SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ktn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4002_1
(SERUM ALBUMIN)		 1ktn 2-DEOXYRIBOSE-5-PHOS
PHATE ALDOLASE
(Escherichia
coli) 		4 / 4 ARG A 183
ALA A 182
ALA A 219
GLU A 221
 None
 1.10A 1e7bA-1ktnA:
undetectable		 1e7bA-1ktnA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_B_HLTB4002_1
(SERUM ALBUMIN)		 1ktn 2-DEOXYRIBOSE-5-PHOS
PHATE ALDOLASE
(Escherichia
coli) 		4 / 4 ARG A 183
ALA A 182
ALA A 219
GLU A 221
 None
 1.17A 1e7bB-1ktnA:
undetectable		 1e7bB-1ktnA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4002_1
(SERUM ALBUMIN)		 1ktn 2-DEOXYRIBOSE-5-PHOS
PHATE ALDOLASE
(Escherichia
coli) 		4 / 5 ARG A 183
ALA A 182
ALA A 219
GLU A 221
 None
 1.19A 1e7cA-1ktnA:
undetectable		 1e7cA-1ktnA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J8U_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1ktn 2-DEOXYRIBOSE-5-PHOS
PHATE ALDOLASE
(Escherichia
coli) 		4 / 7 VAL A  40
LEU A 245
SER A 243
LEU A 240
 None
 0.65A 1j8uA-1ktnA:
undetectable		 1j8uA-1ktnA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KW0_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1ktn 2-DEOXYRIBOSE-5-PHOS
PHATE ALDOLASE
(Escherichia
coli) 		5 / 12 VAL A  40
LEU A   9
SER A   7
LEU A   4
THR A  38
 None
 1.17A 1kw0A-1ktnA:
undetectable		 1kw0A-1ktnA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_F_AG2F7016_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 1ktn 2-DEOXYRIBOSE-5-PHOS
PHATE ALDOLASE
(Escherichia
coli) 		4 / 8 LEU A   4
LEU A 248
GLY A 249
GLU A 210
 None
 0.90A 1n13A-1ktnA:
0.0
1n13F-1ktnA:
undetectable		 1n13A-1ktnA:
17.72
1n13F-1ktnA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_H_AG2H7012_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 1ktn 2-DEOXYRIBOSE-5-PHOS
PHATE ALDOLASE
(Escherichia
coli) 		4 / 6 GLU A 210
LEU A   4
LEU A 248
GLY A 249
 None
 0.93A 1n13H-1ktnA:
0.0
1n13K-1ktnA:
0.0		 1n13H-1ktnA:
19.51
1n13K-1ktnA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_J_AG2J7013_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 1ktn 2-DEOXYRIBOSE-5-PHOS
PHATE ALDOLASE
(Escherichia
coli) 		4 / 7 LEU A   4
LEU A 248
GLY A 249
GLU A 210
 None
 0.89A 1n13G-1ktnA:
0.0
1n13J-1ktnA:
0.0		 1n13G-1ktnA:
17.72
1n13J-1ktnA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG7_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 1ktn 2-DEOXYRIBOSE-5-PHOS
PHATE ALDOLASE
(Escherichia
coli) 		3 / 3 ILE A  46
ILE A  70
THR A  19
 None
 0.57A 1rg7A-1ktnA:
undetectable		 1rg7A-1ktnA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1ktn 2-DEOXYRIBOSE-5-PHOS
PHATE ALDOLASE
(Escherichia
coli) 		4 / 5 ASP A 102
GLY A 199
PRO A 202
ALA A 203
 None
 0.95A 2aofA-1ktnA:
undetectable		 2aofA-1ktnA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1ktn 2-DEOXYRIBOSE-5-PHOS
PHATE ALDOLASE
