SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ku2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1503_0
(FERROCHELATASE)		 1ku2 SIGMA FACTOR SIGA
(Thermus
aquaticus) 		3 / 3 LEU A 181
PRO A 182
LEU A 185
 None
 0.54A 1hrkA-1ku2A:
undetectable		 1hrkA-1ku2A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_G_RBFG200_1
(DODECIN)		 1ku2 SIGMA FACTOR SIGA
(Thermus
aquaticus) 		4 / 8 ARG A 147
HIS A 201
ARG A 155
GLN A 157
 None
 1.36A 2vxaF-1ku2A:
undetectable
2vxaG-1ku2A:
undetectable
2vxaI-1ku2A:
undetectable		 2vxaF-1ku2A:
19.14
2vxaG-1ku2A:
19.14
2vxaI-1ku2A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJW_A_SRYA2001_2
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1ku2 SIGMA FACTOR SIGA
(Thermus
aquaticus) 		4 / 6 GLU A 196
ILE A 150
GLU A 102
VAL A 106
 None
 1.11A 4ejwB-1ku2A:
1.7		 4ejwB-1ku2A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1ku2 SIGMA FACTOR SIGA
(Thermus
aquaticus) 		4 / 9 SER A 251
ALA A 254
LEU A 202
ILE A 115
 None
 0.82A 4xtaA-1ku2A:
undetectable		 4xtaA-1ku2A:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB307_0
(WELO5)		 1ku2 SIGMA FACTOR SIGA
(Thermus
aquaticus) 		3 / 3 GLU A 281
HIS A 278
VAL A 277
 None
 0.93A 5trqB-1ku2A:
undetectable		 5trqB-1ku2A:
21.97