SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1kt8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_B_ACTB704_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ARG A 285
GLY A 252
ASP A 251
 None
 0.59A 1kf6A-1kt8A:
undetectable
1kf6B-1kt8A:
undetectable		 1kf6A-1kt8A:
20.75
1kf6B-1kt8A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LH6_A_NIOA155_1
(LEGHEMOGLOBIN A
(NICOTINATE MET))		 1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 PHE A 284
PHE A 345
PHE A 309
VAL A 286
 None
 0.99A 1lh6A-1kt8A:
undetectable		 1lh6A-1kt8A:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_W_CHDW4060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 ILE A 332
MET A 293
THR A 292
LEU A 235
 None
 0.79A 1v54N-1kt8A:
0.0
1v54W-1kt8A:
0.0		 1v54N-1kt8A:
22.71
1v54W-1kt8A:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_J_CHDJ3060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 ILE A 332
MET A 293
THR A 292
LEU A 235
 None
 0.78A 1v55A-1kt8A:
undetectable
1v55J-1kt8A:
0.0		 1v55A-1kt8A:
22.71
1v55J-1kt8A:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_W_CHDW4060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 ILE A 332
MET A 293
THR A 292
LEU A 235
 None
 0.79A 1v55N-1kt8A:
0.0
1v55W-1kt8A:
undetectable		 1v55N-1kt8A:
22.71
1v55W-1kt8A:
12.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A1H_A_GBNA502_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 8 TYR A 141
ARG A 143
GLY A 312
THR A 313
ALA A 314
 ILP  A 400 (-4.5A)
None
ILP  A 400 (-3.5A)
ILP  A 400 (-3.6A)
ILP  A 400 ( 4.7A)
 0.14A 2a1hA-1kt8A:
55.9
2a1hB-1kt8A:
55.9		 2a1hA-1kt8A:
100.00
2a1hB-1kt8A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A1H_A_GBNA502_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 TYR A 141
ARG A 143
THR A 240
GLY A 312
 ILP  A 400 (-4.5A)
None
ILP  A 400 (-3.9A)
ILP  A 400 (-3.5A)
 0.61A 2a1hA-1kt8A:
55.9
2a1hB-1kt8A:
55.9		 2a1hA-1kt8A:
100.00
2a1hB-1kt8A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A1H_B_GBNB501_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 8 TYR A 141
ARG A 143
GLY A 312
THR A 313
ALA A 314
 ILP  A 400 (-4.5A)
None
ILP  A 400 (-3.5A)
ILP  A 400 (-3.6A)
ILP  A 400 ( 4.7A)
 0.15A 2a1hA-1kt8A:
55.9
2a1hB-1kt8A:
55.9		 2a1hA-1kt8A:
100.00
2a1hB-1kt8A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A1H_B_GBNB501_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 8 TYR A 141
ARG A 143
THR A 240
GLY A 312
THR A 313
 ILP  A 400 (-4.5A)
None
ILP  A 400 (-3.9A)
ILP  A 400 (-3.5A)
ILP  A 400 (-3.6A)
 0.64A 2a1hA-1kt8A:
55.9
2a1hB-1kt8A:
55.9		 2a1hA-1kt8A:
100.00
2a1hB-1kt8A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A7Q_A_CFBA328_2
(DEOXYCYTIDINE KINASE)		 1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 4 ILE A  53
ASP A 130
LEU A 140
ARG A 123
 None
 1.23A 2a7qA-1kt8A:
undetectable		 2a7qA-1kt8A:
20.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2COI_A_GBNA420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		6 / 10 TYR A 141
ARG A 143
MET A 241
GLY A 312
THR A 313
ALA A 314
 ILP  A 400 (-4.5A)
None
None
ILP  A 400 (-3.5A)
ILP  A 400 (-3.6A)
ILP  A 400 ( 4.7A)
 0.34A 2coiA-1kt8A:
53.0
2coiB-1kt8A:
52.8		 2coiA-1kt8A:
55.96
2coiB-1kt8A:
