SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1kyh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_0
(FTSJ)		 1kyh HYPOTHETICAL 29.9
KDA PROTEIN IN
SIGY-CYDD INTERGENIC
REGION
(Bacillus
subtilis) 		5 / 12 ALA A  87
GLY A 102
GLY A  61
GLY A  83
LEU A 132
 None
 0.83A 1eizA-1kyhA:
4.2		 1eizA-1kyhA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_0
(FTSJ)		 1kyh HYPOTHETICAL 29.9
KDA PROTEIN IN
SIGY-CYDD INTERGENIC
REGION
(Bacillus
subtilis) 		5 / 12 ALA A  87
GLY A 102
GLY A  61
GLY A  83
LEU A 132
 None
 0.85A 1ej0A-1kyhA:
4.1		 1ej0A-1kyhA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 1kyh HYPOTHETICAL 29.9
KDA PROTEIN IN
SIGY-CYDD INTERGENIC
REGION
(Bacillus
subtilis) 		5 / 11 GLY A  41
PRO A  40
GLY A  47
LEU A 223
ILE A 222
 None
 1.07A 1jzsA-1kyhA:
undetectable		 1jzsA-1kyhA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_B_DESB459_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 1kyh HYPOTHETICAL 29.9
KDA PROTEIN IN
SIGY-CYDD INTERGENIC
REGION
(Bacillus
subtilis) 		5 / 12 ALA A 176
VAL A 144
TYR A 137
LEU A 132
PHE A 153
 None
 1.18A 1s9pB-1kyhA:
undetectable		 1s9pB-1kyhA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SH9_B_RITB301_1
(POL POLYPROTEIN)		 1kyh HYPOTHETICAL 29.9
KDA PROTEIN IN
SIGY-CYDD INTERGENIC
REGION
(Bacillus
subtilis) 		5 / 8 ALA A  87
ILE A 101
ILE A  99
ILE A  60
PRO A 103
 None
 1.40A 1sh9A-1kyhA:
undetectable		 1sh9A-1kyhA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_B_IBPB2002_1
(SERUM ALBUMIN)		 1kyh HYPOTHETICAL 29.9
KDA PROTEIN IN
SIGY-CYDD INTERGENIC
REGION
(Bacillus
subtilis) 		5 / 10 ALA A  46
ALA A  50
LEU A  55
LEU A  58
ALA A  30
 None
 1.01A 2bxgB-1kyhA:
undetectable		 2bxgB-1kyhA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRH_A_NIOA200_1
(PROTEIN HP0721)		 1kyh HYPOTHETICAL 29.9
KDA PROTEIN IN
SIGY-CYDD INTERGENIC
REGION
(Bacillus
subtilis) 		4 / 7 GLY A  61
ILE A  70
MET A  51
LEU A  32
 None
 0.90A 2xrhA-1kyhA:
undetectable		 2xrhA-1kyhA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRH_A_NIOA200_1
(PROTEIN HP0721)		 1kyh HYPOTHETICAL 29.9
KDA PROTEIN IN
SIGY-CYDD INTERGENIC
REGION
(Bacillus
subtilis) 		4 / 7 GLY A 130
ILE A 101
GLN A 112
LEU A 132
 None
 0.68A 2xrhA-1kyhA:
undetectable		 2xrhA-1kyhA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_C_VD3C2001_1
(VITAMIN D
HYDROXYLASE)		 1kyh HYPOTHETICAL 29.9
KDA PROTEIN IN
SIGY-CYDD INTERGENIC
REGION
(Bacillus
subtilis) 		5 / 11 THR A 157
MET A 156
LEU A 185
LEU A 132
THR A 219
 None
 1.28A 3a50C-1kyhA:
undetectable		 3a50C-1kyhA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX9_B_SALB1340_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 1kyh HYPOTHETICAL 29.9
