SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1kwg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_A_SAMA105_0
(MET REPRESSOR)		 1kwg BETA-GALACTOSIDASE
(Thermus
thermophilus) 		5 / 10 GLY A 577
ARG A 560
GLU A 586
LEU A 583
PRO A 478
 MPD  A 803 (-3.6A)
ACT  A 805 (-4.0A)
ACT  A 805 ( 4.2A)
ACT  A 805 ( 4.8A)
None
 1.38A 1cmcA-1kwgA:
undetectable
1cmcB-1kwgA:
undetectable		 1cmcA-1kwgA:
9.03
1cmcB-1kwgA:
9.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_A_FFOA1002_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1kwg BETA-GALACTOSIDASE
(Thermus
thermophilus) 		5 / 12 LEU A 579
GLY A 577
LEU A 583
ALA A 433
PHE A 481
 None
MPD  A 803 (-3.6A)
ACT  A 805 ( 4.8A)
MPD  A 803 (-3.6A)
None
 1.05A 1dfoA-1kwgA:
undetectable		 1dfoA-1kwgA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_B_FFOB2002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1kwg BETA-GALACTOSIDASE
(Thermus
thermophilus) 		5 / 12 LEU A 579
GLY A 577
LEU A 583
ALA A 433
PHE A 481
 None
MPD  A 803 (-3.6A)
ACT  A 805 ( 4.8A)
MPD  A 803 (-3.6A)
None
 1.06A 1dfoB-1kwgA:
undetectable		 1dfoB-1kwgA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_C_FFOC3002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1kwg BETA-GALACTOSIDASE
(Thermus
thermophilus) 		5 / 12 LEU A 579
GLY A 577
LEU A 583
ALA A 433
PHE A 481
 None
MPD  A 803 (-3.6A)
ACT  A 805 ( 4.8A)
MPD  A 803 (-3.6A)
None
 1.06A 1dfoC-1kwgA:
undetectable		 1dfoC-1kwgA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_D_FFOD4002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1kwg BETA-GALACTOSIDASE
(Thermus
thermophilus) 		5 / 12 LEU A 579
GLY A 577
LEU A 583
ALA A 433
PHE A 481
 None
MPD  A 803 (-3.6A)
ACT  A 805 ( 4.8A)
MPD  A 803 (-3.6A)
None
 1.06A 1dfoD-1kwgA:
undetectable		 1dfoD-1kwgA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSC_C_DVAC2_0
(ACTINOMYCIN D)		 1kwg BETA-GALACTOSIDASE
(Thermus
thermophilus) 		3 / 3 THR A  73
PRO A  76
THR A  75
 None
 0.96A 1dscC-1kwgA:
undetectable		 1dscC-1kwgA:
2.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSD_C_DVAC2_0
(ACTINOMYCIN D)		 1kwg BETA-GALACTOSIDASE
(Thermus
thermophilus) 		4 / 4 THR A  75
PRO A  72
THR A  73
PRO A  76
 None
 1.32A 1dsdC-1kwgA:
undetectable		 1dsdC-1kwgA:
2.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSD_C_DVAC8_0
(ACTINOMYCIN D)		 1kwg BETA-GALACTOSIDASE
(Thermus
thermophilus) 		4 / 4 THR A  75
PRO A  72
THR A  73
PRO A  76
 None
 1.32A 1dsdC-1kwgA:
undetectable		 1dsdC-1kwgA:
2.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1kwg BETA-GALACTOSIDASE
(Thermus
thermophilus) 		5 / 12 LEU A 579
GLY A 577
LEU A 583
ALA A 433
PHE A 481
 None
MPD  A 803 (-3.6A)
ACT  A 805 ( 4.8A)
MPD  A 803 (-3.6A)
None
 1.00A 1eqbA-1kwgA:
undetectable		 1eqbA-1kwgA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_FFOB2293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1kwg BETA-GALACTOSIDASE
(Thermus
thermophilus) 		5 / 12 LEU A 579
GLY A 577
LEU A 583
ALA A 433
PHE A 481
 None
MPD  A 803 (-3.6A)
ACT  A 805 ( 4.8A)
MPD  A 803 (-3.6A)
None
 0.99A 1eqbB-1kwgA:
undetectable		 1eqbB-1kwgA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1kwg BETA-GALACTOSIDASE
(Thermus
thermophilus) 		5 / 12 LEU A 579
GLY A 577
LEU A 583
ALA A 433
PHE A 481
 None
MPD  A 803 (-3.6A)
ACT  A 805 ( 4.8A)
MPD  A 803 (-3.6A)
None
 1.01A 1eqbC-1kwgA:
undetectable		 1eqbC-1kwgA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_FFOD4293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1kwg BETA-GALACTOSIDASE
