SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1kyo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4001_1
(SERUM ALBUMIN)		 1kyo LIGHT CHAIN (VL) OF
FV-FRAGMENT
(Mus
musculus) 		4 / 5 ARG K  24
ALA K  25
ASP K  70
GLY K  68
 None
 0.98A 1e7bA-1kyoK:
undetectable		 1e7bA-1kyoK:
10.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1H8S_A_AICA1000_1
(MUTANT AL2 6E7P9G)		 1kyo HEAVY CHAIN (VH) OF
FV-FRAGMENT
LIGHT CHAIN (VL) OF
FV-FRAGMENT
(Mus
musculus) 		6 / 12 TYR K  36
GLN K  89
PHE K  98
ASN J  36
ALA J  97
TRP J 112
 None
 0.89A 1h8sA-1kyoK:
20.2		 1h8sA-1kyoK:
58.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IGJ_B_DGXB228_1
(IGG2A-KAPPA 26-10
FAB (LIGHT CHAIN)
IGG2A-KAPPA 26-10
FAB (HEAVY CHAIN))		 1kyo HEAVY CHAIN (VH) OF
FV-FRAGMENT
LIGHT CHAIN (VL) OF
FV-FRAGMENT
(Mus
musculus) 		5 / 10 TYR K  36
TYR J  34
ASN J  36
SER J  99
MET J 109
 None
 0.84A 1igjA-1kyoK:
20.0
1igjB-1kyoK:
14.4		 1igjA-1kyoK:
56.25
1igjB-1kyoK:
19.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IGJ_B_DGXB228_1
(IGG2A-KAPPA 26-10
FAB (LIGHT CHAIN)
IGG2A-KAPPA 26-10
FAB (HEAVY CHAIN))		 1kyo HEAVY CHAIN (VH) OF
FV-FRAGMENT
LIGHT CHAIN (VL) OF
FV-FRAGMENT
(Mus
musculus) 		5 / 10 TYR K  36
TYR J  34
ASN J  36
TYR J  51
MET J 109
 None
 0.78A 1igjA-1kyoK:
20.0
1igjB-1kyoK:
14.4		 1igjA-1kyoK:
56.25
1igjB-1kyoK:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHO_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1kyo HEAVY CHAIN (VH) OF
FV-FRAGMENT
(Mus
musculus) 		5 / 9 GLY J 115
GLY J   8
LEU J  20
GLU J   6
GLY J  10
 None
 1.20A 1jhoA-1kyoJ:
undetectable		 1jhoA-1kyoJ:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHR_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1kyo HEAVY CHAIN (VH) OF
FV-FRAGMENT
(Mus
musculus) 		5 / 9 GLY J 115
GLY J   8
LEU J  20
GLU J   6
GLY J  10
 None
 1.21A 1jhrA-1kyoJ:
undetectable		 1jhrA-1kyoJ:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHY_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1kyo HEAVY CHAIN (VH) OF
FV-FRAGMENT
(Mus
musculus) 		5 / 9 GLY J 115
GLY J   8
LEU J  20
GLU J   6
GLY J  10
 None
 1.15A 1jhyA-1kyoJ:
undetectable		 1jhyA-1kyoJ:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L4N_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1kyo HEAVY CHAIN (VH) OF
FV-FRAGMENT
(Mus
musculus) 		5 / 9 GLY J 115
GLY J   8
LEU J  20
GLU J   6
GLY J  10
 None
 1.20A 1l4nA-1kyoJ:
undetectable		 1l4nA-1kyoJ:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5K_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1kyo HEAVY CHAIN (VH) OF
FV-FRAGMENT
(Mus
musculus) 		5 / 9 GLY J 115
GLY J   8
LEU J  20
GLU J   6
GLY J  10
 None
 1.20A 1l5kA-1kyoJ:
undetectable		 1l5kA-1kyoJ:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5L_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1kyo HEAVY CHAIN (VH) OF
FV-FRAGMENT
(Mus
musculus) 		5 / 9 GLY J 115
GLY J   8
LEU J  20
GLU J   6
GLY J  10
 None
 1.23A 1l5lA-1kyoJ:
undetectable		 1l5lA-1kyoJ:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5M_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1kyo HEAVY CHAIN (VH) OF
FV-FRAGMENT
(Mus
musculus) 		5 / 9 GLY J 115
GLY J   8
LEU J  20
GLU J   6
GLY J  10
 None
 1.23A 1l5mA-1kyoJ:
undetectable		 1l5mA-1kyoJ:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 1kyo HEAVY CHAIN (VH) OF
FV-FRAGMENT
(Mus
musculus) 		5 / 12 GLN J  78
THR J  21
ARG J  98
ILE J  29
PHE J  79
 None
 1.41A 2vdyA-1kyoJ:
0.5		 2vdyA-1kyoJ:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_C_HCYC1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 1kyo HEAVY CHAIN (VH) OF
FV-FRAGMENT
(Mus
musculus) 		5 / 12 GLN J  78
THR J  21
ARG J  98
ILE J  29
PHE J  79
 None
 1.46A 4c49C-1kyoJ:
0.4		 4c49C-1kyoJ:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQI_A_NIOA403_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1kyo HEAVY CHAIN (VH) OF
FV-FRAGMENT
(Mus
musculus) 		5 / 9 GLY J 115
GLY J   8
LEU J  20
GLU J   6
GLY J  10
 None
 1.19A 4kqiA-1kyoJ:
undetectable		 4kqiA-1kyoJ:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1kyo HEAVY CHAIN (VH) OF
FV-FRAGMENT
(Mus
musculus) 		5 / 12 LEU J  18
SER J  17
VAL J  12
GLY J  10
ALA J   9
 None
 1.17A 5ikrA-1kyoJ:
undetectable		 5ikrA-1kyoJ:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LAK_I_BEZI1_0
(3CL PROTEASE
BEZ-TYR-TYR-ASN-ECC
PEPTIDE INHIBITOR)		 1kyo HEAVY CHAIN (VH) OF
FV-FRAGMENT
(Mus
musculus) 		3 / 3 SER J 103
TYR J 102
TYR J 101
 None
 0.81A 5lakA-1kyoJ:
0.6
5lakI-1kyoJ:
undetectable		 5lakA-1kyoJ:
15.48
5lakI-1kyoJ:
5.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LAK_J_BEZJ1_0
(3CL PROTEASE
BEZ-TYR-TYR-ASN-ECC
PEPTIDE INHIBITOR)		 1kyo HEAVY CHAIN (VH) OF
FV-FRAGMENT
(Mus
musculus) 		3 / 3 SER J 103
TYR J 102
TYR J 101
 None
 0.80A 5lakC-1kyoJ:
0.0
5lakJ-1kyoJ:
undetectable		 5lakC-1kyoJ:
15.48
5lakJ-1kyoJ:
5.13