KDA PROTEIN IN
SIGY-CYDD INTERGENIC
REGION
(Bacillus
subtilis) 		4 / 8 LEU A 268
SER A 265
THR A 217
ALA A 239
 None
 0.98A 3ax9B-1kyhA:
undetectable		 3ax9B-1kyhA:
12.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_B_URFB400_1
(URIDINE
PHOSPHORYLASE 1)		 1kyh HYPOTHETICAL 29.9
KDA PROTEIN IN
SIGY-CYDD INTERGENIC
REGION
(Bacillus
subtilis) 		4 / 8 THR A 217
GLY A  47
LEU A  45
LEU A  44
 None
 0.87A 3nbqB-1kyhA:
0.0		 3nbqB-1kyhA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QOW_A_SAMA417_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE)		 1kyh HYPOTHETICAL 29.9
KDA PROTEIN IN
SIGY-CYDD INTERGENIC
REGION
(Bacillus
subtilis) 		5 / 12 GLY A 244
GLY A 187
VAL A 184
ALA A 210
ASN A 202
 None
 1.31A 3qowA-1kyhA:
4.0		 3qowA-1kyhA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SO9_A_017A100_1
(HIV-1 PROTEASE)		 1kyh HYPOTHETICAL 29.9
KDA PROTEIN IN
SIGY-CYDD INTERGENIC
REGION
(Bacillus
subtilis) 		4 / 8 GLY A  35
ALA A  34
GLY A  47
THR A 219
 None
 0.68A 3so9A-1kyhA:
undetectable		 3so9A-1kyhA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1kyh HYPOTHETICAL 29.9
KDA PROTEIN IN
SIGY-CYDD INTERGENIC
REGION
(Bacillus
subtilis) 		4 / 8 ILE A 183
LEU A 185
VAL A 159
GLY A 158
 None
 0.85A 3w1wA-1kyhA:
undetectable		 3w1wA-1kyhA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_C_ACTC1113_0
(BLR5658 PROTEIN)		 1kyh HYPOTHETICAL 29.9
KDA PROTEIN IN
SIGY-CYDD INTERGENIC
REGION
(Bacillus
subtilis) 		4 / 4 ASN A 206
ALA A 247
GLY A 205
THR A 204
 None
 1.34A 4bboC-1kyhA:
0.0		 4bboC-1kyhA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 1kyh HYPOTHETICAL 29.9
KDA PROTEIN IN
SIGY-CYDD INTERGENIC
REGION
(Bacillus
subtilis) 		4 / 6 ALA A 114
GLY A 102
PRO A 103
LEU A  33
 None
 1.06A 4dubA-1kyhA:
0.0		 4dubA-1kyhA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKL_A_SUZA201_1
(TRANSTHYRETIN)		 1kyh HYPOTHETICAL 29.9
KDA PROTEIN IN
SIGY-CYDD INTERGENIC
REGION
(Bacillus
subtilis) 		4 / 7 LEU A  74
ALA A  50
LEU A  48
SER A 265
 None
 1.12A 4iklA-1kyhA:
undetectable
4iklB-1kyhA:
undetectable		 4iklA-1kyhA:
16.55
4iklB-1kyhA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_2
(THYROID HORMONE
RECEPTOR ALPHA)		 1kyh HYPOTHETICAL 29.9
KDA PROTEIN IN
SIGY-CYDD INTERGENIC
REGION
(Bacillus
subtilis) 		3 / 3 ILE A  70
MET A  51
ARG A  52
 None
 0.86A 4lnwA-1kyhA:
0.0		 4lnwA-1kyhA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_2
(THYROID HORMONE
RECEPTOR ALPHA)		 1kyh HYPOTHETICAL 29.9
KDA PROTEIN IN
SIGY-CYDD INTERGENIC
REGION
(Bacillus
subtilis) 		3 / 3 ILE A  70
MET A  51
ARG A  52
 None
 0.87A 4lnxA-1kyhA:
0.0		 4lnxA-1kyhA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_2
