SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1kyw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FPQ_A_SAMA1699_0
(ISOLIQUIRITIGENIN
2'-O-METHYLTRANSFERA
SE)		 1kyw CAFFEIC ACID
3-O-METHYLTRANSFERAS
E
(Medicago
sativa) 		5 / 10 ASP A 231
LEU A 232
VAL A 235
ASP A 251
TRP A 271
 None
 1.40A 1fpqA-1kywA:
25.5		 1fpqA-1kywA:
49.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FPQ_A_SAMA1699_0
(ISOLIQUIRITIGENIN
2'-O-METHYLTRANSFERA
SE)		 1kyw CAFFEIC ACID
3-O-METHYLTRANSFERAS
E
(Medicago
sativa) 		5 / 10 GLY A 208
ASP A 231
LEU A 232
VAL A 235
ASP A 251
 None
 0.33A 1fpqA-1kywA:
25.5		 1fpqA-1kywA:
49.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA140_0
(LYSOZYME C)		 1kyw CAFFEIC ACID
3-O-METHYLTRANSFERAS
E
(Medicago
sativa) 		3 / 3 ASN A 324
ALA A 162
ASN A 155
 None
 0.74A 1n4fA-1kywA:
undetectable		 1n4fA-1kywA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P9G_A_ACTA42_0
(EAFP 2)		 1kyw CAFFEIC ACID
3-O-METHYLTRANSFERAS
E
(Medicago
sativa) 		3 / 3 CYH A 268
ARG A 330
CYH A 276
 None
 1.41A 1p9gA-1kywA:
0.0		 1p9gA-1kywA:
7.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_B_SAMB9635_0
(PROTEIN RDMB)		 1kyw CAFFEIC ACID
3-O-METHYLTRANSFERAS
E
(Medicago
sativa) 		5 / 12 GLY A 208
GLY A 209
GLY A 210
LEU A 232
ASP A 251
 None
 0.30A 1xdsB-1kywA:
25.0		 1xdsB-1kywA:
25.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_1
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 1kyw CAFFEIC ACID
3-O-METHYLTRANSFERAS
E
(Medicago
sativa) 		4 / 5 ALA A 213
ASP A 231
ASP A 251
ASP A 206
 None
 1.13A 2nyuB-1kywA:
11.1		 2nyuB-1kywA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UYQ_A_SAMA1311_0
(HYPOTHETICAL PROTEIN
ML2640)		 1kyw CAFFEIC ACID
3-O-METHYLTRANSFERAS
E
(Medicago
sativa) 		4 / 7 GLY A 210
ASP A 231
VAL A 235
ASP A 251
 None
 0.66A 2uyqA-1kywA:
10.2		 2uyqA-1kywA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1kyw CAFFEIC ACID
3-O-METHYLTRANSFERAS
E
(Medicago
sativa) 		4 / 7 ILE A 294
PHE A 198
MET A 188
THR A 187
 None
 1.05A 2zxwN-1kywA:
0.3
2zxwW-1kywA:
0.0		 2zxwN-1kywA:
22.20
2zxwW-1kywA:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1kyw CAFFEIC ACID
3-O-METHYLTRANSFERAS
E
(Medicago
sativa) 		4 / 7 ILE A 294
PHE A 198
MET A 188
THR A 187
 None
 1.02A 3ag2N-1kywA:
0.0
3ag2W-1kywA:
0.0		 3ag2N-1kywA:
22.20
3ag2W-1kywA:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1kyw CAFFEIC ACID
3-O-METHYLTRANSFERAS
E
(Medicago
sativa) 		4 / 7 ILE A 294
PHE A 198
MET A 188
THR A 187
 None
 1.05A 3ag4N-1kywA:
0.0
3ag4W-1kywA:
0.0		 3ag4N-1kywA:
22.20
3ag4W-1kywA:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1kyw CAFFEIC ACID
3-O-METHYLTRANSFERAS
E
(Medicago
sativa) 		4 / 6 LEU A  66
ILE A  57
ALA A  39
LEU A  40
 None
 0.90A 3kk6B-1kywA:
undetectable		 3kk6B-1kywA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_1
(CYTOCHROME P450 3A4)		 1kyw CAFFEIC ACID
3-O-METHYLTRANSFERAS
E
(Medicago
sativa) 		5 / 12 PHE A 344
ILE A 256
PHE A 279
ALA A 296
GLU A 360
 None
 0.83A 3nxuA-1kywA:
0.0		 3nxuA-1kywA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1kyw CAFFEIC ACID
3-O-METHYLTRANSFERAS
E
(Medicago
sativa) 		3 / 3 GLY A 210
ASP A 231
ASP A 251
 None
 0.47A 3ou7C-1kywA:
14.5		 3ou7C-1kywA:
19.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PGH_A_SAMA401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 1kyw CAFFEIC ACID
3-O-METHYLTRANSFERAS
E
(Medicago
sativa) 		6 / 11 SER A 184
GLY A 208
ASP A 231
LEU A 232
VAL A 235
LYS A 265
 None
 1.09A 4pghA-1kywA:
43.2		 4pghA-1kywA:
59.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PGH_A_SAMA401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 1kyw CAFFEIC ACID
3-O-METHYLTRANSFERAS
E
(Medicago
sativa) 		10 / 11 SER A 184
GLY A 208
GLY A 209
ASP A 231
LEU A 232
VAL A 235
ASP A 251
MET A 252
LYS A 265
ILE A 267
 None
 0.56A 4pghA-1kywA:
43.2		 4pghA-1kywA:
59.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PGH_B_SAMB401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 1kyw CAFFEIC ACID
3-O-METHYLTRANSFERAS
E
(Medicago
sativa) 		5 / 12 ASP A 231
LEU A 232
ASP A 251
ASP A 270
TRP A 271
 None
 1.38A 4pghB-1kywA:
43.2		 4pghB-1kywA:
59.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PGH_B_SAMB401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 1kyw CAFFEIC ACID
