SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1kuu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VIF_A_FOLA1_0
(DIHYDROFOLATE
REDUCTASE)		 1kuu CONSERVED PROTEIN
(Methanothermobac
ter) 		3 / 3 GLN A 150
ILE A 145
TYR A 144
 None
 0.65A 1vifA-1kuuA:
undetectable		 1vifA-1kuuA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA501_1
(CYTOCHROME P450 2C8)		 1kuu CONSERVED PROTEIN
(Methanothermobac
ter) 		5 / 11 GLY A  10
ILE A 170
ALA A 185
THR A  32
ILE A  62
 None
 0.94A 2nnhA-1kuuA:
undetectable		 2nnhA-1kuuA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB501_1
(CYTOCHROME P450 2C8)		 1kuu CONSERVED PROTEIN
(Methanothermobac
ter) 		5 / 9 GLY A  10
ILE A 170
THR A  32
ILE A  62
VAL A  39
 None
 1.17A 2nnhB-1kuuA:
undetectable		 2nnhB-1kuuA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNJ_A_225A501_1
(CYTOCHROME P450 2C8)		 1kuu CONSERVED PROTEIN
(Methanothermobac
ter) 		5 / 10 ILE A 170
ALA A 185
THR A  32
ILE A  62
VAL A  39
 None
 1.08A 2nnjA-1kuuA:
undetectable		 2nnjA-1kuuA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EIG_A_MTXA200_2
(DIHYDROFOLATE
REDUCTASE)		 1kuu CONSERVED PROTEIN
(Methanothermobac
ter) 		4 / 5 ARG A   5
ILE A 113
VAL A  71
THR A  32
 None
 1.24A 3eigA-1kuuA:
undetectable		 3eigA-1kuuA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_1
(GENOME POLYPROTEIN)		 1kuu CONSERVED PROTEIN
(Methanothermobac
ter) 		5 / 12 GLY A 119
GLY A  10
SER A  16
ALA A 188
ALA A 187
 None
 1.01A 3keeB-1kuuA:
undetectable		 3keeB-1kuuA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_C_30BC500_1
(GENOME POLYPROTEIN)		 1kuu CONSERVED PROTEIN
(Methanothermobac
ter) 		5 / 12 GLY A 119
GLY A  10
SER A  16
ALA A 188
ALA A 187
 None
 1.05A 3keeC-1kuuA:
undetectable		 3keeC-1kuuA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R55_A_PZAA598_0
(LACTOPEROXIDASE)		 1kuu CONSERVED PROTEIN
(Methanothermobac
ter) 		3 / 3 GLU A 175
PHE A 179
GLN A 150
 None
 0.82A 3r55A-1kuuA:
undetectable		 3r55A-1kuuA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1kuu CONSERVED PROTEIN
(Methanothermobac
ter) 		5 / 12 GLY A 119
GLY A  10
SER A  16
ALA A 188
ALA A 187
 None
 1.15A 3sueB-1kuuA:
undetectable		 3sueB-1kuuA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1kuu CONSERVED PROTEIN
(Methanothermobac
ter) 		5 / 12 GLY A 119
GLY A  10
SER A  16
ALA A 188
ALA A 187
 None
 1.06A 3sufA-1kuuA:
undetectable		 3sufA-1kuuA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HGC_A_HCYA501_1
(SERPIN)		 1kuu CONSERVED PROTEIN
(Methanothermobac
ter) 		5 / 12 ALA A 187
THR A 156
PHE A 176
ILE A 170
PHE A 158
 None
 1.34A 5hgcA-1kuuA:
0.7		 5hgcA-1kuuA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGZ_A_SPRA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 1kuu CONSERVED PROTEIN
(Methanothermobac
ter) 		5 / 9 LEU A  98
ILE A  80
ILE A 145
GLU A 152
GLU A 104
 None
 1.38A 5igzA-1kuuA:
undetectable		 5igzA-1kuuA:
19.93