SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1kyi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBS_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE II)		 1kyi ATP-DEPENDENT HSL
PROTEASE ATP-BINDING
SUBUNIT HSLU
(Haemophilus
influenzae) 		5 / 12 PHE A  78
ILE A  66
ALA A  67
ALA A  71
VAL A  27
 None
 0.98A 1cbsA-1kyiA:
undetectable		 1cbsA-1kyiA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4003_1
(SERUM ALBUMIN)		 1kyi ATP-DEPENDENT HSL
PROTEASE ATP-BINDING
SUBUNIT HSLU
(Haemophilus
influenzae) 		5 / 9 ILE A  66
LEU A 336
GLY A  19
ALA A  23
LEU A 333
 None
ATP  A 450 (-4.8A)
None
None
None
 1.12A 1e7bA-1kyiA:
undetectable		 1e7bA-1kyiA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI518_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 1kyi ATP-DEPENDENT HSL
PROTEASE ATP-BINDING
SUBUNIT HSLU
(Haemophilus
influenzae) 		4 / 7 ILE A  17
GLY A  19
PRO A 348
ARG A 343
 ATP  A 450 (-4.2A)
None
None
None
 0.97A 1oniG-1kyiA:
0.1
1oniI-1kyiA:
0.2		 1oniG-1kyiA:
15.09
1oniI-1kyiA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SH9_B_RITB301_1
(POL POLYPROTEIN)		 1kyi ATP-DEPENDENT HSL
PROTEASE ATP-BINDING
SUBUNIT HSLU
(Haemophilus
influenzae) 		5 / 8 ASP A 428
ALA A 429
ASP A 405
ILE A 421
ILE A 407
 None
 1.35A 1sh9A-1kyiA:
undetectable		 1sh9A-1kyiA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FR3_A_REAA300_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
2)		 1kyi ATP-DEPENDENT HSL
PROTEASE ATP-BINDING
SUBUNIT HSLU
(Haemophilus
influenzae) 		5 / 12 PHE A  78
ILE A  66
ALA A  67
ALA A  71
VAL A  27
 None
 0.92A 2fr3A-1kyiA:
undetectable		 2fr3A-1kyiA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_K_SAMK302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 1kyi ATP-DEPENDENT HSL
PROTEASE ATP-BINDING
SUBUNIT HSLU
(Haemophilus
influenzae) 		5 / 12 VAL A  61
LEU A 333
ILE A 256
LEU A  54
LEU A 327
 ATP  A 450 (-4.0A)
None
None
None
None
 1.50A 3cjtK-1kyiA:
0.2		 3cjtK-1kyiA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_C_TOPC200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 1kyi ATP-DEPENDENT HSL
PROTEASE ATP-BINDING
SUBUNIT HSLU
(Haemophilus
influenzae) 		5 / 11 ALA A  67
ASN A  52
ILE A 303
LEU A 103
THR A  64
 None
None
None
None
ATP  A 450 (-3.4A)
 1.31A 3fl9C-1kyiA:
undetectable		 3fl9C-1kyiA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB314_1
(UNCHARACTERIZED
PROTEIN)		 1kyi ATP-DEPENDENT HSL
PROTEASE ATP-BINDING
SUBUNIT HSLU
(Haemophilus
influenzae) 		3 / 3 THR A 353
LYS A  24
GLU A 354
 None
 0.83A 3ijdB-1kyiA:
2.1		 3ijdB-1kyiA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_I_TFPI202_1
(PROTEIN S100-A4)		 1kyi ATP-DEPENDENT HSL
PROTEASE ATP-BINDING
SUBUNIT HSLU
(Haemophilus
influenzae) 		5 / 12 LEU A  73
ILE A   9
GLU A  12
LEU A  13
ASP A  14
 None
 1.21A 3ko0G-1kyiA:
0.0
3ko0H-1kyiA:
undetectable
3ko0I-1kyiA:
0.0
3ko0J-1kyiA:
0.0		 3ko0G-1kyiA:
12.19
3ko0H-1kyiA:
12.19
3ko0I-1kyiA:
12.19
3ko0J-1kyiA:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM202_1
(PROTEIN S100-A4)		 1kyi ATP-DEPENDENT HSL
PROTEASE ATP-BINDING
SUBUNIT HSLU
(Haemophilus
influenzae) 		5 / 12 LEU A  73
ILE A   9
GLU A  12
LEU A  13
ASP A  14
 None
 1.20A 3ko0M-1kyiA:
0.0
3ko0N-1kyiA:
undetectable
3ko0O-1kyiA:
undetectable
3ko0P-1kyiA:
undetectable		 3ko0M-1kyiA:
