SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1kwc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_1
(ADENOSINE DEAMINASE)		 1kwc 2,3-DIHYDROXYBIPHENY
L DIOXYGENASE
(Pseudomonas
sp.
KKS102) 		5 / 12 HIS B 194
ALA B 145
GLY B 144
HIS B 209
ASP B 243
 BPY  B 401 (-4.3A)
None
None
BPY  B 401 (-3.7A)
BPY  B 401 (-3.9A)
 1.37A 1a4lD-1kwcB:
undetectable		 1a4lD-1kwcB:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4S_A_TPVA201_2
(PROTEIN (HIV-1
PROTEASE))		 1kwc 2,3-DIHYDROXYBIPHENY
L DIOXYGENASE
(Pseudomonas
sp.
KKS102) 		4 / 8 LEU B  79
GLY B 110
PHE B  86
VAL B  84
 None
 0.68A 1d4sB-1kwcB:
undetectable		 1d4sB-1kwcB:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIP_A_KTNA801_1
(CYTOCHROME P450
107A1)		 1kwc 2,3-DIHYDROXYBIPHENY
L DIOXYGENASE
(Pseudomonas
sp.
KKS102) 		5 / 12 PHE B  10
ALA B  50
GLY B   6
ALA B 120
LEU B  39
 None
 1.19A 1jipA-1kwcB:
0.6		 1jipA-1kwcB:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9U_A_CPFA5002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 1kwc 2,3-DIHYDROXYBIPHENY
L DIOXYGENASE
(Pseudomonas
sp.
KKS102) 		4 / 6 PHE B 136
ASN B 215
ARG B 192
GLN B 141
 None
 1.34A 1t9uA-1kwcB:
0.0		 1t9uA-1kwcB:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LBD_A_REAA500_1
(RETINOIC ACID
RECEPTOR GAMMA)		 1kwc 2,3-DIHYDROXYBIPHENY
L DIOXYGENASE
(Pseudomonas
sp.
KKS102) 		5 / 12 LEU B 227
ARG B 232
ILE B 233
GLY B 221
LEU B 246
 None
 1.30A 2lbdA-1kwcB:
undetectable		 2lbdA-1kwcB:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_1
(ESTROGEN RECEPTOR)		 1kwc 2,3-DIHYDROXYBIPHENY
L DIOXYGENASE
(Pseudomonas
sp.
KKS102) 		4 / 6 ALA B  69
ASP B  68
GLU B  73
ARG B  88
 None
 1.44A 2ouzA-1kwcB:
undetectable		 2ouzA-1kwcB:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1500_1
(CYTOCHROME P450 3A4)		 1kwc 2,3-DIHYDROXYBIPHENY
L DIOXYGENASE
(Pseudomonas
sp.
KKS102) 		5 / 11 SER B 254
LEU B   8
ILE B 257
PHE B 210
LEU B  22
 None
 1.43A 2v0mA-1kwcB:
0.9		 2v0mA-1kwcB:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_A_FFOA505_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1kwc 2,3-DIHYDROXYBIPHENY
L DIOXYGENASE
(Pseudomonas
sp.
KKS102) 		5 / 12 LEU B  64
GLY B   6
LEU B 113
SER B   1
GLY B 165
 None
 1.38A 2vmyB-1kwcB:
undetectable		 2vmyB-1kwcB:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A25_A_SAMA279_1
(UNCHARACTERIZED
PROTEIN PH0793)		 1kwc 2,3-DIHYDROXYBIPHENY
L DIOXYGENASE
(Pseudomonas
sp.
KKS102) 		3 / 3 MET B 100
GLU B  65
ASP B 140
 None
 1.09A 3a25A-1kwcB:
undetectable		 3a25A-1kwcB:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		 1kwc 2,3-DIHYDROXYBIPHENY
L DIOXYGENASE
(Pseudomonas
sp.
KKS102) 		4 / 8 LEU B 164
ALA B  76
LEU B  79
TYR B 116
 None
 0.88A 3cldB-1kwcB:
undetectable		 3cldB-1kwcB:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LS4_H_TCIH220_2
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT
LIGHT CHAIN OF
ANTIBODY FAB
FRAGMENT)		 1kwc 2,3-DIHYDROXYBIPHENY
L DIOXYGENASE
(Pseudomonas
sp.
