SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1kug'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS2_A_HAEA874_1
(MACROPHAGE
METALLOELASTASE)		 1kug METALLOPROTEINASE
(Protobothrops
mucrosquamatus) 		4 / 5 HIS A 144
GLU A 145
HIS A 148
HIS A 154
 CD  A 981 (-3.5A)
CD  A 981 ( 4.6A)
CD  A 981 (-3.4A)
CD  A 981 (-3.4A)
 0.27A 1os2A-1kugA:
10.7		 1os2A-1kugA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS2_D_HAED574_1
(MACROPHAGE
METALLOELASTASE)		 1kug METALLOPROTEINASE
(Protobothrops
mucrosquamatus) 		4 / 4 HIS A 144
GLU A 145
HIS A 148
HIS A 154
 CD  A 981 (-3.5A)
CD  A 981 ( 4.6A)
CD  A 981 (-3.4A)
CD  A 981 (-3.4A)
 0.24A 1os2D-1kugA:
10.8		 1os2D-1kugA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_D_DEXD4999_2
(GLUCOCORTICOID
RECEPTOR)		 1kug METALLOPROTEINASE
(Protobothrops
mucrosquamatus) 		4 / 5 LEU A 100
TRP A  83
LEU A  58
GLN A  98
 None
 1.47A 1p93D-1kugA:
0.0		 1p93D-1kugA:
19.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1R55_A_097A518_1
(ADAM 33)		 1kug METALLOPROTEINASE
(Protobothrops
mucrosquamatus) 		6 / 10 THR A 109
THR A 141
HIS A 144
GLU A 145
HIS A 148
HIS A 154
 None
None
CD  A 981 (-3.5A)
CD  A 981 ( 4.6A)
CD  A 981 (-3.4A)
CD  A 981 (-3.4A)
 0.33A 1r55A-1kugA:
31.4		 1r55A-1kugA:
34.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTT_A_HAEA1265_1
(MACROPHAGE
METALLOELASTASE)		 1kug METALLOPROTEINASE
(Protobothrops
mucrosquamatus) 		4 / 4 HIS A 144
GLU A 145
HIS A 148
HIS A 154
 CD  A 981 (-3.5A)
CD  A 981 ( 4.6A)
CD  A 981 (-3.4A)
CD  A 981 (-3.4A)
 0.19A 1uttA-1kugA:
11.2		 1uttA-1kugA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTZ_A_HAEA1267_1
(MACROPHAGE
METALLOELASTASE)		 1kug METALLOPROTEINASE
(Protobothrops
mucrosquamatus) 		4 / 4 HIS A 144
GLU A 145
HIS A 148
HIS A 154
 CD  A 981 (-3.5A)
CD  A 981 ( 4.6A)
CD  A 981 (-3.4A)
CD  A 981 (-3.4A)
 0.26A 1utzA-1kugA:
11.0		 1utzA-1kugA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTZ_B_HAEB1266_1
(MACROPHAGE
METALLOELASTASE)		 1kug METALLOPROTEINASE
(Protobothrops
mucrosquamatus) 		4 / 4 HIS A 144
GLU A 145
HIS A 148
HIS A 154
 CD  A 981 (-3.5A)
CD  A 981 ( 4.6A)
CD  A 981 (-3.4A)
CD  A 981 (-3.4A)
 0.25A 1utzB-1kugA:
11.1		 1utzB-1kugA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UUJ_B_ACTB1077_0
(PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE IB
ALPHA SUBUNIT)		 1kug METALLOPROTEINASE
(Protobothrops
mucrosquamatus) 		3 / 3 ARG A  34
TYR A  24
LYS A  23
 None
 0.97A 1uujB-1kugA:
0.0		 1uujB-1kugA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_A_CUA517_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I)		 1kug METALLOPROTEINASE
(Protobothrops
mucrosquamatus) 		3 / 3 HIS A 154
HIS A 148
HIS A 144
 CD  A 981 (-3.4A)
CD  A 981 (-3.4A)
CD  A 981 (-3.5A)
 0.76A 1v54A-1kugA:
0.0		 1v54A-1kugA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_N_CUN517_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I)		 1kug METALLOPROTEINASE
(Protobothrops
mucrosquamatus) 		3 / 3 HIS A 154
HIS A 148
HIS A 144
 CD  A 981 (-3.4A)
CD  A 981 (-3.4A)
CD  A 981 (-3.5A)
 0.77A 1v54N-1kugA:
