SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1kvk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AQ7_B_AG2B4_1
(TRYPSIN
AERUGINOSIN 98-B)		 1kvk MEVALONATE KINASE
(Rattus
norvegicus) 		4 / 8 SER A 208
SER A 150
GLY A 144
GLY A  12
 None
None
ATP  A 535 ( 3.2A)
None
 0.71A 1aq7A-1kvkA:
undetectable		 1aq7A-1kvkA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FO4_B_SALB4005_1
(XANTHINE
DEHYDROGENASE)		 1kvk MEVALONATE KINASE
(Rattus
norvegicus) 		4 / 7 SER A 314
THR A 237
VAL A 239
ALA A 334
 None
 1.11A 1fo4B-1kvkA:
undetectable		 1fo4B-1kvkA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1503_0
(FERROCHELATASE)		 1kvk MEVALONATE KINASE
(Rattus
norvegicus) 		3 / 3 LEU A 137
PRO A 138
LEU A 143
 None
 0.48A 1hrkA-1kvkA:
undetectable		 1hrkA-1kvkA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_D_SAMD200_0
(METHIONINE REPRESSOR)		 1kvk MEVALONATE KINASE
(Rattus
norvegicus) 		5 / 12 ALA A 213
GLY A 211
LEU A  16
LEU A 227
PRO A 228
 None
 1.06A 1mjqC-1kvkA:
undetectable
1mjqD-1kvkA:
undetectable		 1mjqC-1kvkA:
12.34
1mjqD-1kvkA:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_J_SAMJ200_0
(METHIONINE REPRESSOR)		 1kvk MEVALONATE KINASE
(Rattus
norvegicus) 		5 / 12 ALA A 213
GLY A 211
LEU A  16
LEU A 227
PRO A 228
 None
 1.06A 1mjqI-1kvkA:
undetectable
1mjqJ-1kvkA:
undetectable		 1mjqI-1kvkA:
12.34
1mjqJ-1kvkA:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		 1kvk MEVALONATE KINASE
(Rattus
norvegicus) 		5 / 12 HIS A 197
LEU A 137
GLY A 140
ALA A 147
ALA A 148
 MG  A 536 ( 4.3A)
None
ATP  A 535 (-2.8A)
MG  A 536 (-3.9A)
None
 1.00A 2oc8A-1kvkA:
undetectable		 2oc8A-1kvkA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1kvk MEVALONATE KINASE
(Rattus
norvegicus) 		3 / 3 LEU A 137
PRO A 138
LEU A 143
 None
 0.62A 2po5B-1kvkA:
undetectable		 2po5B-1kvkA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1kvk MEVALONATE KINASE
(Rattus
norvegicus) 		3 / 3 LEU A 137
PRO A 138
LEU A 143
 None
 0.56A 2po7B-1kvkA:
undetectable		 2po7B-1kvkA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RXF_A_4APA9_1
(CATIONIC TRYPSIN)		 1kvk MEVALONATE KINASE
(Rattus
norvegicus) 		4 / 6 SER A 208
SER A 150
GLY A 144
GLY A  12
 None
None
ATP  A 535 ( 3.2A)
None
 0.71A 3rxfA-1kvkA:
undetectable		 3rxfA-1kvkA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1kvk MEVALONATE KINASE
(Rattus
norvegicus) 		5 / 12 HIS A 197
LEU A 137
GLY A 140
ALA A 147
ALA A 148
 MG  A 536 ( 4.3A)
None
ATP  A 535 (-2.8A)
MG  A 536 (-3.9A)
None
 0.89A 3sufA-1kvkA:
undetectable		 3sufA-1kvkA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1kvk MEVALONATE KINASE
(Rattus
norvegicus) 		3 / 3 LEU A 137
PRO A 138
LEU A 143
 None
 0.46A 3w1wB-1kvkA:
undetectable		 3w1wB-1kvkA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CCQ_A_ACTA1317_0
(THIOREDOXIN
REDUCTASE)		 1kvk MEVALONATE KINASE
(Rattus
norvegicus) 		3 / 3 LEU A 327
GLU A 295
SER A 329
 None
 0.67A 4ccqA-1kvkA:
undetectable		 4ccqA-1kvkA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP3_B_RBTB1129_1
(B-CELL LYMPHOMA 6
PROTEIN)		 1kvk MEVALONATE KINASE
(Rattus
norvegicus) 		4 / 7 ASN A 236
LEU A 234
GLY A 140
SER A 145
 None
None
ATP  A 535 (-2.8A)
ATP  A 535 (-2.9A)
 0.85A 4cp3A-1kvkA:
0.0
4cp3B-1kvkA:
0.0		 4cp3A-1kvkA:
16.62
4cp3B-1kvkA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_B_ADNB401_2
(ADENOSINE KINASE)		 1kvk MEVALONATE KINASE
(Rattus
norvegicus) 		4 / 5 LEU A  35
SER A 145
LEU A 234
