SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ktc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_V_TRPV81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1ktc ALPHA-N-ACETYLGALACT
OSAMINIDASE
(Gallus
gallus) 		5 / 12 GLY A 104
THR A 117
ALA A 126
GLY A 152
ALA A 159
 None
 1.04A 1gtnL-1ktcA:
undetectable
1gtnV-1ktcA:
undetectable		 1gtnL-1ktcA:
11.41
1gtnV-1ktcA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_A_SAMA501_0
(BIOTIN SYNTHASE)		 1ktc ALPHA-N-ACETYLGALACT
OSAMINIDASE
(Gallus
gallus) 		5 / 12 ARG A  81
ILE A  60
LEU A 100
VAL A 134
LEU A  75
 None
 1.22A 1r30A-1ktcA:
7.0		 1r30A-1ktcA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_B_D16B568_1
(THYMIDYLATE SYNTHASE)		 1ktc ALPHA-N-ACETYLGALACT
OSAMINIDASE
(Gallus
gallus) 		5 / 12 LEU A 312
ASP A 292
LEU A 294
GLY A 295
ALA A 319
 GOL  A1101 (-4.4A)
None
GOL  A1107 ( 4.9A)
None
GOL  A1106 (-4.1A)
 1.10A 2kceB-1ktcA:
0.0		 2kceB-1ktcA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_B_FUAB2002_1
(SERUM ALBUMIN)		 1ktc ALPHA-N-ACETYLGALACT
OSAMINIDASE
(Gallus
gallus) 		4 / 9 ILE A 102
ALA A 130
VAL A 134
LYS A  99
 None
 1.05A 2vufB-1ktcA:
undetectable		 2vufB-1ktcA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCP_B_CHDB4_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1ktc ALPHA-N-ACETYLGALACT
OSAMINIDASE
(Gallus
gallus) 		3 / 3 GLY A 230
PRO A  10
LEU A 195
 None
 0.63A 3hcpB-1ktcA:
3.1		 3hcpB-1ktcA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_D_ACTD504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 1ktc ALPHA-N-ACETYLGALACT
OSAMINIDASE
(Gallus
gallus) 		3 / 3 GLY A 378
SER A 377
TRP A 206
 None
 0.54A 4e7cD-1ktcA:
0.0		 4e7cD-1ktcA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_B_9TPB601_2
(SERUM ALBUMIN)		 1ktc ALPHA-N-ACETYLGALACT
OSAMINIDASE
(Gallus
gallus) 		4 / 4 ARG A  74
GLU A 123
ASP A  70
ARG A  69
 None
 1.46A 4l9qB-1ktcA:
0.0		 4l9qB-1ktcA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MUB_A_OAQA302_0
(SULFOTRANSFERASE)		 1ktc ALPHA-N-ACETYLGALACT
OSAMINIDASE
(Gallus
gallus) 		5 / 12 PRO A 263
MET A 237
LEU A 265
GLY A 141
ASP A 140
 None
None
None
None
NGA  A 870 (-3.0A)
 1.40A 4mubA-1ktcA:
undetectable		 4mubA-1ktcA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_E_PARE500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 1ktc ALPHA-N-ACETYLGALACT
OSAMINIDASE
(Gallus
gallus) 		5 / 12 SER A 145
GLU A 123
ASP A 120
TYR A 153
GLY A 152
 SO4  A2102 (-4.7A)
None
None
None
None
 1.37A 4qb9E-1ktcA:
0.0		 4qb9E-1ktcA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_1
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 1ktc ALPHA-N-ACETYLGALACT
OSAMINIDASE
(Gallus
gallus) 		3 / 3 SER A 172
TYR A 176
ASP A  61
 NGA  A 870 (-2.6A)
None
NGA  A 870 (-2.9A)
 0.89A 4rp8C-1ktcA:
0.0		 4rp8C-1ktcA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_2
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 1ktc ALPHA-N-ACETYLGALACT
OSAMINIDASE
(Gallus
gallus) 		3 / 3 VAL A 355
ARG A 299
PRO A 314
 None
GOL  A1104 (-3.4A)
GOL  A1101 (-4.1A)
 0.83A 5koxA-1ktcA:
undetectable		 5koxA-1ktcA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA310_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1ktc ALPHA-N-ACETYLGALACT
OSAMINIDASE
(Gallus
gallus) 		3 / 3 GLU A 309
HIS A 307
ARG A 328
 None
SO4  A2104 (-3.8A)
None
 0.73A 5uunA-1ktcA:
0.0		 5uunA-1ktcA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 1ktc ALPHA-N-ACETYLGALACT
OSAMINIDASE
(Gallus
gallus) 		3 / 3 LYS A 303
LEU A 256
ASP A 214
 None
 0.68A 5zv2A-1ktcA:
undetectable		 5zv2A-1ktcA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1ktc ALPHA-N-ACETYLGALACT
OSAMINIDASE
(Gallus
gallus) 		3 / 3 LEU A 160
ASN A  59
LEU A 195
 None
 0.75A 6exiD-1ktcA:
undetectable		 6exiD-1ktcA:
13.82