(Thermus
thermophilus) 		5 / 12 LEU A 579
GLY A 577
LEU A 583
ALA A 433
PHE A 481
 None
MPD  A 803 (-3.6A)
ACT  A 805 ( 4.8A)
MPD  A 803 (-3.6A)
None
 1.00A 1eqbD-1kwgA:
undetectable		 1eqbD-1kwgA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDS_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 1kwg BETA-GALACTOSIDASE
(Thermus
thermophilus) 		5 / 12 VAL A 192
LEU A 173
PRO A 195
SER A 205
PHE A 159
 None
 1.29A 1fdsA-1kwgA:
4.0		 1fdsA-1kwgA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDW_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 1kwg BETA-GALACTOSIDASE
(Thermus
thermophilus) 		5 / 10 VAL A 192
LEU A 173
PRO A 195
SER A 205
PHE A 159
 None
 1.22A 1fdwA-1kwgA:
1.8		 1fdwA-1kwgA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXV_B_PNNB1001_0
(PENICILLIN ACYLASE)		 1kwg BETA-GALACTOSIDASE
(Thermus
thermophilus) 		4 / 7 SER A 572
PHE A 532
ALA A 576
PHE A 430
 None
 0.96A 1fxvA-1kwgA:
0.0
1fxvB-1kwgA:
0.0		 1fxvA-1kwgA:
13.85
1fxvB-1kwgA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IWI_A_CAMA418_0
(CYTOCHROME P450-CAM)		 1kwg BETA-GALACTOSIDASE
(Thermus
thermophilus) 		4 / 8 THR A 247
LEU A 424
VAL A 427
VAL A 443
 None
MPD  A 802 ( 4.4A)
None
None
 0.92A 1iwiA-1kwgA:
0.0		 1iwiA-1kwgA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_D_SAMD200_0
(METHIONINE REPRESSOR)		 1kwg BETA-GALACTOSIDASE
(Thermus
thermophilus) 		5 / 12 ALA A 454
GLY A 452
LEU A 583
GLU A 586
ALA A 587
 None
None
ACT  A 805 ( 4.8A)
ACT  A 805 ( 4.2A)
None
 1.07A 1mjqC-1kwgA:
undetectable
1mjqD-1kwgA:
undetectable		 1mjqC-1kwgA:
9.03
1mjqD-1kwgA:
9.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_G_SAMG199_0
(METHIONINE REPRESSOR)		 1kwg BETA-GALACTOSIDASE
(Thermus
thermophilus) 		5 / 10 ARG A 560
GLU A 586
ALA A 587
ALA A 454
GLY A 452
 ACT  A 805 (-4.0A)
ACT  A 805 ( 4.2A)
None
None
None
 1.18A 1mjqG-1kwgA:
undetectable
1mjqH-1kwgA:
undetectable		 1mjqG-1kwgA:
9.03
1mjqH-1kwgA:
9.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_J_SAMJ200_0
(METHIONINE REPRESSOR)		 1kwg BETA-GALACTOSIDASE
(Thermus
thermophilus) 		5 / 12 ALA A 454
GLY A 452
LEU A 583
GLU A 586
ALA A 587
 None
None
ACT  A 805 ( 4.8A)
ACT  A 805 ( 4.2A)
None
 1.06A 1mjqI-1kwgA:
undetectable
1mjqJ-1kwgA:
undetectable		 1mjqI-1kwgA:
9.03
1mjqJ-1kwgA:
9.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT5_A_DVAA6_0
(GRAMICIDIN A)		 1kwg BETA-GALACTOSIDASE
(Thermus
thermophilus) 		3 / 3 ALA A 328
VAL A 332
TRP A 335
 None
 0.89A 1nt5A-1kwgA:
undetectable		 1nt5A-1kwgA:
2.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT5_B_DVAB6_0
(GRAMICIDIN A)		 1kwg BETA-GALACTOSIDASE
(Thermus
thermophilus) 		3 / 3 ALA A 328
VAL A 332
TRP A 335
 None
 0.89A 1nt5B-1kwgA:
undetectable		 1nt5B-1kwgA:
2.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OVF_B_DVAB2_0
(ACTINOMYCIN D)		 1kwg BETA-GALACTOSIDASE
(Thermus
thermophilus) 		3 / 3 THR A  73
PRO A  76
THR A  75
 None
 0.88A 1ovfB-1kwgA:
undetectable		 1ovfB-1kwgA:
2.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_H_FUAH709_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1kwg BETA-GALACTOSIDASE
(Thermus
thermophilus) 		5 / 12 LEU A 402
VAL A 443
PHE A 295
VAL A 427
VAL A 303
 None
 1.24A 1q23H-1kwgA:
0.0
1q23I-1kwgA:
0.0		 1q23H-1kwgA:
15.04
1q23I-1kwgA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_B_017B203_1
(HIV-1 PROTEASE)		 1kwg BETA-GALACTOSIDASE
(Thermus