KKS102) 		4 / 5 TYR B 160
ILE B 143
LEU B   5
PHE B 166
 None
 1.00A 3ls4L-1kwcB:
undetectable		 3ls4L-1kwcB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_A_PFLA319_1
(GLR4197 PROTEIN)		 1kwc 2,3-DIHYDROXYBIPHENY
L DIOXYGENASE
(Pseudomonas
sp.
KKS102) 		4 / 7 ILE B   2
LEU B 164
THR B 195
ILE B 196
 None
 0.90A 3p50A-1kwcB:
undetectable		 3p50A-1kwcB:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_B_PFLB319_1
(GLR4197 PROTEIN)		 1kwc 2,3-DIHYDROXYBIPHENY
L DIOXYGENASE
(Pseudomonas
sp.
KKS102) 		4 / 7 ILE B   2
LEU B 164
THR B 195
ILE B 196
 None
 0.91A 3p50B-1kwcB:
undetectable		 3p50B-1kwcB:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_C_PFLC319_1
(GLR4197 PROTEIN)		 1kwc 2,3-DIHYDROXYBIPHENY
L DIOXYGENASE
(Pseudomonas
sp.
KKS102) 		4 / 7 ILE B   2
LEU B 164
THR B 195
ILE B 196
 None
 0.90A 3p50C-1kwcB:
undetectable		 3p50C-1kwcB:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_D_PFLD320_1
(GLR4197 PROTEIN)		 1kwc 2,3-DIHYDROXYBIPHENY
L DIOXYGENASE
(Pseudomonas
sp.
KKS102) 		4 / 7 ILE B   2
LEU B 164
THR B 195
ILE B 196
 None
 0.91A 3p50D-1kwcB:
undetectable		 3p50D-1kwcB:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_E_PFLE319_1
(GLR4197 PROTEIN)		 1kwc 2,3-DIHYDROXYBIPHENY
L DIOXYGENASE
(Pseudomonas
sp.
KKS102) 		4 / 7 ILE B   2
LEU B 164
THR B 195
ILE B 196
 None
 0.92A 3p50E-1kwcB:
undetectable		 3p50E-1kwcB:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_B_CVIB301_0
(PUTATIVE REGULATORY
PROTEIN)		 1kwc 2,3-DIHYDROXYBIPHENY
L DIOXYGENASE
(Pseudomonas
sp.
KKS102) 		5 / 12 LEU B   8
ILE B 143
ALA B  42
LEU B 212
LEU B 227
 None
 1.03A 3vw1B-1kwcB:
0.0		 3vw1B-1kwcB:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_B_CVIB301_0
(PUTATIVE REGULATORY
PROTEIN)		 1kwc 2,3-DIHYDROXYBIPHENY
L DIOXYGENASE
(Pseudomonas
sp.
KKS102) 		5 / 12 LEU B   8
ILE B 257
ILE B 143
ALA B  42
LEU B 212
 None
 1.08A 3vw1B-1kwcB:
0.0		 3vw1B-1kwcB:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_A_ADNA401_2
(ADENOSINE KINASE)		 1kwc 2,3-DIHYDROXYBIPHENY
L DIOXYGENASE
(Pseudomonas
sp.
KKS102) 		4 / 4 LEU B   5
ILE B  49
GLY B 144
PHE B 210
 None
 0.81A 4dc3A-1kwcB:
undetectable		 4dc3A-1kwcB:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 1kwc 2,3-DIHYDROXYBIPHENY
L DIOXYGENASE
(Pseudomonas
sp.
KKS102) 		4 / 8 GLU B   3
ARG B 192
GLY B 139
ARG B   4
 None
 1.00A 4fgzA-1kwcB:
undetectable
4fgzB-1kwcB:
undetectable		 4fgzA-1kwcB:
18.21
4fgzB-1kwcB:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_B_FK5B203_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 1kwc 2,3-DIHYDROXYBIPHENY
L DIOXYGENASE
(Pseudomonas
sp.
KKS102) 		3 / 3 ALA B  42
GLN B 141
GLY B 191
 None
 0.53A 4odoC-1kwcB:
undetectable		 4odoC-1kwcB:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_1
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 1kwc 2,3-DIHYDROXYBIPHENY
L DIOXYGENASE
(Pseudomonas
sp.