55.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2COI_A_GBNA420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		6 / 10 TYR A 141
ARG A 143
THR A 240
MET A 241
GLY A 312
THR A 313
 ILP  A 400 (-4.5A)
None
ILP  A 400 (-3.9A)
None
ILP  A 400 (-3.5A)
ILP  A 400 (-3.6A)
 0.77A 2coiA-1kt8A:
53.0
2coiB-1kt8A:
52.8		 2coiA-1kt8A:
55.96
2coiB-1kt8A:
55.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2COI_A_GBNA420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 TYR A 173
MET A 241
GLY A 312
THR A 313
ALA A 314
 None
None
ILP  A 400 (-3.5A)
ILP  A 400 (-3.6A)
ILP  A 400 ( 4.7A)
 1.18A 2coiA-1kt8A:
53.0
2coiB-1kt8A:
52.8		 2coiA-1kt8A:
55.96
2coiB-1kt8A:
55.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2COI_A_GBNA420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 TYR A 173
THR A 240
MET A 241
GLY A 312
THR A 313
 None
ILP  A 400 (-3.9A)
None
ILP  A 400 (-3.5A)
ILP  A 400 (-3.6A)
 1.18A 2coiA-1kt8A:
53.0
2coiB-1kt8A:
52.8		 2coiA-1kt8A:
55.96
2coiB-1kt8A:
55.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2COI_B_GBNB420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		6 / 10 TYR A 141
ARG A 143
MET A 241
GLY A 312
THR A 313
ALA A 314
 ILP  A 400 (-4.5A)
None
None
ILP  A 400 (-3.5A)
ILP  A 400 (-3.6A)
ILP  A 400 ( 4.7A)
 0.42A 2coiA-1kt8A:
53.0
2coiB-1kt8A:
52.8		 2coiA-1kt8A:
55.96
2coiB-1kt8A:
55.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2COI_B_GBNB420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		6 / 10 TYR A 141
ARG A 143
THR A 240
MET A 241
GLY A 312
THR A 313
 ILP  A 400 (-4.5A)
None
ILP  A 400 (-3.9A)
None
ILP  A 400 (-3.5A)
ILP  A 400 (-3.6A)
 0.77A 2coiA-1kt8A:
53.0
2coiB-1kt8A:
52.8		 2coiA-1kt8A:
55.96
2coiB-1kt8A:
55.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2COJ_A_GBNA420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		7 / 11 PHE A  75
TYR A 141
ARG A 143
MET A 241
GLY A 312
THR A 313
ALA A 314
 None
ILP  A 400 (-4.5A)
None
None
ILP  A 400 (-3.5A)
ILP  A 400 (-3.6A)
ILP  A 400 ( 4.7A)
 0.42A 2cojA-1kt8A:
52.9
2cojB-1kt8A:
52.4		 2cojA-1kt8A:
55.96
2cojB-1kt8A:
55.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2COJ_A_GBNA420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		7 / 11 PHE A  75
TYR A 141
ARG A 143
THR A 240
MET A 241
GLY A 312
THR A 313
 None
ILP  A 400 (-4.5A)
None
ILP  A 400 (-3.9A)
None
ILP  A 400 (-3.5A)
ILP  A 400 (-3.6A)
 0.74A 2cojA-1kt8A:
52.9
2cojB-1kt8A:
52.4		 2cojA-1kt8A:
55.96
2cojB-1kt8A:
55.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2COJ_B_GBNB420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		6 / 9 TYR A 141
ARG A 143
MET A 241
GLY A 312
THR A 313
ALA A 314
 ILP  A 400 (-4.5A)
None
None
ILP  A 400 (-3.5A)
ILP  A 400 (-3.6A)
ILP  A 400 ( 4.7A)
 0.47A 2cojA-1kt8A:
52.9
2cojB-1kt8A:
52.4		 2cojA-1kt8A:
55.96
2cojB-1kt8A:
55.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2COJ_B_GBNB420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 9 TYR A 141
ARG A 143
THR A 240
MET A 241
GLY A 312
 ILP  A 400 (-4.5A)
None
ILP  A 400 (-3.9A)
None
ILP  A 400 (-3.5A)
 0.82A 2cojA-1kt8A:
52.9
2cojB-1kt8A:
52.4		 2cojA-1kt8A:
55.96
2cojB-1kt8A:
55.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 ILE A 332
MET A 293
THR A 292
LEU A 235
 None
 0.80A 2dyrN-1kt8A:
0.0
2dyrW-1kt8A:
0.0		 2dyrN-1kt8A:
22.71
