SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1kr1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 1kr1 HEVAMINE A
(Hevea
brasiliensis) 		5 / 10 TYR A 190
VAL A 230
ASN A 203
ILE A 236
LEU A 216
 None
 1.24A 1fe2A-1kr1A:
0.0		 1fe2A-1kr1A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGJ_D_DGXD228_1
(IGG2A-KAPPA 26-10
FAB (LIGHT CHAIN)
IGG2A-KAPPA 26-10
FAB (HEAVY CHAIN))		 1kr1 HEVAMINE A
(Hevea
brasiliensis) 		5 / 9 THR A  41
PRO A  42
ASN A 103
TYR A  99
SER A 111
 None
 1.33A 1igjC-1kr1A:
0.0
1igjD-1kr1A:
0.0		 1igjC-1kr1A:
21.16
1igjD-1kr1A:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1kr1 HEVAMINE A
(Hevea
brasiliensis) 		5 / 12 THR A 154
PHE A 175
LEU A 100
VAL A  96
PHE A  36
 None
 1.21A 1q23C-1kr1A:
0.0		 1q23C-1kr1A:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1kr1 HEVAMINE A
(Hevea
brasiliensis) 		5 / 11 THR A 154
PHE A 175
LEU A 100
VAL A  96
PHE A  36
 None
 1.24A 1q23L-1kr1A:
0.0		 1q23L-1kr1A:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1kr1 HEVAMINE A
(Hevea
brasiliensis) 		5 / 12 LEU A 137
LEU A  87
GLY A  79
ALA A 125
ALA A 156
 None
None
None
NAG  A 904 (-3.6A)
NAG  A 904 ( 4.2A)
 1.04A 2bm9A-1kr1A:
undetectable		 2bm9A-1kr1A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IYF_B_ERYB1399_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 1kr1 HEVAMINE A
(Hevea
brasiliensis) 		5 / 12 ASN A  29
TYR A  85
LEU A 170
ALA A 127
ASP A 176
 None
 1.33A 2iyfB-1kr1A:
2.2		 2iyfB-1kr1A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 1kr1 HEVAMINE A
(Hevea
brasiliensis) 		4 / 8 TRP A 101
ASP A 120
LEU A 119
GLY A 121
 None
 0.95A 2tsrB-1kr1A:
undetectable		 2tsrB-1kr1A:
22.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2UY4_A_AZMA1311_1
(ENDOCHITINASE)		 1kr1 HEVAMINE A
(Hevea
brasiliensis) 		6 / 9 TYR A   6
PHE A  32
GLY A  80
GLN A 181
TYR A 183
TRP A 255
 NAG  A 904 ( 4.2A)
NAG  A 904 (-4.3A)
NAG  A 904 (-3.7A)
NAG  A 904 (-3.2A)
NAG  A 904 (-4.6A)
NAG  A 904 ( 3.6A)
 0.38A 2uy4A-1kr1A:
36.9		 2uy4A-1kr1A:
36.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_G_ASDG1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1kr1 HEVAMINE A
(Hevea
brasiliensis) 		4 / 7 LEU A  78
LEU A 166
ALA A 169
PHE A 175
 None
 0.97A 2vcvG-1kr1A:
undetectable		 2vcvG-1kr1A:
21.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XTK_A_AZMA1339_1
(CLASS III CHITINASE
CHIA1)		 1kr1 HEVAMINE A
(Hevea
brasiliensis) 		5 / 11 TYR A   6
PHE A  32
GLY A  80
ALA A 224
TRP A 255
 NAG  A 904 ( 4.2A)
NAG  A 904 (-4.3A)
NAG  A 904 (-3.7A)
None
NAG  A 904 ( 3.6A)
 0.91A 2xtkA-1kr1A:
36.0		 2xtkA-1kr1A:
31.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XTK_A_AZMA1339_1
(CLASS III CHITINASE
CHIA1)		 1kr1 HEVAMINE A
(Hevea
brasiliensis) 		8 / 11 TYR A   6
PHE A  32
GLY A  80
GLN A 181
TYR A 183
