SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1kyq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_A_PFNA1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 1kyq SIROHEME
BIOSYNTHESIS PROTEIN
MET8
(Saccharomyces
cerevisiae) 		4 / 6 SER A  91
LYS A  94
GLU A  96
TYR A  97
 None
 1.28A 2x7hA-1kyqA:
5.6		 2x7hA-1kyqA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A25_A_SAMA279_0
(UNCHARACTERIZED
PROTEIN PH0793)		 1kyq SIROHEME
BIOSYNTHESIS PROTEIN
MET8
(Saccharomyces
cerevisiae) 		5 / 12 ASN A 138
ARG A  28
PHE A  93
GLY A  20
ILE A  89
 None
None
None
NAD  A 800 (-3.5A)
None
 1.42A 3a25A-1kyqA:
5.5		 3a25A-1kyqA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG306_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 1kyq SIROHEME
BIOSYNTHESIS PROTEIN
MET8
(Saccharomyces
cerevisiae) 		3 / 3 ARG A  72
ARG A  15
ASP A  99
 None
 0.91A 3wipG-1kyqA:
0.0
3wipH-1kyqA:
undetectable		 3wipG-1kyqA:
22.18
3wipH-1kyqA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_A_REAA501_1
(RETINOIC ACID
RECEPTOR BETA)		 1kyq SIROHEME
BIOSYNTHESIS PROTEIN
MET8
(Saccharomyces
cerevisiae) 		5 / 11 PHE A 131
LEU A 126
ILE A 123
LEU A  17
LEU A 100
 None
 1.10A 4dm8A-1kyqA:
undetectable		 4dm8A-1kyqA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVD_A_SAMA502_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 1kyq SIROHEME
BIOSYNTHESIS PROTEIN
MET8
(Saccharomyces
cerevisiae) 		5 / 12 ILE A  19
GLY A  20
PRO A  44
PHE A  93
ARG A  28
 None
NAD  A 800 (-3.5A)
NAD  A 800 (-3.7A)
None
None
 1.01A 4rvdA-1kyqA:
3.9		 4rvdA-1kyqA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVG_A_SAMA503_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 1kyq SIROHEME
BIOSYNTHESIS PROTEIN
MET8
(Saccharomyces
cerevisiae) 		5 / 12 ILE A  19
GLY A  20
PRO A  44
PHE A  93
ARG A  28
 None
NAD  A 800 (-3.5A)
NAD  A 800 (-3.7A)
None
None
 0.98A 4rvgA-1kyqA:
4.0		 4rvgA-1kyqA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_1
(ADENOSYLHOMOCYSTEINA
SE)		 1kyq SIROHEME
BIOSYNTHESIS PROTEIN
MET8
(Saccharomyces
cerevisiae) 		3 / 3 LEU A 163
GLN A   6
LYS A  31
 None
 0.96A 6exiB-1kyqA:
4.3		 6exiB-1kyqA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_0
(ADENOSYLHOMOCYSTEINA
SE)		 1kyq SIROHEME
BIOSYNTHESIS PROTEIN
MET8
(Saccharomyces
cerevisiae) 		3 / 3 LEU A 163
GLN A   6
LYS A  31
 None
 0.90A 6exiA-1kyqA:
4.0		 6exiA-1kyqA:
21.67