(TUBULIN BETA-2B
CHAIN)		 1kyh HYPOTHETICAL 29.9
KDA PROTEIN IN
SIGY-CYDD INTERGENIC
REGION
(Bacillus
subtilis) 		5 / 12 CYH A 227
LEU A  55
ALA A 100
ALA A  30
ILE A 126
 None
 0.86A 4o2bD-1kyhA:
3.0		 4o2bD-1kyhA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_D_LOCD502_1
(TUBULIN BETA CHAIN)		 1kyh HYPOTHETICAL 29.9
KDA PROTEIN IN
SIGY-CYDD INTERGENIC
REGION
(Bacillus
subtilis) 		5 / 12 CYH A 227
LEU A  55
ALA A 100
ALA A  30
ILE A 126
 None
 1.15A 4x1iD-1kyhA:
2.5		 4x1iD-1kyhA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_B_LOCB502_1
(TUBULIN BETA CHAIN)		 1kyh HYPOTHETICAL 29.9
KDA PROTEIN IN
SIGY-CYDD INTERGENIC
REGION
(Bacillus
subtilis) 		5 / 12 CYH A 227
LEU A  55
ALA A 100
ALA A  30
ILE A 126
 None
 0.94A 4x20B-1kyhA:
undetectable		 4x20B-1kyhA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA409_0
(FAD:PROTEIN FMN
TRANSFERASE)		 1kyh HYPOTHETICAL 29.9
KDA PROTEIN IN
SIGY-CYDD INTERGENIC
REGION
(Bacillus
subtilis) 		4 / 5 ILE A 192
VAL A 240
ILE A 222
VAL A 184
 None
 0.70A 4xdtA-1kyhA:
undetectable		 4xdtA-1kyhA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XO7_A_ASDA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 1kyh HYPOTHETICAL 29.9
KDA PROTEIN IN
SIGY-CYDD INTERGENIC
REGION
(Bacillus
subtilis) 		4 / 7 VAL A 144
ILE A 145
LEU A  32
LEU A 223
 None
 1.02A 4xo7A-1kyhA:
undetectable		 4xo7A-1kyhA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_C_STRC603_1
(CYTOCHROME P450
21-HYDROXYLASE)		 1kyh HYPOTHETICAL 29.9
KDA PROTEIN IN
SIGY-CYDD INTERGENIC
REGION
(Bacillus
subtilis) 		5 / 12 VAL A 144
LEU A 146
VAL A 118
ILE A 101
GLY A 102
 None
 1.00A 4y8wC-1kyhA:
0.0		 4y8wC-1kyhA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1kyh HYPOTHETICAL 29.9
KDA PROTEIN IN
SIGY-CYDD INTERGENIC
REGION
(Bacillus
subtilis) 		4 / 5 THR A 204
THR A 217
HIS A 262
LEU A 259
 None
 1.07A 5axaA-1kyhA:
4.0		 5axaA-1kyhA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_C_ADNC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1kyh HYPOTHETICAL 29.9
KDA PROTEIN IN
SIGY-CYDD INTERGENIC
REGION
(Bacillus
subtilis) 		4 / 5 THR A 204
THR A 217
HIS A 262
LEU A 259
 None
 1.09A 5axaC-1kyhA:
5.6		 5axaC-1kyhA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_A_SAMA301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 1kyh HYPOTHETICAL 29.9
KDA PROTEIN IN
SIGY-CYDD INTERGENIC
REGION
(Bacillus
subtilis) 		5 / 12 GLY A 215
GLY A 213
ASP A 216
PRO A 103
LEU A 209
 None
 1.19A 5bw4A-1kyhA:
4.1		 5bw4A-1kyhA:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_E_SAME301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 1kyh HYPOTHETICAL 29.9
KDA PROTEIN IN