ASN A 184
ALA A 225
TRP A 255
 NAG  A 904 ( 4.2A)
NAG  A 904 (-4.3A)
NAG  A 904 (-3.7A)
NAG  A 904 (-3.2A)
NAG  A 904 (-4.6A)
NAG  A 904 (-3.7A)
NAG  A 904 (-3.7A)
NAG  A 904 ( 3.6A)
 0.54A 2xtkA-1kr1A:
36.0		 2xtkA-1kr1A:
31.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XTK_B_AZMB1339_1
(CLASS III CHITINASE
CHIA1)		 1kr1 HEVAMINE A
(Hevea
brasiliensis) 		6 / 10 TYR A   6
PHE A  32
GLY A  80
GLN A 181
TYR A 183
TRP A 255
 NAG  A 904 ( 4.2A)
NAG  A 904 (-4.3A)
NAG  A 904 (-3.7A)
NAG  A 904 (-3.2A)
NAG  A 904 (-4.6A)
NAG  A 904 ( 3.6A)
 0.38A 2xtkB-1kr1A:
36.3		 2xtkB-1kr1A:
31.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_B_VD3B2001_1
(VITAMIN D
HYDROXYLASE)		 1kr1 HEVAMINE A
(Hevea
brasiliensis) 		5 / 11 ILE A  44
LEU A  16
ASN A  62
LEU A  76
ILE A  30
 None
SO4  A 801 (-4.5A)
None
None
None
 1.40A 3a50B-1kr1A:
undetectable		 3a50B-1kr1A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_E_CLME221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1kr1 HEVAMINE A
(Hevea
brasiliensis) 		5 / 10 THR A 154
PHE A 175
LEU A 100
VAL A  96
PHE A  36
 None
 1.28A 3u9fE-1kr1A:
0.0		 3u9fE-1kr1A:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_I_CLMI221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1kr1 HEVAMINE A
(Hevea
brasiliensis) 		5 / 10 THR A 154
PHE A 175
LEU A 100
VAL A  96
PHE A  36
 None
 1.35A 3u9fI-1kr1A:
0.0		 3u9fI-1kr1A:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_K_CLMK221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1kr1 HEVAMINE A
(Hevea
brasiliensis) 		5 / 10 THR A 154
PHE A 175
LEU A 100
VAL A  96
PHE A  36
 None
 1.23A 3u9fK-1kr1A:
0.0		 3u9fK-1kr1A:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_L_CLML221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1kr1 HEVAMINE A
(Hevea
brasiliensis) 		5 / 12 THR A 154
PHE A 175
LEU A 100
VAL A  96
PHE A  36
 None
 1.32A 3u9fJ-1kr1A:
undetectable
3u9fL-1kr1A:
0.0		 3u9fJ-1kr1A:
18.51
3u9fL-1kr1A:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_N_CLMN221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1kr1 HEVAMINE A
(Hevea
brasiliensis) 		5 / 11 THR A 154
PHE A 175
LEU A 100
VAL A  96
PHE A  36
 None
 1.34A 3u9fN-1kr1A:
0.0
3u9fO-1kr1A:
0.0		 3u9fN-1kr1A:
18.51
3u9fO-1kr1A:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_P_CLMP221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1kr1 HEVAMINE A
(Hevea
brasiliensis) 		5 / 9 THR A 154
PHE A 175
LEU A 100
VAL A  96
PHE A  36
 None
 1.36A 3u9fP-1kr1A:
0.0		 3u9fP-1kr1A:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_S_CLMS221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1kr1 HEVAMINE A
(Hevea
brasiliensis) 		5 / 12 THR A 154
PHE A 175
LEU A 100
VAL A  96
PHE A  36
 None
 1.27A 3u9fP-1kr1A:
0.0
3u9fS-1kr1A:
0.0		 3u9fP-1kr1A:
18.51
