SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ksh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LS4_H_TCIH220_1
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT)		 1ksh ARF-LIKE PROTEIN 2
(Mus
musculus) 		5 / 10 LEU A 109
TYR A  76
GLY A  69
VAL A  67
GLY A  23
 None
None
PO4  A 203 (-3.7A)
None
None
 1.29A 3ls4H-1kshA:
undetectable		 3ls4H-1kshA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_A_AICA375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 1ksh ARF-LIKE PROTEIN 2
(Mus
musculus) 		5 / 11 GLY A  86
LEU A  62
ASN A  63
LEU A 173
LEU A 172
 None
 1.40A 3ndvA-1kshA:
0.0
3ndvB-1kshA:
0.0		 3ndvA-1kshA:
19.26
3ndvB-1kshA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_A_SUEA1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 1ksh ARF-LIKE PROTEIN 2
(Mus
musculus) 		4 / 4 PHE A  50
TYR A  76
ILE A  88
LEU A  19
 None
 1.26A 3sudA-1kshA:
undetectable		 3sudA-1kshA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 1ksh ARF-LIKE PROTEIN 2
(Mus
musculus) 		4 / 5 PHE A  50
TYR A  76
ILE A  88
LEU A  19
 None
 1.27A 3sueC-1kshA:
undetectable		 3sueC-1kshA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_D_RBFD201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1ksh ARF-LIKE PROTEIN 2
(Mus
musculus) 		4 / 8 LEU A  33
LEU A 172
ILE A  88
PHE A  60
 None
 0.88A 4r38D-1kshA:
undetectable		 4r38D-1kshA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE0_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1ksh ARF-LIKE PROTEIN 2
(Mus
musculus) 		5 / 9 PHE A 123
ILE A  32
GLY A 168
LEU A 173
LEU A  62
 None
 1.34A 4ze0A-1kshA:
undetectable		 4ze0A-1kshA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YVN_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 1ksh ARF-LIKE PROTEIN 2
(Mus
musculus) 		4 / 6 LEU A 110
GLN A 107
LEU A 142
LEU A 144
 None
 1.16A 5yvnA-1kshA:
undetectable		 5yvnA-1kshA:
22.63