3.9A)
None
None
 0.52A 1mz9C-1kqoA:
undetectable		 1mz9C-1kqoA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 1kqo NICOTINAMIDE
MONONUCLEOTIDE
ADENYLYL TRANSFERASE
(Homo
sapiens) 		5 / 12 ILE A 177
VAL A 178
HIS A 206
ALA A 164
VAL A 202
 None
 1.25A 2g72B-1kqoA:
2.3		 2g72B-1kqoA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_2
(PHOSPHOLIPASE A2)		 1kqo NICOTINAMIDE
MONONUCLEOTIDE
ADENYLYL TRANSFERASE
(Homo
sapiens) 		4 / 5 ILE A 226
SER A 223
PRO A  19
PHE A  17
 None
DND  A 301 ( 4.7A)
None
DND  A 301 (-4.6A)
 0.98A 3bjwC-1kqoA:
undetectable		 3bjwC-1kqoA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_1
(GLYCINE
N-METHYLTRANSFERASE)		 1kqo NICOTINAMIDE
MONONUCLEOTIDE
ADENYLYL TRANSFERASE
(Homo
sapiens) 		3 / 3 LEU A  27
HIS A  24
MET A  23
 DND  A 301 (-4.0A)
DND  A 301 ( 4.7A)
DND  A 301 (-3.2A)
 0.94A 3thrD-1kqoA:
undetectable		 3thrD-1kqoA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		 1kqo NICOTINAMIDE
MONONUCLEOTIDE
ADENYLYL TRANSFERASE
(Homo
sapiens) 		5 / 12 ASN A  22
ILE A 226
GLN A 234
ALA A 229
ILE A 236
 None
 0.99A 4uroC-1kqoA:
undetectable		 4uroC-1kqoA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZBD_B_TRPB501_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 1kqo NICOTINAMIDE
MONONUCLEOTIDE
ADENYLYL TRANSFERASE
(Homo
sapiens) 		5 / 10 ARG A  40
TYR A  34
ALA A  31
HIS A 211
VAL A   9
 None
 1.25A 5zbdB-1kqoA:
0.0		 5zbdB-1kqoA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_A_HISA402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 1kqo NICOTINAMIDE
MONONUCLEOTIDE
ADENYLYL TRANSFERASE
(Homo
sapiens) 		5 / 10 LEU A 159
THR A 187
CYH A 155
ALA A 193
LEU A 183
 DND  A 301 (-4.1A)
None
DND  A 301 (-4.7A)
None
None
 0.98A 6czmA-1kqoA:
0.2
6czmC-1kqoA:
undetectable		 6czmA-1kqoA:
22.37
6czmC-1kqoA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRX_A_H8GA1201_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 1kqo NICOTINAMIDE
MONONUCLEOTIDE
ADENYLYL TRANSFERASE
(Homo
sapiens) 		5 / 12 LEU A  11
VAL A  80
THR A  74
ALA A  73
PHE A  17
 None
None
None
None
DND  A 301 (-4.6A)
 1.46A 6drxA-1kqoA:
undetectable		 6drxA-1kqoA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G2P_A_TRPA502_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 1kqo NICOTINAMIDE
MONONUCLEOTIDE
ADENYLYL TRANSFERASE
(Homo
sapiens) 		5 / 7 ARG A  40
TYR A  34
HIS A 211
LEU A  11
VAL A   9
 None
 1.43A 6g2pA-1kqoA:
undetectable		 6g2pA-1kqoA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G2P_B_TRPB502_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 1kqo NICOTINAMIDE
MONONUCLEOTIDE
ADENYLYL TRANSFERASE
(Homo
sapiens) 		5 / 10 ARG A  40
TYR A  34
ALA A  31
HIS A 211
VAL A   9
 None
 1.32A 6g2pB-1kqoA:
0.5		 6g2pB-1kqoA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JMJ_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 1kqo NICOTINAMIDE
MONONUCLEOTIDE
ADENYLYL TRANSFERASE
(Homo
sapiens) 		4 / 5 GLY A  15
HIS A  24
SER A 222
SER A 223
 DND  A 301 (-3.4A)
DND  A 301 ( 4.7A)
None
DND  A 301 ( 4.7A)
 0.37A 6jmjA-1kqoA:
14.2		 6jmjA-1kqoA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JNH_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 1kqo NICOTINAMIDE
MONONUCLEOTIDE
ADENYLYL TRANSFERASE
(Homo
sapiens) 		5 / 7 GLY A  15
PHE A  17
HIS A  24
SER A 222
SER A 223
 DND  A 301 (-3.4A)
DND  A 301 (-4.6A)
DND  A 301 ( 4.7A)
None
DND  A 301 ( 4.7A)
 0.38A 6jnhA-1kqoA:
14.2		 6jnhA-1kqoA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JOG_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 1kqo NICOTINAMIDE
MONONUCLEOTIDE
ADENYLYL TRANSFERASE
(Homo
sapiens) 		4 / 6 GLY A  15
HIS A  24
SER A 222
SER A 223
 DND  A 301 (-3.4A)
DND  A 301 ( 4.7A)
None
DND  A 301 ( 4.7A)
 0.42A 6jogA-1kqoA:
14.2		 6jogA-1kqoA:
24.37