SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ks9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_D_LYAD315_1
(THYMIDYLATE SYNTHASE)		 1ks9 2-DEHYDROPANTOATE
2-REDUCTASE
(Escherichia
coli) 		5 / 11 ILE A  96
ASN A  98
LEU A  14
GLY A  12
ALA A 121
 None
 1.29A 1ju6D-1ks9A:
0.0		 1ju6D-1ks9A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_B_RBFB101_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 1ks9 2-DEHYDROPANTOATE
2-REDUCTASE
(Escherichia
coli) 		5 / 11 VAL A  69
SER A  85
LEU A  87
THR A  86
THR A   4
 None
 1.29A 1pkvA-1ks9A:
undetectable
1pkvB-1ks9A:
undetectable		 1pkvA-1ks9A:
16.72
1pkvB-1ks9A:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_A_DESA459_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 1ks9 2-DEHYDROPANTOATE
2-REDUCTASE
(Escherichia
coli) 		5 / 12 LEU A  68
MET A   1
VAL A 159
LEU A 152
ILE A  93
 None
 1.13A 1s9pA-1ks9A:
undetectable		 1s9pA-1ks9A:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_D_DESD600_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 1ks9 2-DEHYDROPANTOATE
2-REDUCTASE
(Escherichia
coli) 		5 / 12 LEU A  68
MET A   1
VAL A 159
LEU A 152
ILE A  93
 None
 1.08A 1s9pD-1ks9A:
undetectable		 1s9pD-1ks9A:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUV_A_VK3A4558_1
(PROTEIN YGIN)		 1ks9 2-DEHYDROPANTOATE
2-REDUCTASE
(Escherichia
coli) 		4 / 7 LEU A 156
TYR A 151
MET A   1
ILE A   3
 None
 0.88A 1tuvA-1ks9A:
undetectable		 1tuvA-1ks9A:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_H_TOPH200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 1ks9 2-DEHYDROPANTOATE
2-REDUCTASE
(Escherichia
coli) 		5 / 9 ALA A  79
LEU A  67
VAL A  69
ILE A 109
LEU A 113
 None
 1.31A 3fl9H-1ks9A:
undetectable		 3fl9H-1ks9A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FW3_B_ETSB303_1
(CARBONIC ANHYDRASE 4)		 1ks9 2-DEHYDROPANTOATE
2-REDUCTASE
(Escherichia
coli) 		5 / 12 HIS A  97
VAL A  69
ILE A  93
LEU A 106
THR A 102
 None
 1.07A 3fw3B-1ks9A:
0.0		 3fw3B-1ks9A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_B_MRVB1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 1ks9 2-DEHYDROPANTOATE
2-REDUCTASE
(Escherichia
coli) 		4 / 5 TYR A 259
THR A   4
LEU A  67
MET A 115
 None
 1.31A 4mbsB-1ks9A:
0.0		 4mbsB-1ks9A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_B_RBFB201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1ks9 2-DEHYDROPANTOATE
2-REDUCTASE
(Escherichia
coli) 		4 / 8 THR A  70
ILE A 139
LEU A  16
LEU A 160
 None
 0.94A 4r38B-1ks9A:
undetectable		 4r38B-1ks9A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_C_RBVC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1ks9 2-DEHYDROPANTOATE
2-REDUCTASE
(Escherichia
coli) 		3 / 3 THR A 102
HIS A 120
LEU A  11
 None
 0.85A 5axdC-1ks9A:
7.9		 5axdC-1ks9A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESG_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1ks9 2-DEHYDROPANTOATE
2-REDUCTASE
(Escherichia
coli) 		4 / 4 LEU A  95
TYR A 151
PRO A 141
ILE A 169
 None
 1.26A 5esgA-1ks9A:
1.3		 5esgA-1ks9A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_A_C2FA402_0
(THYMIDYLATE SYNTHASE)		 1ks9 2-DEHYDROPANTOATE
2-REDUCTASE
(Escherichia
coli) 		5 / 11 ILE A 129
LEU A  53
LEU A  14
GLY A  12
ALA A  18
 None
 1.29A 5fctA-1ks9A:
0.0		 5fctA-1ks9A:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_2
(ENVELOPE
GLYCOPROTEIN 2)		 1ks9 2-DEHYDROPANTOATE
2-REDUCTASE
(Escherichia
coli) 		4 / 7 LEU A  68
THR A 118
THR A 119
LEU A  19
 None
 1.11A 5jq7B-1ks9A:
undetectable		 5jq7B-1ks9A:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_A_ACTA204_0
(N-ACETYLTRANSFERASE)		 1ks9 2-DEHYDROPANTOATE
2-REDUCTASE
(Escherichia
coli) 		4 / 5 LEU A  61
THR A   4
THR A  54
GLY A  28
 None
 1.29A 6gtqA-1ks9A:
0.7		 6gtqA-1ks9A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_F_FFOF403_0
(THYMIDYLATE SYNTHASE)		 1ks9 2-DEHYDROPANTOATE
2-REDUCTASE
(Escherichia
coli) 		5 / 11 ILE A 129
LEU A  53
LEU A  14
GLY A  12
ALA A  18
 None
 1.25A 6r2eF-1ks9A:
0.0		 6r2eF-1ks9A:
21.97