2dyrW-1kt8A:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 ILE A 332
MET A 293
THR A 292
LEU A 235
 None
 0.79A 2eijN-1kt8A:
0.0
2eijW-1kt8A:
undetectable		 2eijN-1kt8A:
22.71
2eijW-1kt8A:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 ILE A 332
MET A 293
THR A 292
LEU A 235
 None
 0.77A 2eikN-1kt8A:
0.0
2eikW-1kt8A:
0.0		 2eikN-1kt8A:
22.71
2eikW-1kt8A:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 ILE A 332
MET A 293
THR A 292
LEU A 235
 None
 0.78A 2eilN-1kt8A:
0.0
2eilW-1kt8A:
0.0		 2eilN-1kt8A:
22.71
2eilW-1kt8A:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 ILE A 332
MET A 293
THR A 292
LEU A 235
 None
 0.74A 2einA-1kt8A:
0.0
2einJ-1kt8A:
undetectable		 2einA-1kt8A:
22.71
2einJ-1kt8A:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 ILE A 332
MET A 293
THR A 292
LEU A 235
 None
 0.80A 2einN-1kt8A:
0.0
2einW-1kt8A:
0.0		 2einN-1kt8A:
22.71
2einW-1kt8A:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_A_GBNA2414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 8 TYR A 141
ARG A 143
GLY A 312
THR A 313
ALA A 314
 ILP  A 400 (-4.5A)
None
ILP  A 400 (-3.5A)
ILP  A 400 (-3.6A)
ILP  A 400 ( 4.7A)
 0.50A 2ej3A-1kt8A:
30.7		 2ej3A-1kt8A:
27.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_B_GBNB914_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		7 / 10 PHE A  75
TYR A 141
ARG A 143
TYR A 207
GLY A 312
THR A 313
ALA A 314
 None
ILP  A 400 (-4.5A)
None
ILP  A 400 (-4.5A)
ILP  A 400 (-3.5A)
ILP  A 400 (-3.6A)
ILP  A 400 ( 4.7A)
 0.42A 2ej3B-1kt8A:
30.8		 2ej3B-1kt8A:
27.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_C_GBNC1414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 8 TYR A 141
ARG A 143
GLY A 312
THR A 313
ALA A 314
 ILP  A 400 (-4.5A)
None
ILP  A 400 (-3.5A)
ILP  A 400 (-3.6A)
ILP  A 400 ( 4.7A)
 0.52A 2ej3C-1kt8A:
30.5		 2ej3C-1kt8A:
27.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_A_HSMA145_1
(D7R4 PROTEIN)		 1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 ARG A 344
TYR A 246
PHE A 284
GLU A 283
 None
 1.02A 2qebA-1kt8A:
undetectable		 2qebA-1kt8A:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_B_HSMB145_1
(D7R4 PROTEIN)		 1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 ARG A 344
TYR A 246
PHE A 284
GLU A 283
 None
 1.04A 2qebB-1kt8A:
0.0		 2qebB-1kt8A:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 ILE A 332
MET A 293
THR A 292
LEU A 235
 None
 0.81A 3abkA-1kt8A:
0.0
3abkJ-1kt8A:
0.0		 3abkA-1kt8A:
22.71
3abkJ-1kt8A:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 ILE A 332
MET A 293
THR A 292
LEU A 235
 None
 0.84A 3ablA-1kt8A:
0.0
3ablJ-1kt8A:
0.0		 3ablA-1kt8A:
22.71
3ablJ-1kt8A:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 ILE A 332
MET A 293
THR A 292
LEU A 235
 None
 0.84A 3ablN-1kt8A:
0.0
3ablW-1kt8A:
0.0		 3ablN-1kt8A:
22.71
3ablW-1kt8A:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 ILE A 332
MET A 293
THR A 292
LEU A 235
 None
 0.82A 3abmN-1kt8A:
0.0
3abmW-1kt8A:
0.0		 3abmN-1kt8A:
22.71
3abmW-1kt8A:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 ILE A 332
MET A 293
THR A 292
LEU A 235
 None
 0.92A 3ag1N-1kt8A:
0.0
3ag1W-1kt8A:
0.0		 3ag1N-1kt8A:
22.71
3ag1W-1kt8A:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 ILE A 332
MET A 293
THR A 292
LEU A 235
