SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ku1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VM1_A_TAZA504_1
(BETA-LACTAMASE SHV-1)		 1ku1 ARF
GUANINE-NUCLEOTIDE
EXCHANGE FACTOR 2
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 745
TYR A 748
GLU A 724
 None
 0.49A 1vm1A-1ku1A:
undetectable		 1vm1A-1ku1A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA502_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 1ku1 ARF
GUANINE-NUCLEOTIDE
EXCHANGE FACTOR 2
(Saccharomyces
cerevisiae) 		3 / 3 LEU A 614
HIS A 617
LYS A 620
 None
 1.02A 1y7iA-1ku1A:
undetectable		 1y7iA-1ku1A:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_D_TOPD1158_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 1ku1 ARF
GUANINE-NUCLEOTIDE
EXCHANGE FACTOR 2
(Saccharomyces
cerevisiae) 		5 / 10 ILE A 751
LEU A 646
ILE A 756
TYR A 726
THR A 710
 None
 1.16A 2w9sD-1ku1A:
undetectable		 2w9sD-1ku1A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_F_TOPF1159_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 1ku1 ARF
GUANINE-NUCLEOTIDE
EXCHANGE FACTOR 2
(Saccharomyces
cerevisiae) 		5 / 10 ILE A 751
LEU A 646
ILE A 756
TYR A 726
THR A 710
 None
 1.19A 2w9sF-1ku1A:
undetectable		 2w9sF-1ku1A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_B_ACTB501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 1ku1 ARF
GUANINE-NUCLEOTIDE
EXCHANGE FACTOR 2
(Saccharomyces
cerevisiae) 		4 / 6 ARG A 637
VAL A 638
ILE A 705
TYR A 743
 None
 1.19A 2yfbB-1ku1A:
undetectable		 2yfbB-1ku1A:
27.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_B_MTXB164_2
(DIHYDROFOLATE
REDUCTASE)		 1ku1 ARF
GUANINE-NUCLEOTIDE
EXCHANGE FACTOR 2
(Saccharomyces
cerevisiae) 		4 / 4 PHE A 649
LYS A 648
ILE A 661
THR A 610
 None
 1.38A 3ia4B-1ku1A:
undetectable		 3ia4B-1ku1A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_SALB900_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1ku1 ARF
GUANINE-NUCLEOTIDE
EXCHANGE FACTOR 2
(Saccharomyces
cerevisiae) 		4 / 5 VAL A 698
LEU A 701
ILE A 642
ALA A 641
 None
 0.92A 3n8yB-1ku1A:
undetectable		 3n8yB-1ku1A:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWR_A_ZMRA513_2
(NEURAMINIDASE)		 1ku1 ARF
GUANINE-NUCLEOTIDE
EXCHANGE FACTOR 2
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 636
ASP A 639
ARG A 643
ILE A 756
 None
 1.48A 4mwrA-1ku1A:
undetectable		 4mwrA-1ku1A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R82_A_ACTA205_0
(OXIDOREDUCTASE)		 1ku1 ARF
GUANINE-NUCLEOTIDE
EXCHANGE FACTOR 2
(Saccharomyces
cerevisiae) 		4 / 5 SER A 727
GLY A 728
GLU A 724
PHE A 723
 None
 0.81A 4r82A-1ku1A:
undetectable
4r82B-1ku1A:
undetectable		 4r82A-1ku1A:
19.59
4r82B-1ku1A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_2_BEZ2801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 1ku1 ARF
GUANINE-NUCLEOTIDE
EXCHANGE FACTOR 2
(Saccharomyces
cerevisiae) 		4 / 4 LEU A 712
ARG A 643
ILE A 751
ILE A 756
 None
 1.42A 5dzk2-1ku1A:
undetectable
5dzkM-1ku1A:
undetectable
5dzkN-1ku1A:
undetectable		 5dzk2-1ku1A:
1.82
5dzkM-1ku1A:
21.90
5dzkN-1ku1A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS5_A_ASCA202_0
(CYTOCHROME C')		 1ku1 ARF
GUANINE-NUCLEOTIDE
EXCHANGE FACTOR 2
(Saccharomyces
cerevisiae) 		3 / 3 CYH A 734
LYS A 737
HIS A 736
 None
 1.12A 5js5A-1ku1A:
undetectable		 5js5A-1ku1A:
22.68