thermophilus) 		5 / 7 TRP A  11
PRO A 356
MET A 362
ARG A 353
GLY A 365
 CL  A 801 (-4.4A)
None
None
None
None
 1.46A 2hs1B-1kwgA:
undetectable		 2hs1B-1kwgA:
9.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_FFOB505_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1kwg BETA-GALACTOSIDASE
(Thermus
thermophilus) 		5 / 12 LEU A 579
GLY A 577
LEU A 583
ALA A 433
GLY A 482
 None
MPD  A 803 (-3.6A)
ACT  A 805 ( 4.8A)
MPD  A 803 (-3.6A)
None
 1.03A 2vmyA-1kwgA:
undetectable		 2vmyA-1kwgA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z97_A_CAMA422_0
(CYTOCHROME P450-CAM)		 1kwg BETA-GALACTOSIDASE
(Thermus
thermophilus) 		4 / 6 THR A 247
LEU A 424
VAL A 427
VAL A 443
 None
MPD  A 802 ( 4.4A)
None
None
 0.89A 2z97A-1kwgA:
0.0		 2z97A-1kwgA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOB_C_RFPC2002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 1kwg BETA-GALACTOSIDASE
(Thermus
thermophilus) 		5 / 12 PHE A 252
ALA A 253
PHE A 246
ARG A 149
ARG A 219
 None
 0.92A 3aobC-1kwgA:
0.0		 3aobC-1kwgA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_A_ERYA195_1
(REPRESSOR PROTEIN
MPHR(A))		 1kwg BETA-GALACTOSIDASE
(Thermus
thermophilus) 		4 / 5 ASN A 319
ARG A 102
HIS A  10
ALA A 355
 None
 1.21A 3frqA-1kwgA:
undetectable		 3frqA-1kwgA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_1
(REPRESSOR PROTEIN
MPHR(A))		 1kwg BETA-GALACTOSIDASE
(Thermus
thermophilus) 		4 / 7 ASN A 319
ARG A 102
HIS A  10
ALA A 355
 None
 1.25A 3frqB-1kwgA:
undetectable		 3frqB-1kwgA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HTH_B_PRLB201_0
(EBRA REPRESSOR)		 1kwg BETA-GALACTOSIDASE
(Thermus
thermophilus) 		5 / 9 VAL A 120
LEU A  69
TRP A  50
LEU A  53
ASP A  54
 None
 1.18A 3hthB-1kwgA:
1.4		 3hthB-1kwgA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1kwg BETA-GALACTOSIDASE
(Thermus
thermophilus) 		5 / 12 TYR A   6
ILE A  33
LEU A  69
ALA A  58
VAL A 133
 CL  A 801 (-4.9A)
None
None
None
None
 1.03A 3rukA-1kwgA:
undetectable		 3rukA-1kwgA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1kwg BETA-GALACTOSIDASE
(Thermus
thermophilus) 		5 / 12 TYR A   6
ILE A  33
LEU A  69
ALA A  61
VAL A 133
 CL  A 801 (-4.9A)
None
None
None
None
 0.93A 3rukA-1kwgA:
undetectable		 3rukA-1kwgA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1kwg BETA-GALACTOSIDASE
(Thermus
thermophilus) 		5 / 12 ILE A  57
LEU A  60
GLY A  34
VAL A  67
VAL A 133
 None
 1.01A 3rukB-1kwgA:
undetectable		 3rukB-1kwgA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S53_B_017B203_1
(PROTEASE)		 1kwg BETA-GALACTOSIDASE
(Thermus
thermophilus) 		4 / 5 TRP A  11
PRO A 356
ARG A 353
GLY A 365
 CL  A 801 (-4.4A)
None
None
None
 1.36A 3s53B-1kwgA:
0.0		 3s53B-1kwgA:
9.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_E_CLME221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1kwg BETA-GALACTOSIDASE
(Thermus
thermophilus) 		5 / 10 PHE A 252
LEU A 461
VAL A 464
PHE A 472
VAL A 458
 None
 1.38A 3u9fE-1kwgA:
0.0		 3u9fE-1kwgA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_H_CLMH221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1kwg BETA-GALACTOSIDASE
(Thermus
thermophilus) 		5 / 12 SER A 487
LEU A 461
VAL A 403
PHE A 472
VAL A 464
 None
 1.47A 3u9fH-1kwgA:
0.0
3u9fI-1kwgA:
0.0		 3u9fH-1kwgA:
15.04
3u9fI-1kwgA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_I_CLMI221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1kwg BETA-GALACTOSIDASE
(Thermus
thermophilus) 		5 / 10 PHE A 252