(Escherichia
coli) 		4 / 5 ASP A 102
GLY A 199
PRO A 202
ALA A 203
 None
 0.97A 2aohA-1ktnA:
undetectable		 2aohA-1ktnA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		 1ktn 2-DEOXYRIBOSE-5-PHOS
PHATE ALDOLASE
(Escherichia
coli) 		5 / 12 LEU A 241
ILE A  68
THR A  65
GLN A  63
HIS A 250
 None
 1.09A 2jn3A-1ktnA:
undetectable		 2jn3A-1ktnA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1103_0
(FERROCHELATASE)		 1ktn 2-DEOXYRIBOSE-5-PHOS
PHATE ALDOLASE
(Escherichia
coli) 		4 / 8 MET A  15
LEU A  17
PRO A 202
GLY A 205
 None
 1.05A 2qd5B-1ktnA:
undetectable		 2qd5B-1ktnA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_B_AG2B671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1ktn 2-DEOXYRIBOSE-5-PHOS
PHATE ALDOLASE
(Escherichia
coli) 		4 / 8 GLU A 210
LEU A   4
LEU A 248
GLY A 249
 None
 0.86A 2qqdB-1ktnA:
undetectable
2qqdC-1ktnA:
undetectable		 2qqdB-1ktnA:
24.12
2qqdC-1ktnA:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A35_A_RBFA191_1
(LUMAZINE PROTEIN)		 1ktn 2-DEOXYRIBOSE-5-PHOS
PHATE ALDOLASE
(Escherichia
coli) 		5 / 12 CYH A 129
LEU A 136
ASP A 102
THR A  90
ILE A  94
 None
 1.14A 3a35A-1ktnA:
undetectable		 3a35A-1ktnA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A35_B_RBFB191_1
(LUMAZINE PROTEIN)		 1ktn 2-DEOXYRIBOSE-5-PHOS
PHATE ALDOLASE
(Escherichia
coli) 		5 / 12 CYH A 129
LEU A 136
ASP A 102
THR A  90
ILE A  94
 None
 1.18A 3a35B-1ktnA:
undetectable		 3a35B-1ktnA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A3B_A_RBFA191_1
(LUMAZINE PROTEIN)		 1ktn 2-DEOXYRIBOSE-5-PHOS
PHATE ALDOLASE
(Escherichia
coli) 		5 / 12 CYH A 129
LEU A 136
ASP A 102
THR A  90
ILE A  94
 None
 1.13A 3a3bA-1ktnA:
undetectable		 3a3bA-1ktnA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_A_SAMA300_0
(PUTATIVE RRNA
METHYLASE)		 1ktn 2-DEOXYRIBOSE-5-PHOS
PHATE ALDOLASE
(Escherichia
coli) 		5 / 12 THR A  25
ASN A  21
ASP A  23
ILE A  55
LEU A  32
 None
 1.11A 3eeyA-1ktnA:
undetectable		 3eeyA-1ktnA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_B_SAMB300_0
(PUTATIVE RRNA
METHYLASE)		 1ktn 2-DEOXYRIBOSE-5-PHOS
PHATE ALDOLASE
(Escherichia
coli) 		5 / 12 THR A  25
ASN A  21
ASP A  23
ILE A  55
LEU A  32
 None
 1.11A 3eeyB-1ktnA:
undetectable		 3eeyB-1ktnA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_I_SAMI300_0
(PUTATIVE RRNA
METHYLASE)		 1ktn 2-DEOXYRIBOSE-5-PHOS
PHATE ALDOLASE
(Escherichia
coli) 		5 / 12 THR A  25
ASN A  21
ASP A  23
ILE A  55
LEU A  32
 None
 1.08A 3eeyI-1ktnA:
undetectable		 3eeyI-1ktnA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F33_A_PFLA2001_1
(FERRITIN LIGHT CHAIN)		 1ktn 2-DEOXYRIBOSE-5-PHOS
PHATE ALDOLASE
(Escherichia
coli) 		4 / 6 LEU A 240
SER A 239
ARG A 207
LEU A 244
 None
 1.04A 3f33A-1ktnA:
undetectable		 3f33A-1ktnA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_A_CHDA3_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1ktn 2-DEOXYRIBOSE-5-PHOS
