SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1kw2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1J78_B_VDYB500_1
(VITAMIN D BINDING
PROTEIN)		 1kw2 VITAMIN D-BINDING
PROTEIN
(Homo
sapiens) 		9 / 10 GLU A  24
VAL A  28
PHE A  40
LEU A  47
TYR A  48
LEU A  63
TYR A  84
SER A  92
MET A 123
 None
 0.44A 1j78B-1kw2A:
51.4		 1j78B-1kw2A:
99.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1J78_B_VDYB500_1
(VITAMIN D BINDING
PROTEIN)		 1kw2 VITAMIN D-BINDING
PROTEIN
(Homo
sapiens) 		6 / 10 GLU A  24
VAL A  28
PHE A  40
TYR A  48
LYS A  51
TYR A  84
 None
 1.11A 1j78B-1kw2A:
51.4		 1j78B-1kw2A:
99.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_B_AG2B7011_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 1kw2 VITAMIN D-BINDING
PROTEIN
(Homo
sapiens) 		4 / 5 GLU A 249
ARG A 232
LEU A 248
ASP A 344
 None
 1.27A 1n13B-1kw2A:
undetectable
1n13C-1kw2A:
undetectable		 1n13B-1kw2A:
13.79
1n13C-1kw2A:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_2
(THYROID HORMONE
RECEPTOR BETA-1)		 1kw2 VITAMIN D-BINDING
PROTEIN
(Homo
sapiens) 		4 / 5 ILE A 261
SER A 234
ARG A 232
LEU A 262
 None
 1.20A 1y0xX-1kw2A:
0.6		 1y0xX-1kw2A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_C_BEZC1222_0
(PEROXIREDOXIN 6)		 1kw2 VITAMIN D-BINDING
PROTEIN
(Homo
sapiens) 		4 / 8 PRO A 171
THR A 213
SER A 216
GLU A 271
 None
 0.92A 2v32C-1kw2A:
undetectable
2v32D-1kw2A:
undetectable		 2v32C-1kw2A:
19.53
2v32D-1kw2A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_C_BEZC1218_0
(PEROXIREDOXIN 6.)		 1kw2 VITAMIN D-BINDING
PROTEIN
(Homo
sapiens) 		4 / 8 PRO A 171
THR A 213
SER A 216
GLU A 271
 None
 0.99A 2v41C-1kw2A:
undetectable
2v41D-1kw2A:
undetectable		 2v41C-1kw2A:
19.53
2v41D-1kw2A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_D_BEZD1222_0
(PEROXIREDOXIN 6.)		 1kw2 VITAMIN D-BINDING
PROTEIN
(Homo
sapiens) 		4 / 8 PRO A 171
THR A 213
SER A 216
GLU A 271
 None
 0.95A 2v41C-1kw2A:
undetectable
2v41D-1kw2A:
undetectable		 2v41C-1kw2A:
19.53
2v41D-1kw2A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_H_BEZH1222_0
(PEROXIREDOXIN 6.)		 1kw2 VITAMIN D-BINDING
PROTEIN
(Homo
sapiens) 		4 / 8 PRO A 171
THR A 213
SER A 216
GLU A 271
 None
 0.99A 2v41G-1kw2A:
undetectable
2v41H-1kw2A:
undetectable		 2v41G-1kw2A:
19.53
2v41H-1kw2A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_D_2FAD500_2
(ADENOSYLHOMOCYSTEINA
SE)		 1kw2 VITAMIN D-BINDING
PROTEIN
(Homo
sapiens) 		4 / 4 LEU A 350
GLN A 404
THR A 354
THR A 368
 None
 1.02A 2zj0D-1kw2A:
undetectable		 2zj0D-1kw2A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_A_BEZA302_0
(DISULFIDE
INTERCHANGE PROTEIN)		 1kw2 VITAMIN D-BINDING
PROTEIN
(Homo
sapiens) 		4 / 6 HIS A 208
LEU A 212
LYS A 276
PRO A 279
 None
 1.05A 3gv1A-1kw2A:
0.0
3gv1C-1kw2A:
undetectable		 3gv1A-1kw2A:
15.65
3gv1C-1kw2A:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB301_0
(DISULFIDE
INTERCHANGE PROTEIN)		 1kw2 VITAMIN D-BINDING
PROTEIN
(Homo
sapiens) 		4 / 6 LEU A 212
LYS A 276
PRO A 279
HIS A 208
 None
 1.07A 3gv1A-1kw2A:
0.0
3gv1B-1kw2A:
0.0		 3gv1A-1kw2A:
15.65
3gv1B-1kw2A:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M7R_A_VDXA425_1
(VITAMIN D3 RECEPTOR)		 1kw2 VITAMIN D-BINDING
PROTEIN
(Homo
sapiens) 		5 / 12 LEU A 361
VAL A 359
SER A 457
SER A 411
LEU A 470
 None
 1.32A 3m7rA-1kw2A:
1.0		 3m7rA-1kw2A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1Y_A_RBFA1176_1
(PUTATIVE PROTEASE I)		 1kw2 VITAMIN D-BINDING
PROTEIN
(Homo
sapiens) 		4 / 8 GLN A 222
ASN A 456
ASN A 217
THR A 214
 None
 1.31A 4d1yA-1kw2A:
undetectable
4d1yB-1kw2A:
undetectable		 4d1yA-1kw2A:
18.52
4d1yB-1kw2A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_A_BEZA502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 1kw2 VITAMIN D-BINDING
PROTEIN
(Homo
sapiens) 		4 / 6 PHE A 385
VAL A 342
LEU A 369
LEU A 372
 None
 0.80A 6e43A-1kw2A:
0.8		 6e43A-1kw2A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_B_BEZB502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 1kw2 VITAMIN D-BINDING
PROTEIN
(Homo
sapiens) 		4 / 6 PHE A 385
VAL A 342
LEU A 369
LEU A 372
 None
 0.83A 6e43B-1kw2A:
0.0		 6e43B-1kw2A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_C_BEZC502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 1kw2 VITAMIN D-BINDING
PROTEIN
(Homo
sapiens) 		4 / 6 PHE A 385
VAL A 342
LEU A 369
LEU A 372
 None
 0.82A 6e43C-1kw2A:
0.0		 6e43C-1kw2A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_D_BEZD502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 1kw2 VITAMIN D-BINDING
PROTEIN
(Homo
sapiens) 		4 / 6 PHE A 385
VAL A 342
LEU A 369
LEU A 372
 None
 0.92A 6e43D-1kw2A:
0.0		 6e43D-1kw2A:
21.02