 None
 0.79A 3ag3A-1kt8A:
undetectable
3ag3J-1kt8A:
0.0		 3ag3A-1kt8A:
22.71
3ag3J-1kt8A:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 ILE A 332
MET A 293
THR A 292
LEU A 235
 None
 0.82A 3ag3N-1kt8A:
undetectable
3ag3W-1kt8A:
0.0		 3ag3N-1kt8A:
22.71
3ag3W-1kt8A:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_W_CHDW1059_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 ILE A 332
MET A 293
THR A 292
LEU A 235
 None
 0.82A 3asnN-1kt8A:
0.0
3asnW-1kt8A:
0.0		 3asnN-1kt8A:
22.71
3asnW-1kt8A:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_W_CHDW1059_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 ILE A 332
MET A 293
THR A 292
LEU A 235
 None
 0.82A 3asoN-1kt8A:
0.0
3asoW-1kt8A:
0.0		 3asoN-1kt8A:
22.71
3asoW-1kt8A:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_A_SAMA226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU A  61
ASN A 206
GLY A 205
GLY A 148
LEU A 107
 None
 0.92A 3ku1A-1kt8A:
undetectable		 3ku1A-1kt8A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNE_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ASN A 242
GLY A 312
GLN A 316
LEU A  95
ILE A 265
 ILP  A 400 (-3.5A)
ILP  A 400 (-3.5A)
None
ACY  A1005 ( 4.8A)
None
 1.30A 3mneA-1kt8A:
undetectable		 3mneA-1kt8A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 ILE A 332
MET A 293
THR A 292
LEU A 235
 None
 0.83A 3wg7N-1kt8A:
0.0
3wg7W-1kt8A:
0.0		 3wg7N-1kt8A:
22.71
3wg7W-1kt8A:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_A_MIXA1301_1
(DNA TOPOISOMERASE
2-BETA)		 1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 GLY A 199
ILE A 265
ASN A 242
GLU A 237
 None
None
ILP  A 400 (-3.5A)
ILP  A 400 (-3.4A)
 1.10A 4g0vA-1kt8A:
undetectable		 4g0vA-1kt8A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_3
(HIV-1 PROTEASE)		 1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ASP A 232
LEU A 228
VAL A 264
 None
 0.59A 4jecB-1kt8A:
undetectable		 4jecB-1kt8A:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_3
(HIV-1 PROTEASE)		 1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ASP A 232
LEU A 235
VAL A 264
 None
 0.70A 4jecB-1kt8A:
undetectable		 4jecB-1kt8A:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLT_A_8PRA505_1
(CYTOCHROME P450 2B4)		 1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 ILE A 243
ILE A 323
VAL A 308
VAL A 257
 None
 0.76A 4jltA-1kt8A:
undetectable		 4jltA-1kt8A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLF_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 GLU A 288
VAL A 257
PRO A 259
TRP A 194
GLY A 199
 None
 1.22A 4olfA-1kt8A:
undetectable		 4olfA-1kt8A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_J_CHDJ102_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 ILE A 332
MET A 293
THR A 292
LEU A 235
 None
 0.84A 5b1aA-1kt8A:
0.0
5b1aJ-1kt8A:
undetectable		 5b1aA-1kt8A:
22.71
5b1aJ-1kt8A:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 ILE A 332
MET A 293
THR A 292
LEU A 235
 None
 0.84A 5b1bA-1kt8A:
undetectable
5b1bJ-1kt8A:
0.0		 5b1bA-1kt8A:
22.71
5b1bJ-1kt8A:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 ILE A 332
MET A 293
THR A 292
LEU A 235
 None
 0.84A 5b1bN-1kt8A:
0.0
5b1bW-1kt8A:
0.0		 5b1bN-1kt8A:
22.71
5b1bW-1kt8A:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 ILE A 332
