SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ks5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB6_0
(GRAMICIDIN A)		 1ks5 ENDOGLUCANASE A
(Aspergillus
niger) 		3 / 3 TRP A  51
ALA A  94
VAL A  58
 None
 0.99A 1bdwA-1ks5A:
undetectable
1bdwB-1ks5A:
undetectable		 1bdwA-1ks5A:
8.53
1bdwB-1ks5A:
8.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 1ks5 ENDOGLUCANASE A
(Aspergillus
niger) 		5 / 12 PHE A  68
VAL A  66
PHE A 163
ILE A 119
LEU A 196
 None
 1.06A 2ft9A-1ks5A:
undetectable		 2ft9A-1ks5A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1ks5 ENDOGLUCANASE A
(Aspergillus
niger) 		5 / 12 ALA A  97
LEU A 117
THR A  81
ILE A  79
LEU A 196
 None
 1.12A 2oipA-1ks5A:
undetectable		 2oipA-1ks5A:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_D_MTXD617_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1ks5 ENDOGLUCANASE A
(Aspergillus
niger) 		5 / 12 ALA A  97
LEU A 117
THR A  81
ILE A  79
LEU A 196
 None
 1.03A 2oipD-1ks5A:
undetectable		 2oipD-1ks5A:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_E_MTXE621_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1ks5 ENDOGLUCANASE A
(Aspergillus
niger) 		5 / 12 ALA A  97
LEU A 117
THR A  81
ILE A  79
LEU A 196
 None
 0.93A 2oipE-1ks5A:
undetectable		 2oipE-1ks5A:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XPW_A_OTCA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 1ks5 ENDOGLUCANASE A
(Aspergillus
niger) 		5 / 12 LEU A  38
SER A  64
ASN A  18
PRO A  14
VAL A  66
 None
 1.47A 2xpwA-1ks5A:
undetectable		 2xpwA-1ks5A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1ks5 ENDOGLUCANASE A
(Aspergillus
niger) 		5 / 12 ALA A  97
LEU A 117
THR A  81
ILE A  79
LEU A 196
 None
 1.17A 3hj3A-1ks5A:
undetectable		 3hj3A-1ks5A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1ks5 ENDOGLUCANASE A
(Aspergillus
niger) 		5 / 12 ALA A  97
LEU A 117
THR A  81
ILE A  79
LEU A 196
 None
 1.10A 3hj3B-1ks5A:
undetectable		 3hj3B-1ks5A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_D_MTXD615_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1ks5 ENDOGLUCANASE A
(Aspergillus
niger) 		5 / 12 ALA A  97
LEU A 117
THR A  81
ILE A  79
LEU A 196
 None
 0.88A 3hj3D-1ks5A:
undetectable		 3hj3D-1ks5A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB504_1
(HEMOLYTIC LECTIN
CEL-III)		 1ks5 ENDOGLUCANASE A
(Aspergillus
niger) 		4 / 5 GLU A 116
GLY A 113
TYR A 115
GLN A 194
 None
 1.44A 3w9tB-1ks5A:
0.0		 3w9tB-1ks5A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD506_1
(HEMOLYTIC LECTIN
CEL-III)		 1ks5 ENDOGLUCANASE A
(Aspergillus
niger) 		4 / 5 GLU A 116
GLY A 113
TYR A 115
GLN A 194
 None
 1.40A 3w9tD-1ks5A:
undetectable		 3w9tD-1ks5A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRI_A_RAPA201_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5
SERINE/THREONINE-PRO
TEIN KINASE MTOR)		 1ks5 ENDOGLUCANASE A
(Aspergillus
niger) 		5 / 10 LEU A 121
SER A 165
ARG A 123
THR A 138
TRP A 144
 None
 1.32A 4driB-1ks5A:
undetectable		 4driB-1ks5A:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRJ_A_RAPA201_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
SERINE/THREONINE-PRO
TEIN KINASE MTOR)		 1ks5 ENDOGLUCANASE A
(Aspergillus
niger) 		4 / 8 LEU A 121
SER A 165
THR A 138
TRP A 144
 None
 1.10A 4drjB-1ks5A:
undetectable		 4drjB-1ks5A:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDA_A_DEXA1985_2
(MINERALOCORTICOID
RECEPTOR)		 1ks5 ENDOGLUCANASE A
(Aspergillus
niger) 		4 / 6 TRP A 144
LEU A 100
THR A  81
VAL A  83
 None
 1.10A 4udaA-1ks5A:
undetectable		 4udaA-1ks5A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP1_A_LDPA708_1
(DOPAMINE
TRANSPORTER, ISOFORM
B)		 1ks5 ENDOGLUCANASE A
(Aspergillus
niger) 		5 / 10 ALA A  97
VAL A  96
ASP A  95
PHE A 201
SER A  62
 None
 1.20A 4xp1A-1ks5A:
undetectable		 4xp1A-1ks5A:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_A_7V7A201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 1ks5 ENDOGLUCANASE A
(Aspergillus
niger) 		4 / 8 TRP A  45
THR A 203
TYR A  61
GLN A  19
 None
 1.02A 5tzoA-1ks5A:
16.6		 5tzoA-1ks5A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 1ks5 ENDOGLUCANASE A
(Aspergillus
niger) 		4 / 8 TRP A  45
THR A 203
TYR A  61
GLN A  19
 None
 1.11A 5tzoB-1ks5A:
16.5		 5tzoB-1ks5A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_C_7V7C202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 1ks5 ENDOGLUCANASE A
(Aspergillus
niger) 		4 / 8 TRP A  45
THR A 203
TYR A  61
GLN A  19
 None
 1.05A 5tzoC-1ks5A:
16.5		 5tzoC-1ks5A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECE_C_DVAC3010_0
(VLM2
DODECADEPSIPEPTIDE)		 1ks5 ENDOGLUCANASE A
(Aspergillus
niger) 		3 / 3 ALA A 109
PHE A 101
GLN A 158
 None
 0.80A 6eceA-1ks5A:
undetectable		 6eceA-1ks5A:
18.64