KKS102) 		3 / 3 SER B 247
TYR B 249
ASP B 243
 None
None
BPY  B 401 (-3.9A)
 0.88A 4rp8C-1kwcB:
0.0		 4rp8C-1kwcB:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP4_A_COCA706_1
(DOPAMINE TRANSPORTER)		 1kwc 2,3-DIHYDROXYBIPHENY
L DIOXYGENASE
(Pseudomonas
sp.
KKS102) 		5 / 11 ALA B 131
VAL B 259
GLY B 221
PHE B 248
GLY B 262
 None
 1.12A 4xp4A-1kwcB:
undetectable		 4xp4A-1kwcB:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 1kwc 2,3-DIHYDROXYBIPHENY
L DIOXYGENASE
(Pseudomonas
sp.
KKS102) 		4 / 7 ALA B  42
ARG B  97
GLY B  63
GLU B 114
 None
 1.00A 5bs8A-1kwcB:
0.0
5bs8B-1kwcB:
undetectable
5bs8C-1kwcB:
undetectable		 5bs8A-1kwcB:
19.76
5bs8B-1kwcB:
22.05
5bs8C-1kwcB:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_E_GFNE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 1kwc 2,3-DIHYDROXYBIPHENY
L DIOXYGENASE
(Pseudomonas
sp.
KKS102) 		4 / 7 ALA B  42
ARG B  97
GLY B  63
GLU B 114
 None
 0.99A 5btdA-1kwcB:
0.0
5btdB-1kwcB:
undetectable
5btdC-1kwcB:
undetectable		 5btdA-1kwcB:
19.76
5btdB-1kwcB:
22.05
5btdC-1kwcB:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C6P_A_4YHA601_1
(PROTEIN C)		 1kwc 2,3-DIHYDROXYBIPHENY
L DIOXYGENASE
(Pseudomonas
sp.
KKS102) 		4 / 6 ALA B 145
SER B 247
ASP B 243
PRO B 265
 None
None
BPY  B 401 (-3.9A)
None
 1.14A 5c6pA-1kwcB:
undetectable		 5c6pA-1kwcB:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4N_C_ACTC201_0
(NITROGEN REGULATORY
PROTEIN P-II)		 1kwc 2,3-DIHYDROXYBIPHENY
L DIOXYGENASE
(Pseudomonas
sp.
KKS102) 		4 / 5 VAL B 133
VAL B 220
GLY B 221
PHE B 261
 None
 0.82A 5d4nA-1kwcB:
0.0
5d4nC-1kwcB:
0.0		 5d4nA-1kwcB:
21.10
5d4nC-1kwcB:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_U_BEZU801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1kwc 2,3-DIHYDROXYBIPHENY
L DIOXYGENASE
(Pseudomonas
sp.
KKS102) 		4 / 6 PHE B 166
ALA B 197
HIS B 193
LEU B 168
 None
 1.27A 5dzkg-1kwcB:
undetectable
5dzku-1kwcB:
undetectable		 5dzkg-1kwcB:
20.95
5dzku-1kwcB:
1.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1kwc 2,3-DIHYDROXYBIPHENY
L DIOXYGENASE
(Pseudomonas
sp.
KKS102) 		4 / 7 ILE B 143
GLY B 142
LEU B 198
PHE B 186
 None
None
None
BPY  B 401 (-4.4A)
 0.60A 5hieB-1kwcB:
undetectable		 5hieB-1kwcB:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 1kwc 2,3-DIHYDROXYBIPHENY
L DIOXYGENASE
(Pseudomonas
sp.
KKS102) 		3 / 3 ASP B 243
ASN B 190
GLN B 141
 BPY  B 401 (-3.9A)
None
None
 0.79A 5k7uA-1kwcB:
0.7		 5k7uA-1kwcB:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_1
(NS3 PROTEASE)		 1kwc 2,3-DIHYDROXYBIPHENY
L DIOXYGENASE
(Pseudomonas
sp.
KKS102) 		5 / 9 VAL B  99
GLY B 118
ILE B 143
LEU B   5
ARG B  97
 None
 1.45A 6c2mC-1kwcB:
undetectable		 6c2mC-1kwcB:
15.07