ASN A  55
 None
ATP  A 535 (-2.9A)
None
ATP  A 535 (-4.0A)
 1.02A 4n09B-1kvkA:
undetectable		 4n09B-1kvkA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA603_1
(SERUM ALBUMIN)		 1kvk MEVALONATE KINASE
(Rattus
norvegicus) 		5 / 11 LEU A 157
ARG A 121
LEU A 126
LEU A 115
LEU A 129
 None
 1.35A 4or0A-1kvkA:
2.1		 4or0A-1kvkA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_0
(HYDG PROTEIN)		 1kvk MEVALONATE KINASE
(Rattus
norvegicus) 		5 / 12 VAL A  31
LEU A 234
LEU A 331
LEU A 305
ALA A  21
 None
 1.43A 4rtbA-1kvkA:
undetectable		 4rtbA-1kvkA:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_D_29SD601_2
(ESTROGEN RECEPTOR)		 1kvk MEVALONATE KINASE
(Rattus
norvegicus) 		3 / 3 LEU A 294
ASP A 299
ILE A 372
 None
 0.58A 4xi3D-1kvkA:
undetectable		 4xi3D-1kvkA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1kvk MEVALONATE KINASE
(Rattus
norvegicus) 		4 / 7 SER A 222
ARG A 277
GLY A 280
GLU A 281
 None
 0.91A 5btaA-1kvkA:
1.9
5btaC-1kvkA:
1.1
5btaD-1kvkA:
undetectable		 5btaA-1kvkA:
21.55
5btaC-1kvkA:
21.55
5btaD-1kvkA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 1kvk MEVALONATE KINASE
(Rattus
norvegicus) 		4 / 6 SER A 222
ARG A 277
GLY A 280
GLU A 281
 None
 0.87A 5btaA-1kvkA:
1.9
5btaB-1kvkA:
undetectable
5btaC-1kvkA:
0.5		 5btaA-1kvkA:
21.55
5btaB-1kvkA:
21.99
5btaC-1kvkA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1kvk MEVALONATE KINASE
(Rattus
norvegicus) 		4 / 6 SER A 222
ARG A 277
GLY A 280
GLU A 281
 None
 0.93A 5btcA-1kvkA:
1.8
5btcC-1kvkA:
1.3
5btcD-1kvkA:
undetectable		 5btcA-1kvkA:
21.55
5btcC-1kvkA:
21.55
5btcD-1kvkA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1kvk MEVALONATE KINASE
(Rattus
norvegicus) 		4 / 6 SER A 222
ARG A 277
GLY A 280
GLU A 281
 None
 0.87A 5btcA-1kvkA:
1.8
5btcB-1kvkA:
undetectable
5btcC-1kvkA:
1.3		 5btcA-1kvkA:
21.55
5btcB-1kvkA:
21.99
5btcC-1kvkA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_F_GFNF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1kvk MEVALONATE KINASE
(Rattus
norvegicus) 		4 / 7 SER A 222
ARG A 277
GLY A 280
GLU A 281
 None
 0.85A 5btfA-1kvkA:
0.1
5btfB-1kvkA:
undetectable
5btfC-1kvkA:
0.0		 5btfA-1kvkA:
21.55
5btfB-1kvkA:
21.99
5btfC-1kvkA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1kvk MEVALONATE KINASE
(Rattus
norvegicus) 		4 / 5 SER A 222
ARG A 277
GLY A 280
GLU A 281
 None
 1.16A 5btiC-1kvkA:
1.8
5btiD-1kvkA:
undetectable		 5btiC-1kvkA:
21.55
5btiD-1kvkA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EML_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 1kvk MEVALONATE KINASE
(Rattus
norvegicus) 		5 / 12 LEU A 273
GLY A 280
PRO A 228
LEU A 227
LEU A  29
 None
 1.31A 5emlA-1kvkA:
undetectable		 5emlA-1kvkA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EML_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 1kvk MEVALONATE KINASE
(Rattus
norvegicus) 		5 / 12 PRO A 138
LEU A 137
GLY A 338
LEU A 318
LEU A 234
 None
 0.97A 5emlA-1kvkA:
undetectable		 5emlA-1kvkA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HSW_A_ACTA501_0
(ORF 37)		 1kvk MEVALONATE KINASE
(Rattus
norvegicus) 		4 / 5 ARG A  36
SER A   9
SER A 378
SER A 208
 None
 1.39A 5hswA-1kvkA:
0.0		 5hswA-1kvkA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC607_0
(ALPHA-AMYLASE)		 1kvk MEVALONATE KINASE
(Rattus
norvegicus) 		5 / 6 GLY A  12
ASP A 204
GLY A 376
PRO A 375
GLY A 211
 None
ATP  A 535 ( 3.8A)
None
None
None
 1.24A 6ag0C-1kvkA:
undetectable		 6ag0C-1kvkA:
12.02