12.19
3ko0N-1kyiA:
12.19
3ko0O-1kyiA:
12.19
3ko0P-1kyiA:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PY4_A_TYLA598_1
(LACTOPEROXIDASE)		 1kyi ATP-DEPENDENT HSL
PROTEASE ATP-BINDING
SUBUNIT HSLU
(Haemophilus
influenzae) 		4 / 5 GLN A  15
HIS A  16
ARG A  69
GLU A  12
 None
 1.20A 3py4A-1kyiA:
0.0		 3py4A-1kyiA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QF1_A_PZEA6951_1
(LACTOPEROXIDASE)		 1kyi ATP-DEPENDENT HSL
PROTEASE ATP-BINDING
SUBUNIT HSLU
(Haemophilus
influenzae) 		3 / 3 HIS A  16
ARG A  69
GLU A  12
 None
 0.86A 3qf1A-1kyiA:
0.0		 3qf1A-1kyiA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R4X_A_PZAA597_0
(LACTOPEROXIDASE)		 1kyi ATP-DEPENDENT HSL
PROTEASE ATP-BINDING
SUBUNIT HSLU
(Haemophilus
influenzae) 		4 / 5 GLN A  15
HIS A  16
ARG A  69
GLU A  12
 None
 1.19A 3r4xA-1kyiA:
0.0		 3r4xA-1kyiA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R55_A_PZAA597_0
(LACTOPEROXIDASE)		 1kyi ATP-DEPENDENT HSL
PROTEASE ATP-BINDING
SUBUNIT HSLU
(Haemophilus
influenzae) 		4 / 5 GLN A  15
HIS A  16
ARG A  69
GLU A  12
 None
 1.24A 3r55A-1kyiA:
0.0		 3r55A-1kyiA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T8N_D_EDTD135_0
(STEROID
DELTA-ISOMERASE)		 1kyi ATP-DEPENDENT HSL
PROTEASE ATP-BINDING
SUBUNIT HSLU
(Haemophilus
influenzae) 		5 / 11 THR A  49
PRO A  50
THR A 300
GLY A 288
ARG A 326
 None
 1.47A 3t8nD-1kyiA:
0.0
3t8nF-1kyiA:
0.0		 3t8nD-1kyiA:
15.28
3t8nF-1kyiA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T8N_D_EDTD135_0
(STEROID
DELTA-ISOMERASE)		 1kyi ATP-DEPENDENT HSL
PROTEASE ATP-BINDING
SUBUNIT HSLU
(Haemophilus
influenzae) 		5 / 11 THR A 300
GLY A 288
ARG A 326
THR A  49
PRO A  50
 None
 1.48A 3t8nD-1kyiA:
0.0
3t8nF-1kyiA:
0.0		 3t8nD-1kyiA:
15.28
3t8nF-1kyiA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IG5_A_MMZA616_1
(LACTOPEROXIDASE)		 1kyi ATP-DEPENDENT HSL
PROTEASE ATP-BINDING
SUBUNIT HSLU
(Haemophilus
influenzae) 		4 / 5 GLN A  15
HIS A  16
ARG A  69
GLU A  12
 None
 1.15A 4ig5A-1kyiA:
0.0		 4ig5A-1kyiA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IG5_B_MMZB617_1
(LACTOPEROXIDASE)		 1kyi ATP-DEPENDENT HSL
PROTEASE ATP-BINDING
SUBUNIT HSLU
(Haemophilus
influenzae) 		4 / 5 GLN A  15
HIS A  16
ARG A  69
GLU A  12
 None
 1.18A 4ig5B-1kyiA:
0.0		 4ig5B-1kyiA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_B_3CJB607_1
(LACTOPEROXIDASE)		 1kyi ATP-DEPENDENT HSL
PROTEASE ATP-BINDING
SUBUNIT HSLU
(Haemophilus
influenzae) 		3 / 3 GLN A  15
HIS A  16
ARG A  69
 None
 1.18A 4qyqB-1kyiA:
0.0		 4qyqB-1kyiA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_C_3CJC607_1
(LACTOPEROXIDASE)		 1kyi ATP-DEPENDENT HSL
PROTEASE ATP-BINDING
SUBUNIT HSLU
(Haemophilus
influenzae) 		4 / 6 GLN A  15
HIS A  16
ARG A  69
GLU A  12
 None
 1.32A 4qyqC-1kyiA:
0.4		 4qyqC-1kyiA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_D_3CJD607_1
(LACTOPEROXIDASE)		 1kyi ATP-DEPENDENT HSL
PROTEASE ATP-BINDING
SUBUNIT HSLU
(Haemophilus
influenzae) 		4 / 4 GLN A  15
HIS A  16
ARG A  69
GLU A  12
 None
 1.21A 4qyqD-1kyiA:
0.0		 4qyqD-1kyiA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FF1_A_MMZA601_1
(LACTOPEROXIDASE)		 1kyi ATP-DEPENDENT HSL
PROTEASE ATP-BINDING
SUBUNIT HSLU
(Haemophilus
influenzae) 		4 / 5 GLN A  15
HIS A  16
ARG A  69
GLU A  12
 None
 1.19A 5ff1A-1kyiA:
