SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1kwm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTX_A_CVIA200_0
(HYPOTHETICAL
TRANSCRIPTIONAL
REGULATOR IN QACA
5'REGION)		 1kwm PROCARBOXYPEPTIDASE
B
(Homo
sapiens) 		5 / 12 ILE A 189
ILE A 263
TYR A 192
ILE A  47
ALA A 178
 None
 1.09A 1jtxA-1kwmA:
undetectable		 1jtxA-1kwmA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_1
(MODIFICATION
METHYLASE RSRI)		 1kwm PROCARBOXYPEPTIDASE
B
(Homo
sapiens) 		3 / 3 ASP A 255
HIS A 196
ASP A  65
 None
ZN  A 400 (-3.3A)
None
 0.64A 1nw5A-1kwmA:
2.1		 1nw5A-1kwmA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_A_RBFA296_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 1kwm PROCARBOXYPEPTIDASE
B
(Homo
sapiens) 		5 / 11 THR A  41
VAL A 110
ASN A 112
GLU A 175
ILE A 117
 None
 1.38A 1t6zA-1kwmA:
1.3		 1t6zA-1kwmA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLM_A_MILA128_1
(TRANSTHYRETIN)		 1kwm PROCARBOXYPEPTIDASE
B
(Homo
sapiens) 		3 / 3 LEU A 108
LEU A  49
SER A  36
 None
 0.51A 1tlmA-1kwmA:
0.0		 1tlmA-1kwmA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT6_A_DESA129_1
(TRANSTHYRETIN)		 1kwm PROCARBOXYPEPTIDASE
B
(Homo
sapiens) 		4 / 4 LYS A 190
LEU A 308
LEU A 305
SER A 302
 None
 1.47A 1tt6A-1kwmA:
0.0		 1tt6A-1kwmA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_A_NCAA1252_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 1kwm PROCARBOXYPEPTIDASE
B
(Homo
sapiens) 		4 / 7 SER A 199
SER A 197
PHE A 279
GLU A 270
 None
 1.27A 2c8aA-1kwmA:
undetectable		 2c8aA-1kwmA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_B_NCAB1246_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 1kwm PROCARBOXYPEPTIDASE
B
(Homo
sapiens) 		5 / 7 GLY A 278
SER A 199
SER A 197
PHE A 279
GLU A 270
 None
 1.32A 2c8aB-1kwmA:
undetectable		 2c8aB-1kwmA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_C_NCAC1252_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 1kwm PROCARBOXYPEPTIDASE
B
(Homo
sapiens) 		4 / 6 SER A 199
SER A 197
PHE A 279
GLU A 270
 None
 1.33A 2c8aC-1kwmA:
undetectable		 2c8aC-1kwmA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_B_SALB503_1
(SALICYLATE
SYNTHETASE, IRP9)		 1kwm PROCARBOXYPEPTIDASE
B
(Homo
sapiens) 		5 / 11 GLU A 163
GLY A 140
THR A 129
GLY A 167
GLU A 173
 None
 1.41A 2fn1B-1kwmA:
undetectable		 2fn1B-1kwmA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXD_A_DR7A102_1
(POL PROTEIN)		 1kwm PROCARBOXYPEPTIDASE
B
(Homo
sapiens) 		5 / 11 ILE A  62
GLY A 262
ASP A 260
GLY A 213
PHE A 267
 None
 1.14A 2fxdA-1kwmA:
undetectable		 2fxdA-1kwmA:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GJ5_A_VD3A163_1
(BETA-LACTOGLOBULIN)		 1kwm PROCARBOXYPEPTIDASE
B
(Homo
sapiens) 		5 / 12 VAL A  96
LEU A  99
GLU A 306
ALA A 191
PHE A 294
 None
 1.22A 2gj5A-1kwmA:
undetectable		 2gj5A-1kwmA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_A_SC2A1290_1