3u9fS-1kr1A:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRJ_A_1KXA301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN
10-MER PEPTIDE)		 1kr1 HEVAMINE A
(Hevea
brasiliensis) 		5 / 12 ILE A  30
VAL A  28
TYR A  25
THR A  22
ILE A  64
 None
 1.16A 3vrjA-1kr1A:
undetectable
3vrjC-1kr1A:
undetectable		 3vrjA-1kr1A:
19.81
3vrjC-1kr1A:
5.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_A_NCAA1201_0
(TANKYRASE-2)		 1kr1 HEVAMINE A
(Hevea
brasiliensis) 		4 / 7 GLY A 228
ALA A 224
TYR A 229
GLU A 223
 None
 0.91A 4hyfA-1kr1A:
undetectable		 4hyfA-1kr1A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_B_NCAB1201_0
(TANKYRASE-2)		 1kr1 HEVAMINE A
(Hevea
brasiliensis) 		4 / 8 GLY A 228
ALA A 224
TYR A 229
GLU A 223
 None
 0.90A 4hyfB-1kr1A:
undetectable		 4hyfB-1kr1A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_C_NCAC1201_0
(TANKYRASE-2)		 1kr1 HEVAMINE A
(Hevea
brasiliensis) 		4 / 8 GLY A 228
ALA A 224
TYR A 229
GLU A 223
 None
 0.90A 4hyfC-1kr1A:
undetectable		 4hyfC-1kr1A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PST_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1kr1 HEVAMINE A
(Hevea
brasiliensis) 		3 / 3 ILE A  64
ASP A 120
ARG A 112
 None
 0.80A 4pstA-1kr1A:
undetectable		 4pstA-1kr1A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_B_HFGB703_0
(AMINOACYL-TRNA
SYNTHETASE)		 1kr1 HEVAMINE A
(Hevea
brasiliensis) 		5 / 12 LEU A 170
PHE A 175
VAL A 178
PRO A 157
GLY A  81
 None
None
None
None
NAG  A 903 ( 3.5A)
 1.11A 5f9zB-1kr1A:
undetectable		 5f9zB-1kr1A:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA603_1
(CHITINASE)		 1kr1 HEVAMINE A
(Hevea
brasiliensis) 		4 / 8 GLY A   8
GLU A  13
TYR A 259
TRP A 255
 None
None
NAG  A 903 (-4.7A)
NAG  A 904 ( 3.6A)
 0.95A 5gqbA-1kr1A:
10.2		 5gqbA-1kr1A:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA603_1
(CHITINASE)		 1kr1 HEVAMINE A
(Hevea
brasiliensis) 		4 / 8 PHE A  32
GLY A  80
TYR A 183
TRP A 255
 NAG  A 904 (-4.3A)
NAG  A 904 (-3.7A)
NAG  A 904 (-4.6A)
NAG  A 904 ( 3.6A)
 0.42A 5gqbA-1kr1A:
10.2		 5gqbA-1kr1A:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GSN_A_MMZA503_1
(FLAVIN-CONTAINING
MONOOXYGENASE)		 1kr1 HEVAMINE A
(Hevea
brasiliensis) 		3 / 3 ASN A 103
SER A 111
SER A 110
 None
 0.66A 5gsnA-1kr1A:
0.0		 5gsnA-1kr1A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_A_ACTA708_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 1kr1 HEVAMINE A
(Hevea
brasiliensis) 		3 / 3 GLY A 107
GLY A 106
GLN A 147
 None
 0.46A 5imsA-1kr1A:
undetectable		 5imsA-1kr1A:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_E_SAME501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1kr1 HEVAMINE A
(Hevea
brasiliensis) 		5 / 9 LEU A  33
PRO A  42
GLY A  79
VAL A  96
LEU A 100
 None
 1.49A 5o96E-1kr1A:
0.0
5o96F-1kr1A:
0.0		 5o96E-1kr1A:
23.18
5o96F-1kr1A:
23.18