0.0		 1v54N-1kugA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_A_CUA517_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I)		 1kug METALLOPROTEINASE
(Protobothrops
mucrosquamatus) 		3 / 3 HIS A 154
HIS A 148
HIS A 144
 CD  A 981 (-3.4A)
CD  A 981 (-3.4A)
CD  A 981 (-3.5A)
 0.75A 1v55A-1kugA:
0.0		 1v55A-1kugA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_N_CUN517_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I)		 1kug METALLOPROTEINASE
(Protobothrops
mucrosquamatus) 		3 / 3 HIS A 154
HIS A 148
HIS A 144
 CD  A 981 (-3.4A)
CD  A 981 (-3.4A)
CD  A 981 (-3.5A)
 0.75A 1v55N-1kugA:
0.0		 1v55N-1kugA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y93_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 1kug METALLOPROTEINASE
(Protobothrops
mucrosquamatus) 		4 / 6 HIS A 144
GLU A 145
HIS A 148
HIS A 154
 CD  A 981 (-3.5A)
CD  A 981 ( 4.6A)
CD  A 981 (-3.4A)
CD  A 981 (-3.4A)
 0.23A 1y93A-1kugA:
11.1		 1y93A-1kugA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGY_A_BRLA503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 1kug METALLOPROTEINASE
(Protobothrops
mucrosquamatus) 		5 / 5 ILE A  14
ILE A 199
ILE A  42
MET A 142
LEU A  89
 None
 1.40A 1zgyA-1kugA:
undetectable		 1zgyA-1kugA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_A_LEUA1894_0
(AMINOACYL-TRNA
SYNTHETASE)		 1kug METALLOPROTEINASE
(Protobothrops
mucrosquamatus) 		4 / 8 ASP A 155
SER A 183
TYR A 186
HIS A 144
 None
None
None
CD  A 981 (-3.5A)
 1.22A 2bteA-1kugA:
1.0		 2bteA-1kugA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1kug METALLOPROTEINASE
(Protobothrops
mucrosquamatus) 		3 / 3 HIS A 154
HIS A 148
HIS A 144
 CD  A 981 (-3.4A)
CD  A 981 (-3.4A)
CD  A 981 (-3.5A)
 0.75A 2dyrA-1kugA:
0.0		 2dyrA-1kugA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1kug METALLOPROTEINASE
(Protobothrops
mucrosquamatus) 		3 / 3 HIS A 154
HIS A 148
HIS A 144
 CD  A 981 (-3.4A)
CD  A 981 (-3.4A)
CD  A 981 (-3.5A)
 0.76A 2dyrN-1kugA:
0.0		 2dyrN-1kugA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1kug METALLOPROTEINASE
(Protobothrops
mucrosquamatus) 		3 / 3 HIS A 154
HIS A 148
HIS A 144
 CD  A 981 (-3.4A)
CD  A 981 (-3.4A)
CD  A 981 (-3.5A)
 0.73A 2eijA-1kugA:
0.0		 2eijA-1kugA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1kug METALLOPROTEINASE
(Protobothrops
mucrosquamatus) 		3 / 3 HIS A 154
HIS A 148
HIS A 144
 CD  A 981 (-3.4A)
CD  A 981 (-3.4A)
CD  A 981 (-3.5A)
 0.75A 2eijN-1kugA:
0.0		 2eijN-1kugA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1kug METALLOPROTEINASE
(Protobothrops
mucrosquamatus) 		3 / 3 HIS A 154
HIS A 148
HIS A 144
 CD  A 981 (-3.4A)
CD  A 981 (-3.4A)
CD  A 981 (-3.5A)
 0.75A 2eimA-1kugA:
undetectable		 2eimA-1kugA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1kug METALLOPROTEINASE
(Protobothrops
mucrosquamatus) 		3 / 3 HIS A 154
HIS A 148
HIS A 144
 CD  A 981 (-3.4A)
CD  A 981 (-3.4A)
CD  A 981 (-3.5A)
 0.75A 2eimN-1kugA:
undetectable		 2eimN-1kugA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1kug METALLOPROTEINASE
(Protobothrops
mucrosquamatus) 		3 / 3 HIS A 154