LEU A 461
VAL A 464
PHE A 472
VAL A 458
 None
 1.37A 3u9fI-1kwgA:
undetectable		 3u9fI-1kwgA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_I_CLMI221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1kwg BETA-GALACTOSIDASE
(Thermus
thermophilus) 		5 / 10 SER A 487
LEU A 461
VAL A 403
PHE A 472
VAL A 464
 None
 1.50A 3u9fI-1kwgA:
undetectable		 3u9fI-1kwgA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_N_CLMN221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1kwg BETA-GALACTOSIDASE
(Thermus
thermophilus) 		5 / 11 PHE A 252
LEU A 461
VAL A 464
PHE A 472
VAL A 458
 None
 1.35A 3u9fN-1kwgA:
0.0
3u9fO-1kwgA:
undetectable		 3u9fN-1kwgA:
15.04
3u9fO-1kwgA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_P_CLMP221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1kwg BETA-GALACTOSIDASE
(Thermus
thermophilus) 		5 / 9 PHE A 252
LEU A 461
VAL A 464
PHE A 472
VAL A 458
 None
 1.31A 3u9fP-1kwgA:
0.0		 3u9fP-1kwgA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_R_CLMR221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1kwg BETA-GALACTOSIDASE
(Thermus
thermophilus) 		5 / 10 PHE A 252
LEU A 461
VAL A 464
PHE A 472
VAL A 458
 None
 1.34A 3u9fR-1kwgA:
0.0		 3u9fR-1kwgA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_B_017B202_1
(PROTEASE)		 1kwg BETA-GALACTOSIDASE
(Thermus
thermophilus) 		5 / 7 TRP A  11
PRO A 356
MET A 362
ARG A 353
GLY A 365
 CL  A 801 (-4.4A)
None
None
None
None
 1.46A 3ucbB-1kwgA:
undetectable		 3ucbB-1kwgA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOD_A_HQEA1173_1
(FMN-BINDING PROTEIN)		 1kwg BETA-GALACTOSIDASE
(Thermus
thermophilus) 		4 / 7 TYR A 428
ASP A 291
HIS A 297
HIS A 289
 MPD  A 802 ( 4.4A)
None
None
None
 1.41A 3zodA-1kwgA:
0.0		 3zodA-1kwgA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7H_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 1kwg BETA-GALACTOSIDASE
(Thermus
thermophilus) 		3 / 3 ARG A 626
THR A 605
TRP A 606
 None
 0.96A 4d7hA-1kwgA:
1.0		 4d7hA-1kwgA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 1kwg BETA-GALACTOSIDASE
(Thermus
thermophilus) 		4 / 6 PHE A 608
ALA A 341
GLY A 604
LEU A 392
 None
 0.87A 4dubA-1kwgA:
0.0		 4dubA-1kwgA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GRK_A_KTRA713_1
(LACTOTRANSFERRIN)		 1kwg BETA-GALACTOSIDASE
(Thermus
thermophilus) 		4 / 5 GLY A 486
VAL A 464
PRO A 462
TYR A 412
 None
 0.97A 4grkA-1kwgA:
0.0		 4grkA-1kwgA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4B_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 1kwg BETA-GALACTOSIDASE
(Thermus
thermophilus) 		4 / 8 THR A 247
LEU A 424
VAL A 427
VAL A 443
 None
MPD  A 802 ( 4.4A)
None
None
 0.92A 4l4bA-1kwgA:
0.0		 4l4bA-1kwgA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA303_1
(CHITOSANASE)		 1kwg BETA-GALACTOSIDASE
(Thermus
thermophilus) 		4 / 6 GLU A 360
TYR A   7
HIS A 145
TYR A 266
 None
 1.33A 4qwpA-1kwgA:
0.0		 4qwpA-1kwgA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RDX_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 1kwg BETA-GALACTOSIDASE
(Thermus
thermophilus) 		4 / 7 THR A 287
ARG A 599
GLY A 597
GLY A 613
 None
 0.88A 4rdxA-1kwgA:
undetectable		 4rdxA-1kwgA:
25.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_A_SAMA2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 1kwg BETA-GALACTOSIDASE
(Thermus
thermophilus) 		5 / 12 GLY A 482
TRP A 570
SER A 485
LEU A 461
ALA A 408
 None
 0.99A 4uciA-1kwgA:
undetectable		 4uciA-1kwgA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_SAMB2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 1kwg BETA-GALACTOSIDASE
(Thermus
thermophilus) 		5 / 12 GLY A 482
TRP A 570
SER A 485
LEU A 461
ALA A 408
 None
 1.00A 4uciB-1kwgA:
undetectable		 4uciB-1kwgA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_B_SAMB2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 1kwg BETA-GALACTOSIDASE
(Thermus
thermophilus) 		5 / 12 GLY A 482
TRP A 570
SER A 485
LEU A 461
ALA A 408
 None
 0.99A 4uckB-1kwgA:
undetectable		 4uckB-1kwgA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UG5_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 1kwg BETA-GALACTOSIDASE
(Thermus
thermophilus) 		3 / 3 ARG A 626
THR A 605
TRP A 606
 None
 1.05A 4ug5A-1kwgA:
0.0		 4ug5A-1kwgA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UGL_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE)		 1kwg BETA-GALACTOSIDASE
(Thermus
thermophilus) 		3 / 3 ARG A 626
THR A 605
TRP A 606
 None
 0.98A 4uglA-1kwgA:
0.9		 4uglA-1kwgA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4USW_A_ACTA1470_0
(ADENYLATE CYCLASE
TYPE 10)		 1kwg BETA-GALACTOSIDASE
(Thermus
thermophilus) 		4 / 6 LEU A 258
LEU A 229
VAL A 226
PHE A 237
 None
 1.25A 4uswA-1kwgA:
0.0		 4uswA-1kwgA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_B_BQ1B1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 1kwg BETA-GALACTOSIDASE
(Thermus
thermophilus) 		4 / 8 ALA A 293
ALA A 294
ALA A 609
PHE A 608
 None
 0.63A 4v1fA-1kwgA:
undetectable
4v1fB-1kwgA:
undetectable		 4v1fA-1kwgA:
10.14
4v1fB-1kwgA:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XMF_A_HSMA202_1
(NITROPHORIN-7)		 1kwg BETA-GALACTOSIDASE
(Thermus
thermophilus) 		3 / 3 ASP A 638
LEU A 629
GLY A 630
 None
 0.53A 4xmfA-1kwgA:
0.0		 4xmfA-1kwgA:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6C_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 1kwg BETA-GALACTOSIDASE
(Thermus
thermophilus) 		3 / 3 ARG A 626
THR A 605
TRP A 606
 None
 0.97A 5g6cA-1kwgA:
0.0		 5g6cA-1kwgA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_C_SALC201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 1kwg BETA-GALACTOSIDASE
(Thermus
thermophilus) 		4 / 7 ARG A 333
PRO A 329
GLY A 330
TYR A 637
 None
 1.00A 5x80C-1kwgA:
undetectable
5x80D-1kwgA:
undetectable		 5x80C-1kwgA:
13.78
5x80D-1kwgA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA609_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 1kwg BETA-GALACTOSIDASE
(Thermus
thermophilus) 		3 / 3 HIS A 297
HIS A 342
ARG A 435
 None
 0.94A 6b58A-1kwgA:
undetectable		 6b58A-1kwgA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_D_ACTD404_0
(L-LYSINE
3-HYDROXYLASE)		 1kwg BETA-GALACTOSIDASE
(Thermus
thermophilus) 		4 / 6 GLN A 361
GLU A 360
HIS A  10
ALA A 355
 None
 1.20A 6f6jC-1kwgA:
0.0
6f6jD-1kwgA:
0.0		 6f6jC-1kwgA:
22.21
6f6jD-1kwgA:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_A_LLLA301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 1kwg BETA-GALACTOSIDASE
(Thermus
thermophilus) 		4 / 6 ASP A 291
TYR A 284
GLU A 280
GLU A 574
 None
None
None
MPD  A 803 ( 4.4A)
 1.36A 6mn5A-1kwgA:
0.1		 6mn5A-1kwgA:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_C_LLLC301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 1kwg BETA-GALACTOSIDASE
(Thermus
thermophilus) 		4 / 6 ASP A 291
TYR A 284
GLU A 280
GLU A 574
 None
None
None
MPD  A 803 ( 4.4A)
 1.34A 6mn5C-1kwgA:
0.2		 6mn5C-1kwgA:
7.63