(FICOLIN-2)		 1kwm PROCARBOXYPEPTIDASE
B
(Homo
sapiens) 		4 / 5 SER A 197
LEU A 280
GLY A 278
ARG A 124
 None
 0.92A 2j2pA-1kwmA:
0.0
2j2pB-1kwmA:
0.0		 2j2pA-1kwmA:
19.16
2j2pB-1kwmA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_C_SC2C1289_1
(FICOLIN-2)		 1kwm PROCARBOXYPEPTIDASE
B
(Homo
sapiens) 		4 / 6 ARG A 124
SER A 197
LEU A 280
GLY A 278
 None
 0.94A 2j2pA-1kwmA:
0.0
2j2pC-1kwmA:
0.0		 2j2pA-1kwmA:
19.16
2j2pC-1kwmA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1289_1
(FICOLIN-2)		 1kwm PROCARBOXYPEPTIDASE
B
(Homo
sapiens) 		4 / 6 ARG A 124
SER A 197
LEU A 280
GLY A 278
 None
 0.92A 2j2pD-1kwmA:
undetectable
2j2pF-1kwmA:
0.0		 2j2pD-1kwmA:
19.16
2j2pF-1kwmA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_A_BEZA143_0
(PUTATIVE REDOX
PROTEIN)		 1kwm PROCARBOXYPEPTIDASE
B
(Homo
sapiens) 		4 / 7 ALA A 223
THR A 226
ALA A 225
TYR A 303
 None
 0.99A 2ql8A-1kwmA:
0.0
2ql8B-1kwmA:
1.5		 2ql8A-1kwmA:
16.29
2ql8B-1kwmA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1162_1
(ALLERGEN ARG R 1)		 1kwm PROCARBOXYPEPTIDASE
B
(Homo
sapiens) 		4 / 4 GLU A 270
ASP A 142
HIS A  69
GLU A  72
 None
None
ZN  A 400 (-3.9A)
ZN  A 400 (-2.1A)
 1.18A 2x45A-1kwmA:
0.0		 2x45A-1kwmA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1162_1
(ALLERGEN ARG R 1)		 1kwm PROCARBOXYPEPTIDASE
B
(Homo
sapiens) 		3 / 3 GLU A 270
HIS A  69
GLU A  72
 None
ZN  A 400 (-3.9A)
ZN  A 400 (-2.1A)
 0.85A 2x45B-1kwmA:
0.0		 2x45B-1kwmA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1162_1
(ALLERGEN ARG R 1)		 1kwm PROCARBOXYPEPTIDASE
B
(Homo
sapiens) 		3 / 3 GLU A 270
HIS A  69
GLU A  72
 None
ZN  A 400 (-3.9A)
ZN  A 400 (-2.1A)
 0.87A 2x45C-1kwmA:
0.0		 2x45C-1kwmA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_A_Y00A601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 1kwm PROCARBOXYPEPTIDASE
B
(Homo
sapiens) 		5 / 12 TRP A  38
ASP A  53
VAL A  52
SER A  50
TYR A 198
 None
 1.49A 2y00A-1kwmA:
undetectable		 2y00A-1kwmA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_B_Y00B601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 1kwm PROCARBOXYPEPTIDASE
B
(Homo
sapiens) 		5 / 12 TRP A  38
ASP A  53
VAL A  52
SER A  50
TYR A 198
 None
 1.49A 2y00B-1kwmA:
undetectable		 2y00B-1kwmA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D4S_A_TIMA401_2
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		 1kwm PROCARBOXYPEPTIDASE
B
(Homo
sapiens) 		3 / 3 THR A  32
SER A  31
PHE A  54
 None
 0.87A 3d4sA-1kwmA:
undetectable		 3d4sA-1kwmA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TAJ_A_NBOA700_1
(LACTOTRANSFERRIN)		 1kwm PROCARBOXYPEPTIDASE
B
(Homo
sapiens) 		4 / 7 THR A 129
GLY A 115
ASN A 112
GLY A  44
 None
 0.82A 3tajA-1kwmA:
undetectable		 3tajA-1kwmA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FJP_A_NPSA711_1
(LACTOTRANSFERRIN)		 1kwm PROCARBOXYPEPTIDASE
B
(Homo
sapiens) 		4 / 6 THR A 129