PHATE ALDOLASE
(Escherichia
coli) 		4 / 7 MET A  15
LEU A  17
PRO A 202
GLY A 205
 None
 1.10A 3hcnA-1ktnA:
undetectable		 3hcnA-1ktnA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_A_BEZA264_0
(CARNITINYL-COA
DEHYDRATASE)		 1ktn 2-DEOXYRIBOSE-5-PHOS
PHATE ALDOLASE
(Escherichia
coli) 		4 / 6 ILE A 140
LEU A 145
GLU A 156
ALA A 149
 None
 0.87A 3r9sA-1ktnA:
undetectable		 3r9sA-1ktnA:
27.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_B_BEZB264_0
(ECHA1_1)		 1ktn 2-DEOXYRIBOSE-5-PHOS
PHATE ALDOLASE
(Escherichia
coli) 		4 / 7 ILE A 140
LEU A 145
GLU A 156
ALA A 149
 None
 0.81A 3r9tB-1ktnA:
undetectable		 3r9tB-1ktnA:
27.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAV_A_RAVA183_1
(FERRITIN LIGHT CHAIN)		 1ktn 2-DEOXYRIBOSE-5-PHOS
PHATE ALDOLASE
(Escherichia
coli) 		4 / 6 LEU A 240
SER A 239
ARG A 207
LEU A 244
 None
 1.01A 3ravA-1ktnA:
undetectable		 3ravA-1ktnA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_2
(CYCLIN-DEPENDENT
KINASE 8)		 1ktn 2-DEOXYRIBOSE-5-PHOS
PHATE ALDOLASE
(Escherichia
coli) 		5 / 7 LEU A  20
VAL A  73
LEU A 240
ASP A  16
MET A  15
 None
 1.13A 3rgfA-1ktnA:
undetectable		 3rgfA-1ktnA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB6_C_VLBC503_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 1ktn 2-DEOXYRIBOSE-5-PHOS
PHATE ALDOLASE
(Escherichia
coli) 		5 / 12 ASP A  24
PRO A  54
ILE A  46
VAL A  29
ILE A  55
 None
 1.35A 4eb6B-1ktnA:
undetectable
4eb6C-1ktnA:
undetectable		 4eb6B-1ktnA:
17.81
4eb6C-1ktnA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 1ktn 2-DEOXYRIBOSE-5-PHOS
PHATE ALDOLASE
(Escherichia
coli) 		5 / 12 ILE A  53
ALA A  71
LEU A  20
PRO A  77
ARG A  51
 None
 1.19A 4gh8B-1ktnA:
undetectable		 4gh8B-1ktnA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDR_A_ADNA402_1
(FAD:PROTEIN FMN
TRANSFERASE)		 1ktn 2-DEOXYRIBOSE-5-PHOS
PHATE ALDOLASE
(Escherichia
coli) 		5 / 12 VAL A 138
GLY A 162
ALA A 161
ILE A 157
PRO A 106
 None
 0.94A 4xdrA-1ktnA:
0.0		 4xdrA-1ktnA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 1ktn 2-DEOXYRIBOSE-5-PHOS
PHATE ALDOLASE
(Escherichia
coli) 		6 / 12 ALA A 177
PRO A 202
GLY A 171
GLY A 204
GLY A 236
ALA A 174
 None
 1.21A 5c0oG-1ktnA:
undetectable		 5c0oG-1ktnA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGY_A_ERYA403_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 1ktn 2-DEOXYRIBOSE-5-PHOS
PHATE ALDOLASE
(Escherichia
coli) 		5 / 12 ASN A 176
PHE A  76
ILE A 166
PHE A 165
MET A 185
 None
 1.23A 5igyA-1ktnA:
undetectable		 5igyA-1ktnA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1103_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 1ktn 2-DEOXYRIBOSE-5-PHOS
PHATE ALDOLASE
(Escherichia
coli) 		4 / 8 PRO A 179
TYR A 215
VAL A 206
GLY A 205
 None
 0.99A 5nzyA-1ktnA:
2.6		 5nzyA-1ktnA:
18.49