HIS A 148
HIS A 144
 CD  A 981 (-3.4A)
CD  A 981 (-3.4A)
CD  A 981 (-3.5A)
 0.72A 2einN-1kugA:
undetectable		 2einN-1kugA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HU6_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		 1kug METALLOPROTEINASE
(Protobothrops
mucrosquamatus) 		4 / 4 HIS A 144
GLU A 145
HIS A 148
HIS A 154
 CD  A 981 (-3.5A)
CD  A 981 ( 4.6A)
CD  A 981 (-3.4A)
CD  A 981 (-3.4A)
 0.18A 2hu6A-1kugA:
11.1		 2hu6A-1kugA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_A_097A1001_1
(ADAMTS-1)		 1kug METALLOPROTEINASE
(Protobothrops
mucrosquamatus) 		5 / 9 THR A 141
HIS A 144
GLU A 145
HIS A 148
HIS A 154
 None
CD  A 981 (-3.5A)
CD  A 981 ( 4.6A)
CD  A 981 (-3.4A)
CD  A 981 (-3.4A)
 0.23A 2jihA-1kugA:
26.7		 2jihA-1kugA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_B_097B1001_1
(ADAMTS-1)		 1kug METALLOPROTEINASE
(Protobothrops
mucrosquamatus) 		5 / 8 THR A 141
HIS A 144
GLU A 145
HIS A 148
HIS A 154
 None
CD  A 981 (-3.5A)
CD  A 981 ( 4.6A)
CD  A 981 (-3.4A)
CD  A 981 (-3.4A)
 0.27A 2jihB-1kugA:
26.8		 2jihB-1kugA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		 1kug METALLOPROTEINASE
(Protobothrops
mucrosquamatus) 		4 / 6 HIS A 144
GLU A 145
HIS A 148
HIS A 154
 CD  A 981 (-3.5A)
CD  A 981 ( 4.6A)
CD  A 981 (-3.4A)
CD  A 981 (-3.4A)
 0.30A 2ow9A-1kugA:
10.7		 2ow9A-1kugA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_B_HAEB502_1
(COLLAGENASE 3)		 1kug METALLOPROTEINASE
(Protobothrops
mucrosquamatus) 		4 / 4 HIS A 144
GLU A 145
HIS A 148
HIS A 154
 CD  A 981 (-3.5A)
CD  A 981 ( 4.6A)
CD  A 981 (-3.4A)
CD  A 981 (-3.4A)
 0.30A 2ow9B-1kugA:
10.6		 2ow9B-1kugA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_C_HAEC3001_1
(COLLAGENASE 3)		 1kug METALLOPROTEINASE
(Protobothrops
mucrosquamatus) 		4 / 4 HIS A 144
GLU A 145
HIS A 148
HIS A 154
 CD  A 981 (-3.5A)
CD  A 981 ( 4.6A)
CD  A 981 (-3.4A)
CD  A 981 (-3.4A)
 0.31A 2ozrC-1kugA:
10.4		 2ozrC-1kugA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_D_HAED3002_1
(COLLAGENASE 3)		 1kug METALLOPROTEINASE
(Protobothrops
mucrosquamatus) 		4 / 4 HIS A 144
GLU A 145
HIS A 148
HIS A 154
 CD  A 981 (-3.5A)
CD  A 981 ( 4.6A)
CD  A 981 (-3.4A)
CD  A 981 (-3.4A)
 0.34A 2ozrD-1kugA:
10.5		 2ozrD-1kugA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_E_HAEE3003_1
(COLLAGENASE 3)		 1kug METALLOPROTEINASE
(Protobothrops
mucrosquamatus) 		4 / 4 HIS A 144
GLU A 145
HIS A 148
HIS A 154
 CD  A 981 (-3.5A)
CD  A 981 ( 4.6A)
CD  A 981 (-3.4A)
CD  A 981 (-3.4A)
 0.30A 2ozrE-1kugA:
10.6		 2ozrE-1kugA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_F_HAEF3004_1
(COLLAGENASE 3)		 1kug METALLOPROTEINASE
(Protobothrops
mucrosquamatus) 		3 / 3 HIS A 144
HIS A 148
HIS A 154
 CD  A 981 (-3.5A)
CD  A 981 (-3.4A)
CD  A 981 (-3.4A)
 0.24A 2ozrF-1kugA:
10.4		 2ozrF-1kugA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0G_A_LEUA1887_0
(AMINOACYL-TRNA
SYNTHETASE)		 1kug METALLOPROTEINASE
(Protobothrops
mucrosquamatus) 		4 / 8 ASP A 155
SER A 183
TYR A 186
HIS A 144
 None
None
None
CD  A 981 (-3.5A)
 1.37A 2v0gA-1kugA:
0.7		 2v0gA-1kugA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1kug METALLOPROTEINASE
(Protobothrops
mucrosquamatus) 		3 / 3 HIS A 154
HIS A 148
HIS A 144
 CD  A 981 (-3.4A)
CD  A 981 (-3.4A)
CD  A 981 (-3.5A)
 0.74A 3ag1A-1kugA:
undetectable		 3ag1A-1kugA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1kug METALLOPROTEINASE
(Protobothrops
mucrosquamatus) 		3 / 3 HIS A 154
HIS A 148
HIS A 144
 CD  A 981 (-3.4A)
CD  A 981 (-3.4A)
CD  A 981 (-3.5A)
 0.76A 3ag4N-1kugA:
0.0		 3ag4N-1kugA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_A_CUA1023_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1kug METALLOPROTEINASE
(Protobothrops
mucrosquamatus) 		3 / 3 HIS A 154
HIS A 148
HIS A 144
 CD  A 981 (-3.4A)
CD  A 981 (-3.4A)
CD  A 981 (-3.5A)
 0.75A 3dtuA-1kugA:
0.0		 3dtuA-1kugA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_C_CUC569_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1kug METALLOPROTEINASE
(Protobothrops
mucrosquamatus) 		3 / 3 HIS A 154
HIS A 148
HIS A 144
 CD  A 981 (-3.4A)
CD  A 981 (-3.4A)
CD  A 981 (-3.5A)
 0.75A 3dtuC-1kugA:
undetectable		 3dtuC-1kugA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_A_097A801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 1kug METALLOPROTEINASE
(Protobothrops
mucrosquamatus) 		5 / 9 THR A 141
HIS A 144
GLU A 145
HIS A 148
HIS A 154
 None
CD  A 981 (-3.5A)
CD  A 981 ( 4.6A)
CD  A 981 (-3.4A)
CD  A 981 (-3.4A)
 0.21A 3hy7A-1kugA:
27.1		 3hy7A-1kugA:
29.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_B_097B801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 1kug METALLOPROTEINASE
(Protobothrops
mucrosquamatus) 		5 / 9 THR A 141
HIS A 144
GLU A 145
HIS A 148
HIS A 154
 None
CD  A 981 (-3.5A)
CD  A 981 ( 4.6A)
CD  A 981 (-3.4A)
CD  A 981 (-3.4A)
 0.22A 3hy7B-1kugA:
26.9		 3hy7B-1kugA:
29.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_A_HAEA272_1
(COLLAGENASE 3)		 1kug METALLOPROTEINASE
(Protobothrops
mucrosquamatus) 		4 / 5 HIS A 144
GLU A 145
HIS A 148
HIS A 154
 CD  A 981 (-3.5A)
CD  A 981 ( 4.6A)
CD  A 981 (-3.4A)
CD  A 981 (-3.4A)
 0.25A 3kecA-1kugA:
10.7		 3kecA-1kugA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		 1kug METALLOPROTEINASE
(Protobothrops
mucrosquamatus) 		3 / 3 HIS A 144
GLU A 145
HIS A 148
 CD  A 981 (-3.5A)
CD  A 981 ( 4.6A)
CD  A 981 (-3.4A)
 0.19A 3kecB-1kugA:
10.6		 3kecB-1kugA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LIK_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		 1kug METALLOPROTEINASE
(Protobothrops
mucrosquamatus) 		4 / 5 HIS A 144
GLU A 145
HIS A 148
HIS A 154
 CD  A 981 (-3.5A)
CD  A 981 ( 4.6A)
CD  A 981 (-3.4A)
CD  A 981 (-3.4A)
 0.21A 3likA-1kugA:
11.1		 3likA-1kugA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LIL_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		 1kug METALLOPROTEINASE
(Protobothrops
mucrosquamatus) 		4 / 4 HIS A 144
GLU A 145
HIS A 148
HIS A 154
 CD  A 981 (-3.5A)
CD  A 981 ( 4.6A)
CD  A 981 (-3.4A)
CD  A 981 (-3.4A)
 0.21A 3lilA-1kugA:
11.1		 3lilA-1kugA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LJG_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 1kug METALLOPROTEINASE