0.0		 5ff1A-1kyiA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FF1_A_MMZA602_1
(LACTOPEROXIDASE)		 1kyi ATP-DEPENDENT HSL
PROTEASE ATP-BINDING
SUBUNIT HSLU
(Haemophilus
influenzae) 		4 / 5 GLN A  15
HIS A  16
ARG A  69
GLU A  12
 None
 1.19A 5ff1A-1kyiA:
0.0		 5ff1A-1kyiA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FF1_B_MMZB601_1
(LACTOPEROXIDASE)		 1kyi ATP-DEPENDENT HSL
PROTEASE ATP-BINDING
SUBUNIT HSLU
(Haemophilus
influenzae) 		4 / 5 GLN A  15
HIS A  16
ARG A  69
GLU A  12
 None
 1.18A 5ff1B-1kyiA:
0.0		 5ff1B-1kyiA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FF1_B_MMZB613_1
(LACTOPEROXIDASE)		 1kyi ATP-DEPENDENT HSL
PROTEASE ATP-BINDING
SUBUNIT HSLU
(Haemophilus
influenzae) 		4 / 5 GLN A  15
HIS A  16
ARG A  69
GLU A  12
 None
 1.18A 5ff1B-1kyiA:
0.0		 5ff1B-1kyiA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPW_C_3CJC609_1
(LACTOPEROXIDASE)		 1kyi ATP-DEPENDENT HSL
PROTEASE ATP-BINDING
SUBUNIT HSLU
(Haemophilus
influenzae) 		4 / 6 GLN A  15
HIS A  16
ARG A  69
GLU A  12
 None
 1.32A 5hpwC-1kyiA:
0.4		 5hpwC-1kyiA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPW_D_3CJD609_1
(LACTOPEROXIDASE)		 1kyi ATP-DEPENDENT HSL
PROTEASE ATP-BINDING
SUBUNIT HSLU
(Haemophilus
influenzae) 		4 / 4 GLN A  15
HIS A  16
ARG A  69
GLU A  12
 None
 1.21A 5hpwD-1kyiA:
0.0		 5hpwD-1kyiA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_C_URFC301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 1kyi ATP-DEPENDENT HSL
PROTEASE ATP-BINDING
SUBUNIT HSLU
(Haemophilus
influenzae) 		3 / 3 ARG A  45
HIS A  46
ARG A  37
 None
 1.15A 5iaoC-1kyiA:
0.4		 5iaoC-1kyiA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_F_URFF301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 1kyi ATP-DEPENDENT HSL
PROTEASE ATP-BINDING
SUBUNIT HSLU
(Haemophilus
influenzae) 		3 / 3 ARG A  45
HIS A  46
ARG A  37
 None
 1.15A 5iaoF-1kyiA:
0.4		 5iaoF-1kyiA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1kyi ATP-DEPENDENT HSL
PROTEASE ATP-BINDING
SUBUNIT HSLU
(Haemophilus
influenzae) 		6 / 12 ILE A 253
GLY A 252
ALA A  71
ILE A  66
ALA A  67
VAL A  27
 None
 1.47A 5n0tB-1kyiA:
1.8		 5n0tB-1kyiA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_1
(CYTOCHROME P450 3A5)		 1kyi ATP-DEPENDENT HSL
PROTEASE ATP-BINDING
SUBUNIT HSLU
(Haemophilus
influenzae) 		5 / 12 LEU A 327
PHE A 255
GLY A 252
ILE A 259
ALA A  83
 None
 0.89A 5veuH-1kyiA:
0.0		 5veuH-1kyiA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_D_CVID301_1
(REGULATORY PROTEIN
TETR)		 1kyi ATP-DEPENDENT HSL
PROTEASE ATP-BINDING
SUBUNIT HSLU
(Haemophilus
influenzae) 		4 / 8 GLN A  20
GLY A  62
ILE A 344
GLN A 355
 None
ATP  A 450 (-3.5A)
ATP  A 450 (-4.0A)
None
 1.01A 5vlmD-1kyiA:
0.0		 5vlmD-1kyiA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_G_EY4G501_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 1kyi ATP-DEPENDENT HSL
PROTEASE ATP-BINDING
SUBUNIT HSLU
(Haemophilus
influenzae) 		4 / 7 VAL A 254
PRO A  50
ILE A 100
THR A 104
 None
 0.76A 6cduF-1kyiA:
0.0
6cduG-1kyiA:
0.0		 6cduF-1kyiA:
22.85
6cduG-1kyiA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		 1kyi ATP-DEPENDENT HSL
PROTEASE ATP-BINDING
SUBUNIT HSLU
(Haemophilus
influenzae) 		3 / 3 ASP A  14
ASP A 340
ASN A 390
 None
 0.84A 6gngB-1kyiA:
undetectable		 6gngB-1kyiA:
25.00