SIGY-CYDD INTERGENIC
REGION
(Bacillus
subtilis) 		5 / 12 ALA A  42
PRO A  40
GLY A 104
ALA A 131
LEU A  33
 None
 1.12A 5c0oE-1kyhA:
5.1		 5c0oE-1kyhA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5INZ_D_DVAD2_0
(THETA DEFENSIN-2,
D-PEPTIDE
THETA DEFENSIN-2,
L-PEPTIDE)		 1kyh HYPOTHETICAL 29.9
KDA PROTEIN IN
SIGY-CYDD INTERGENIC
REGION
(Bacillus
subtilis) 		4 / 4 GLY A  54
CYH A 227
ARG A  18
GLY A  56
 None
 1.44A 5inzA-1kyhA:
undetectable
5inzC-1kyhA:
undetectable
5inzD-1kyhA:
undetectable		 5inzA-1kyhA:
7.69
5inzC-1kyhA:
7.69
5inzD-1kyhA:
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_B_SAMB501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1kyh HYPOTHETICAL 29.9
KDA PROTEIN IN
SIGY-CYDD INTERGENIC
REGION
(Bacillus
subtilis) 		5 / 9 LEU A  32
ILE A  60
GLY A  61
GLY A  83
ALA A  43
 None
 0.99A 5o96A-1kyhA:
undetectable
5o96B-1kyhA:
2.9		 5o96A-1kyhA:
23.37
5o96B-1kyhA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_D_SAMD501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1kyh HYPOTHETICAL 29.9
KDA PROTEIN IN
SIGY-CYDD INTERGENIC
REGION
(Bacillus
subtilis) 		5 / 10 LEU A  32
ILE A  60
GLY A  61
GLY A  83
ALA A  43
 None
 1.06A 5o96C-1kyhA:
3.5
5o96D-1kyhA:
3.3		 5o96C-1kyhA:
23.37
5o96D-1kyhA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OH1_C_9UQC202_0
(CEREBLON ISOFORM 4)		 1kyh HYPOTHETICAL 29.9
KDA PROTEIN IN
SIGY-CYDD INTERGENIC
REGION
(Bacillus
subtilis) 		4 / 8 ASN A 202
PRO A 203
PHE A   5
TRP A 200
 None
 1.41A 5oh1C-1kyhA:
undetectable		 5oh1C-1kyhA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UTU_H_ADNH503_2
(ADENOSYLHOMOCYSTEINA
SE)		 1kyh HYPOTHETICAL 29.9
KDA PROTEIN IN
SIGY-CYDD INTERGENIC
REGION
(Bacillus
subtilis) 		4 / 5 THR A 204
THR A 217
HIS A 262
LEU A 259
 None
 0.97A 5utuH-1kyhA:
3.7		 5utuH-1kyhA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_B_LOCB504_2
(TUBULIN BETA CHAIN)		 1kyh HYPOTHETICAL 29.9
KDA PROTEIN IN
SIGY-CYDD INTERGENIC
REGION
(Bacillus
subtilis) 		5 / 12 CYH A 227
LEU A  55
ALA A 100
ALA A  30
ILE A 126
 None
 0.82A 5xiwB-1kyhA:
3.0		 5xiwB-1kyhA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_B_NIOB401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 1kyh HYPOTHETICAL 29.9
KDA PROTEIN IN
SIGY-CYDD INTERGENIC
REGION
(Bacillus
subtilis) 		4 / 7 VAL A 184
VAL A 182
ILE A 126
ASP A 128
 None
 0.79A 5yf9B-1kyhA:
undetectable		 5yf9B-1kyhA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CI6_A_NBOA607_1
(SERUM ALBUMIN)		 1kyh HYPOTHETICAL 29.9
KDA PROTEIN IN
SIGY-CYDD INTERGENIC
REGION
(Bacillus
subtilis) 		4 / 7 ASN A 238
ALA A 235
GLU A 230
LEU A  15
 None
 1.07A 6ci6A-1kyhA:
1.6		 6ci6A-1kyhA:
15.69