(Protobothrops
mucrosquamatus) 		4 / 5 HIS A 144
GLU A 145
HIS A 148
HIS A 154
 CD  A 981 (-3.5A)
CD  A 981 ( 4.6A)
CD  A 981 (-3.4A)
CD  A 981 (-3.4A)
 0.18A 3ljgA-1kugA:
11.2		 3ljgA-1kugA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LKA_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		 1kug METALLOPROTEINASE
(Protobothrops
mucrosquamatus) 		4 / 5 HIS A 144
GLU A 145
HIS A 148
HIS A 154
 CD  A 981 (-3.5A)
CD  A 981 ( 4.6A)
CD  A 981 (-3.4A)
CD  A 981 (-3.4A)
 0.22A 3lkaA-1kugA:
11.1		 3lkaA-1kugA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UT5_B_LOCB502_1
(TUBULIN BETA CHAIN)		 1kug METALLOPROTEINASE
(Protobothrops
mucrosquamatus) 		5 / 12 CYH A  46
LEU A  49
LEU A 150
MET A 118
ILE A  53
 None
 1.16A 3ut5B-1kugA:
undetectable		 3ut5B-1kugA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UT5_D_LOCD502_1
(TUBULIN BETA CHAIN)		 1kug METALLOPROTEINASE
(Protobothrops
mucrosquamatus) 		5 / 12 CYH A  46
LEU A  49
LEU A 150
MET A 118
ILE A 199
 None
 1.17A 3ut5D-1kugA:
undetectable		 3ut5D-1kugA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_N_CUN604_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1kug METALLOPROTEINASE
(Protobothrops
mucrosquamatus) 		3 / 3 HIS A 154
HIS A 148
HIS A 144
 CD  A 981 (-3.4A)
CD  A 981 (-3.4A)
CD  A 981 (-3.5A)
 0.73A 3x2qN-1kugA:
0.0		 3x2qN-1kugA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		 1kug METALLOPROTEINASE
(Protobothrops
mucrosquamatus) 		4 / 6 HIS A 144
GLU A 145
HIS A 148
HIS A 154
 CD  A 981 (-3.5A)
CD  A 981 ( 4.6A)
CD  A 981 (-3.4A)
CD  A 981 (-3.4A)
 0.37A 4a7bA-1kugA:
10.4		 4a7bA-1kugA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AF0_B_MOAB1526_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1kug METALLOPROTEINASE
(Protobothrops
mucrosquamatus) 		5 / 10 SER A  25
SER A  26
ASN A  27
MET A  20
GLY A  19
 None
 1.42A 4af0B-1kugA:
undetectable		 4af0B-1kugA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_D_LOCD502_1
(TUBULIN BETA CHAIN)		 1kug METALLOPROTEINASE
(Protobothrops
mucrosquamatus) 		5 / 12 CYH A  46
LEU A  49
LEU A 150
MET A 118
ILE A 199
 None
 1.11A 4x1iD-1kugA:
undetectable		 4x1iD-1kugA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1Y_D_LOCD502_2
(TUBULIN BETA CHAIN)		 1kug METALLOPROTEINASE
(Protobothrops
mucrosquamatus) 		5 / 12 CYH A  46
LEU A  49
LEU A 150
MET A 118
ILE A 199
 None
 1.06A 4x1yD-1kugA:
undetectable		 4x1yD-1kugA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1kug METALLOPROTEINASE
(Protobothrops
mucrosquamatus) 		3 / 3 HIS A 154
HIS A 148
HIS A 144
 CD  A 981 (-3.4A)
CD  A 981 (-3.4A)
CD  A 981 (-3.5A)
 0.73A 5b1bA-1kugA:
0.0		 5b1bA-1kugA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1kug METALLOPROTEINASE
(Protobothrops
mucrosquamatus) 		3 / 3 HIS A 154
HIS A 148
HIS A 144
 CD  A 981 (-3.4A)
CD  A 981 (-3.4A)
CD  A 981 (-3.5A)
 0.75A 5b1bN-1kugA:
0.0		 5b1bN-1kugA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5J_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		 1kug METALLOPROTEINASE
(Protobothrops
mucrosquamatus) 		4 / 4 HIS A 144