MET A 293
THR A 292
LEU A 235
 None
 0.85A 5b3sA-1kt8A:
0.0
5b3sJ-1kt8A:
undetectable		 5b3sA-1kt8A:
22.71
5b3sJ-1kt8A:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 ILE A 332
MET A 293
THR A 292
LEU A 235
 None
 0.85A 5b3sN-1kt8A:
0.0
5b3sW-1kt8A:
0.0		 5b3sN-1kt8A:
22.71
5b3sW-1kt8A:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 ILE A 332
MET A 293
THR A 292
LEU A 235
 None
 0.85A 5iy5A-1kt8A:
0.0
5iy5J-1kt8A:
0.0		 5iy5A-1kt8A:
22.71
5iy5J-1kt8A:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 ILE A 332
MET A 293
THR A 292
LEU A 235
 None
 0.89A 5iy5N-1kt8A:
0.0
5iy5W-1kt8A:
0.0		 5iy5N-1kt8A:
22.71
5iy5W-1kt8A:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZF_E_AZ1E2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
6J9-ZEU-DAR-ACA-DAR-
NH2)		 1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 GLY A 312
SER A 311
LEU A 349
GLU A  76
 ILP  A 400 (-3.5A)
None
None
None
 0.79A 5izfA-1kt8A:
undetectable		 5izfA-1kt8A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAH_C_RFPC3001_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ARG A 220
LEU A 226
LEU A 296
PRO A 333
ILE A 332
 None
 1.35A 5uahC-1kt8A:
0.4		 5uahC-1kt8A:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 ILE A 332
MET A 293
THR A 292
LEU A 235
 None
 0.87A 5xdxA-1kt8A:
0.0
5xdxJ-1kt8A:
0.0		 5xdxA-1kt8A:
22.71
5xdxJ-1kt8A:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 ILE A 332
MET A 293
THR A 292
LEU A 235
 None
 0.86A 5xdxN-1kt8A:
0.0
5xdxW-1kt8A:
0.0		 5xdxN-1kt8A:
22.71
5xdxW-1kt8A:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_C_9CRC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ALA A 278
GLN A 279
TRP A 361
LEU A 256
LEU A 349
 None
 1.02A 5z12C-1kt8A:
undetectable		 5z12C-1kt8A:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 ILE A 332
MET A 293
THR A 292
LEU A 235
 None
 0.84A 5z86N-1kt8A:
0.0
5z86W-1kt8A:
0.0		 5z86N-1kt8A:
22.71
5z86W-1kt8A:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 ILE A 332
MET A 293
THR A 292
LEU A 235
 None
 0.84A 5zcoA-1kt8A:
0.0
5zcoJ-1kt8A:
0.0		 5zcoA-1kt8A:
22.71
5zcoJ-1kt8A:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 ILE A 332
MET A 293
THR A 292
LEU A 235
 None
 0.88A 5zcoN-1kt8A:
0.0
5zcoW-1kt8A:
0.0		 5zcoN-1kt8A:
22.71
5zcoW-1kt8A:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 ILE A 332
MET A 293
THR A 292
LEU A 235
 None
 0.84A 5zcpA-1kt8A:
0.0
5zcpJ-1kt8A:
undetectable		 5zcpA-1kt8A:
22.71
5zcpJ-1kt8A:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 ILE A 332
MET A 293
THR A 292
LEU A 235
 None
 0.86A 5zcpN-1kt8A:
0.0
5zcpW-1kt8A:
0.0		 5zcpN-1kt8A:
22.71
5zcpW-1kt8A:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 ILE A 332
MET A 293
THR A 292
LEU A 235
 None
 0.86A 5zcqA-1kt8A:
0.0
5zcqJ-1kt8A:
undetectable		 5zcqA-1kt8A:
22.71
5zcqJ-1kt8A:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 ILE A 332
MET A 293
THR A 292
LEU A 235
 None
 0.86A 5zcqN-1kt8A:
0.0
5zcqW-1kt8A:
0.0		 5zcqN-1kt8A:
22.71
5zcqW-1kt8A:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN8_A_HFGA603_0
(UNCHARACTERIZED
PROTEIN)		 1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 GLU A 288
VAL A 257
PRO A 259
TRP A 194
GLY A 199
 None
 1.20A 6mn8A-1kt8A:
undetectable		 6mn8A-1kt8A:
20.78