SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1kut'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XR2_B_C2FB1201_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 1kut PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE
(Thermotoga
maritima) 		4 / 8 LYS A 170
THR A  71
SER A 188
GLU A 172
 None
 1.29A 1xr2B-1kutA:
0.0		 1xr2B-1kutA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 1kut PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE
(Thermotoga
maritima) 		5 / 12 CYH A  43
THR A  46
THR A  47
LYS A 170
LEU A  72
 None
 1.19A 3gwxB-1kutA:
0.0		 3gwxB-1kutA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1kut PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE
(Thermotoga
maritima) 		5 / 7 PHE A 113
VAL A  84
VAL A  86
LEU A 110
VAL A 108
 None
 1.40A 3hs6B-1kutA:
undetectable		 3hs6B-1kutA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK7_B_SAMB770_0
(23S RRNA
METHYLTRANSFERASE)		 1kut PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE
(Thermotoga
maritima) 		5 / 12 LEU A 183
PHE A 173
GLY A 174
ILE A  59
VAL A 181
 None
 1.00A 3nk7B-1kutA:
undetectable		 3nk7B-1kutA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_B_017B200_1
(FIV PROTEASE)		 1kut PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE
(Thermotoga
maritima) 		5 / 10 LEU A  19
ALA A  44
ILE A 187
VAL A  74
LEU A  72
 None
 1.00A 3ogpA-1kutA:
undetectable		 3ogpA-1kutA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_B_DXCB92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1kut PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE
(Thermotoga
maritima) 		4 / 5 VAL A  85
VAL A 111
ARG A  87
LYS A 156
 None
 1.44A 3rv5A-1kutA:
undetectable
3rv5B-1kutA:
undetectable		 3rv5A-1kutA:
17.26
3rv5B-1kutA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_B_BQ1B1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 1kut PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE
(Thermotoga
maritima) 		4 / 8 ALA A 147
ALA A 148
ILE A 151
TYR A 171
 None
 0.56A 4v1fA-1kutA:
undetectable
4v1fB-1kutA:
undetectable		 4v1fA-1kutA:
17.83
4v1fB-1kutA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1344_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1kut PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE
(Thermotoga
maritima) 		4 / 5 GLU A 186
LYS A   8
ASP A 185
GLU A 172
 None
 1.42A 5a06A-1kutA:
undetectable		 5a06A-1kutA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_A_REAA602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 1kut PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE
(Thermotoga
maritima) 		5 / 12 ARG A 193
PHE A 159
LEU A 166
CYH A 224
THR A  46
 None
 1.33A 5fhzA-1kutA:
undetectable		 5fhzA-1kutA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYF_B_TA1B502_1
(TUBULIN BETA CHAIN)		 1kut PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE
(Thermotoga
maritima) 		5 / 12 ASP A 185
LEU A  88
ASP A 168
ALA A 148
LEU A  54
 None
 1.43A 5syfB-1kutA:
undetectable		 5syfB-1kutA:
19.11