GLU A 145
HIS A 148
HIS A 154
 CD  A 981 (-3.5A)
CD  A 981 ( 4.6A)
CD  A 981 (-3.4A)
CD  A 981 (-3.4A)
 0.20A 5n5jA-1kugA:
11.1		 5n5jA-1kugA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5K_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		 1kug METALLOPROTEINASE
(Protobothrops
mucrosquamatus) 		4 / 5 HIS A 144
GLU A 145
HIS A 148
HIS A 154
 CD  A 981 (-3.5A)
CD  A 981 ( 4.6A)
CD  A 981 (-3.4A)
CD  A 981 (-3.4A)
 0.24A 5n5kA-1kugA:
11.2		 5n5kA-1kugA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NR3_A_95EA401_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3B)		 1kug METALLOPROTEINASE
(Protobothrops
mucrosquamatus) 		4 / 7 ILE A  67
PHE A  80
TRP A  61
ASP A  59
 None
 1.40A 5nr3A-1kugA:
0.0		 5nr3A-1kugA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1kug METALLOPROTEINASE
(Protobothrops
mucrosquamatus) 		3 / 3 HIS A 154
HIS A 148
HIS A 144
 CD  A 981 (-3.4A)
CD  A 981 (-3.4A)
CD  A 981 (-3.5A)
 0.72A 5w97a-1kugA:
0.0		 5w97a-1kugA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1kug METALLOPROTEINASE
(Protobothrops
mucrosquamatus) 		3 / 3 HIS A 154
HIS A 148
HIS A 144
 CD  A 981 (-3.4A)
CD  A 981 (-3.4A)
CD  A 981 (-3.5A)
 0.72A 5x19N-1kugA:
undetectable		 5x19N-1kugA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1kug METALLOPROTEINASE
(Protobothrops
mucrosquamatus) 		3 / 3 HIS A 154
HIS A 148
HIS A 144
 CD  A 981 (-3.4A)
CD  A 981 (-3.4A)
CD  A 981 (-3.5A)
 0.70A 5x1bN-1kugA:
0.0		 5x1bN-1kugA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1kug METALLOPROTEINASE
(Protobothrops
mucrosquamatus) 		3 / 3 HIS A 154
HIS A 148
HIS A 144
 CD  A 981 (-3.4A)
CD  A 981 (-3.4A)
CD  A 981 (-3.5A)
 0.67A 5x1fN-1kugA:
undetectable		 5x1fN-1kugA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Y_D_9CRD501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1kug METALLOPROTEINASE
(Protobothrops
mucrosquamatus) 		3 / 3 ASN A 104
VAL A 138
HIS A 131
 None
None
CD  A 988 (-3.3A)
 0.86A 6a5yD-1kugA:
0.0		 6a5yD-1kugA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_A_ADNA602_1
(LYSINE--TRNA LIGASE)		 1kug METALLOPROTEINASE
(Protobothrops
mucrosquamatus) 		5 / 10 ASN A 149
GLU A 145
HIS A 144
GLU A 153
ILE A 166
 None
CD  A 981 ( 4.6A)
CD  A 981 (-3.5A)
None
None
 1.13A 6bniA-1kugA:
undetectable		 6bniA-1kugA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_B_ADNB602_1
(LYSINE--TRNA LIGASE)		 1kug METALLOPROTEINASE
(Protobothrops
mucrosquamatus) 		5 / 10 ASN A 149
GLU A 145
HIS A 144
GLU A 153
ILE A 166
 None
CD  A 981 ( 4.6A)
CD  A 981 (-3.5A)
None
None
 1.13A 6bniB-1kugA:
undetectable		 6bniB-1kugA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_B_ACTB804_0
(UNCHARACTERIZED
PROTEIN)		 1kug METALLOPROTEINASE
(Protobothrops
mucrosquamatus) 		4 / 4 HIS A  94
VAL A  15
LEU A  88
ALA A  97
 None
 1.38A 6d8pB-1kugA:
0.0		 6d8pB-1kugA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1kug METALLOPROTEINASE
(Protobothrops
mucrosquamatus) 		3 / 3 HIS A 154
HIS A 148
HIS A 144
 CD  A 981 (-3.4A)
CD  A 981 (-3.4A)
CD  A 981 (-3.5A)
 0.73A 6nmfN-1kugA:
0.0		 6nmfN-1kugA:
15.80