SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ksk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG7_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 1ksk RIBOSOMAL SMALL
SUBUNIT
PSEUDOURIDINE
SYNTHASE A
(Escherichia
coli) 		3 / 3 ILE A 205
ILE A 208
THR A 122
 None
 0.61A 1rg7A-1kskA:
undetectable		 1rg7A-1kskA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GEH_A_NHYA300_1
(CARBONIC ANHYDRASE 2)		 1ksk RIBOSOMAL SMALL
SUBUNIT
PSEUDOURIDINE
SYNTHASE A
(Escherichia
coli) 		4 / 8 HIS A  45
VAL A  47
VAL A  29
LEU A   3
 None
 0.73A 2gehA-1kskA:
undetectable		 2gehA-1kskA:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_C_TRPC1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1ksk RIBOSOMAL SMALL
SUBUNIT
PSEUDOURIDINE
SYNTHASE A
(Escherichia
coli) 		5 / 10 GLN A   9
ASP A   4
ILE A  22
VAL A  27
VAL A  47
 None
 1.40A 3fhjC-1kskA:
undetectable		 3fhjC-1kskA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_E_TRPE1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1ksk RIBOSOMAL SMALL
SUBUNIT
PSEUDOURIDINE
SYNTHASE A
(Escherichia
coli) 		5 / 10 GLN A   9
ASP A   4
ILE A  22
VAL A  27
VAL A  47
 None
 1.38A 3fhjE-1kskA:
undetectable		 3fhjE-1kskA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_C_TRPC1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1ksk RIBOSOMAL SMALL
SUBUNIT
PSEUDOURIDINE
SYNTHASE A
(Escherichia
coli) 		5 / 9 GLN A   9
ASP A   4
ILE A  22
VAL A  27
VAL A  47
 None
 1.45A 3fi0C-1kskA:
undetectable		 3fi0C-1kskA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_H_TRPH1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1ksk RIBOSOMAL SMALL
SUBUNIT
PSEUDOURIDINE
SYNTHASE A
(Escherichia
coli) 		5 / 9 GLN A   9
ASP A   4
ILE A  22
VAL A  27
VAL A  47
 None
 1.41A 3fi0H-1kskA:
undetectable		 3fi0H-1kskA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_J_TRPJ1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1ksk RIBOSOMAL SMALL
SUBUNIT
PSEUDOURIDINE
SYNTHASE A
(Escherichia
coli) 		5 / 9 GLN A   9
ASP A   4
ILE A  22
VAL A  27
VAL A  47
 None
 1.49A 3fi0J-1kskA:
0.0		 3fi0J-1kskA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_L_TRPL1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1ksk RIBOSOMAL SMALL
SUBUNIT
PSEUDOURIDINE
SYNTHASE A
(Escherichia
coli) 		5 / 9 GLN A   9
ASP A   4
ILE A  22
VAL A  27
VAL A  47
 None
 1.41A 3fi0L-1kskA:
undetectable		 3fi0L-1kskA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_N_TRPN1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1ksk RIBOSOMAL SMALL
SUBUNIT
PSEUDOURIDINE
SYNTHASE A
(Escherichia
coli) 		5 / 9 GLN A   9
ASP A   4
ILE A  22
VAL A  27
VAL A  47
 None
 1.44A 3fi0N-1kskA:
undetectable		 3fi0N-1kskA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_O_TRPO1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1ksk RIBOSOMAL SMALL
SUBUNIT
PSEUDOURIDINE
SYNTHASE A
(Escherichia
coli) 		5 / 9 GLN A   9
ASP A   4
ILE A  22
VAL A  27
VAL A  47
 None
 1.45A 3fi0O-1kskA:
undetectable		 3fi0O-1kskA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_R_TRPR1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1ksk RIBOSOMAL SMALL
SUBUNIT
PSEUDOURIDINE
SYNTHASE A
(Escherichia
coli) 		5 / 9 GLN A   9
ASP A   4
ILE A  22
VAL A  27
VAL A  47
 None
 1.41A 3fi0R-1kskA:
undetectable		 3fi0R-1kskA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HYR_A_ESTA601_1
(ESTROGEN RECEPTOR)		 1ksk RIBOSOMAL SMALL
SUBUNIT
PSEUDOURIDINE
SYNTHASE A
(Escherichia
coli) 		5 / 10 LEU A  65
ALA A  97
LEU A 101
ARG A 202
LEU A  84
 None
None
URA  A 232 ( 4.4A)
None
None
 1.50A 5hyrA-1kskA:
undetectable		 5hyrA-1kskA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_F_EZLF302_1
(ALPHA-CARBONIC
ANHYDRASE)		 1ksk RIBOSOMAL SMALL
SUBUNIT
PSEUDOURIDINE
SYNTHASE A
(Escherichia
coli) 		4 / 8 HIS A  45
VAL A  47
VAL A  29
LEU A   3
 None
 0.84A 5tt3F-1kskA:
undetectable		 5tt3F-1kskA:
20.00