GLY A 115
ASN A 112
GLY A  44
 None
 0.78A 4fjpA-1kwmA:
undetectable		 4fjpA-1kwmA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOR_A_FLPA711_1
(LACTOTRANSFERRIN)		 1kwm PROCARBOXYPEPTIDASE
B
(Homo
sapiens) 		4 / 7 THR A 129
GLY A 115
ASN A 112
GLY A  44
 None
 0.83A 4forA-1kwmA:
undetectable		 4forA-1kwmA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KN2_C_LYAC304_2
(FOLATE RECEPTOR BETA)		 1kwm PROCARBOXYPEPTIDASE
B
(Homo
sapiens) 		3 / 3 TYR A 208
GLN A 261
TRP A 151
 None
 0.93A 4kn2C-1kwmA:
0.0		 4kn2C-1kwmA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJG_A_SAMA302_0
(7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE)		 1kwm PROCARBOXYPEPTIDASE
B
(Homo
sapiens) 		5 / 12 GLU A  72
ASP A 142
THR A 268
GLU A 270
LYS A  39
 ZN  A 400 (-2.1A)
None
None
None
None
 1.47A 4njgA-1kwmA:
0.4		 4njgA-1kwmA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1kwm PROCARBOXYPEPTIDASE
B
(Homo
sapiens) 		4 / 6 GLU A 292
THR A 293
THR A 268
HIS A 196
 None
None
None
ZN  A 400 (-3.3A)
 1.37A 4pfjB-1kwmA:
2.2		 4pfjB-1kwmA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_2
(CYTOCHROME P450 2D6)		 1kwm PROCARBOXYPEPTIDASE
B
(Homo
sapiens) 		3 / 3 GLU A 175
ILE A 139
ALA A  70
 None
 0.63A 4wnwB-1kwmA:
0.0		 4wnwB-1kwmA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDQ_A_BEZA306_0
(GLYCOSIDE HYDROLASE
FAMILY PROTEIN)		 1kwm PROCARBOXYPEPTIDASE
B
(Homo
sapiens) 		3 / 3 ARG A  55
ASP A  36
TRP A  38
 None
 0.72A 4xdqA-1kwmA:
undetectable		 4xdqA-1kwmA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 1kwm PROCARBOXYPEPTIDASE
B
(Homo
sapiens) 		4 / 5 THR A 164
GLU A  72
HIS A 196
ASP A  41
 None
ZN  A 400 (-2.1A)
ZN  A 400 (-3.3A)
None
 1.16A 5c0oH-1kwmA:
undetectable		 5c0oH-1kwmA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_0
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 1kwm PROCARBOXYPEPTIDASE
B
(Homo
sapiens) 		5 / 12 GLU A  72
PRO A 143
THR A  44
SER A 157
GLY A 155
 ZN  A 400 (-2.1A)
None
None
None
None
 1.47A 5xioA-1kwmA:
2.3		 5xioA-1kwmA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1kwm PROCARBOXYPEPTIDASE
B
(Homo
sapiens) 		3 / 3 SER A 131
HIS A 133
TYR A 165
 None
 1.04A 5y2tA-1kwmA:
0.0		 5y2tA-1kwmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZWR_A_9KLA402_0
(EST-Y29)		 1kwm PROCARBOXYPEPTIDASE
B
(Homo
sapiens) 		5 / 12 PHE A  78
ILE A 195
LEU A 271
ALA A 296
LEU A 230
 None
 1.04A 5zwrA-1kwmA:
0.0		 5zwrA-1kwmA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZWR_B_9KLB402_0
(EST-Y29)		 1kwm PROCARBOXYPEPTIDASE
B
(Homo
sapiens) 		5 / 12 PHE A  78
ILE A 195
LEU A 271
ALA A 296
LEU A 230
 None
 1.01A 5zwrB-1kwmA:
0.0		 5zwrB-1kwmA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 1kwm PROCARBOXYPEPTIDASE
B
(Homo
sapiens) 		4 / 7 VAL A  37
ILE A 113
GLY A   6
ALA A  20
 None
 0.86A 6hd6B-1kwmA:
undetectable		 6hd6B-1kwmA:
10.25