3-O-METHYLTRANSFERAS
E
(Medicago
sativa) 		10 / 12 SER A 184
ASP A 206
GLY A 208
ASP A 231
LEU A 232
ASP A 251
MET A 252
LYS A 265
ILE A 267
ASP A 270
 None
 0.53A 4pghB-1kywA:
43.2		 4pghB-1kywA:
59.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PGH_C_SAMC401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 1kyw CAFFEIC ACID
3-O-METHYLTRANSFERAS
E
(Medicago
sativa) 		5 / 11 ASP A 231
LEU A 232
VAL A 235
ASP A 251
TRP A 271
 None
 1.40A 4pghC-1kywA:
42.6		 4pghC-1kywA:
59.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PGH_C_SAMC401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 1kyw CAFFEIC ACID
3-O-METHYLTRANSFERAS
E
(Medicago
sativa) 		5 / 11 GLY A 209
ASP A 231
VAL A 235
LYS A 265
TRP A 266
 None
 1.48A 4pghC-1kywA:
42.6		 4pghC-1kywA:
59.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PGH_C_SAMC401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 1kyw CAFFEIC ACID
3-O-METHYLTRANSFERAS
E
(Medicago
sativa) 		10 / 11 SER A 184
GLY A 208
ASP A 231
LEU A 232
VAL A 235
ASP A 251
MET A 252
LYS A 265
TRP A 266
ILE A 267
 None
 0.55A 4pghC-1kywA:
42.6		 4pghC-1kywA:
59.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PGH_D_SAMD401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 1kyw CAFFEIC ACID
3-O-METHYLTRANSFERAS
E
(Medicago
sativa) 		9 / 12 SER A 184
GLY A 208
GLY A 209
ASP A 231
LEU A 232
ASP A 251
PHE A 253
LYS A 265
ILE A 267
 None
 0.85A 4pghD-1kywA:
42.6		 4pghD-1kywA:
59.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PGH_D_SAMD401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 1kyw CAFFEIC ACID
3-O-METHYLTRANSFERAS
E
(Medicago
sativa) 		9 / 12 SER A 184
GLY A 208
GLY A 209
ASP A 231
LEU A 232
MET A 252
PHE A 253
LYS A 265
ILE A 267
 None
 0.78A 4pghD-1kywA:
42.6		 4pghD-1kywA:
59.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PGH_D_SAMD401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 1kyw CAFFEIC ACID
3-O-METHYLTRANSFERAS
E
(Medicago
sativa) 		6 / 12 SER A 184
GLY A 210
ASP A 231
LEU A 232
MET A 252
PHE A 253
 None
 1.46A 4pghD-1kywA:
42.6		 4pghD-1kywA:
59.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_0
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 1kyw CAFFEIC ACID
3-O-METHYLTRANSFERAS
E
(Medicago
sativa) 		5 / 12 LEU A 192
ILE A 225
ILE A 191
ILE A 294
PHE A 263
 None
 1.11A 4rp8C-1kywA:
0.0		 4rp8C-1kywA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YJI_A_TYLA502_1
(ARYL ACYLAMIDASE)		 1kyw CAFFEIC ACID
3-O-METHYLTRANSFERAS
E
(Medicago
sativa) 		4 / 7 THR A 211
GLY A 209
GLY A 208
ILE A 267
 None
 0.73A 4yjiA-1kywA:
0.0		 4yjiA-1kywA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_J_CHDJ102_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1kyw CAFFEIC ACID
3-O-METHYLTRANSFERAS
E
(Medicago
sativa) 		4 / 7 ILE A  62
LEU A  77
THR A  91
LEU A  90
 None
 0.96A 5b1aA-1kywA:
0.3
5b1aJ-1kywA:
undetectable		 5b1aA-1kywA:
22.20
5b1aJ-1kywA:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1kyw CAFFEIC ACID
3-O-METHYLTRANSFERAS
E
(Medicago
sativa) 		4 / 7 ILE A  62
LEU A  77
THR A  91
LEU A  90
 None
 0.97A 5b3sA-1kywA:
0.0
5b3sJ-1kywA:
undetectable		 5b3sA-1kywA:
22.20
5b3sJ-1kywA:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_1
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 1kyw CAFFEIC ACID
3-O-METHYLTRANSFERAS
E
(Medicago
sativa) 		4 / 4 ASP A 206
GLY A 210
ASP A 231
ASP A 251
 None
 0.76A 5e72A-1kywA:
11.0		 5e72A-1kywA:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QSA615_1
(SERUM ALBUMIN)		 1kyw CAFFEIC ACID
3-O-METHYLTRANSFERAS
E
(Medicago
sativa) 		4 / 8 LEU A 204
VAL A 207
LEU A 287
ILE A 256
 None
 1.01A 5v0vA-1kywA:
0.0		 5v0vA-1kywA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_1
(CYTOCHROME P450 3A4)		 1kyw CAFFEIC ACID
3-O-METHYLTRANSFERAS
E
(Medicago
sativa) 		5 / 12 PHE A 344
ILE A 256
PHE A 279
ALA A 296
GLU A 360
 None
 0.96A 5vceA-1kywA:
undetectable		 5vceA-1kywA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1kyw CAFFEIC ACID
3-O-METHYLTRANSFERAS
E
(Medicago
sativa) 		4 / 5 PHE A 347
PHE A 361
LEU A 280
PHE A 279
 None
 1.35A 5wauC-1kywA:
0.0
5wauJ-1kywA:
0.0		 5wauC-1kywA:
22.25
5wauJ-1kywA:
10.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6I5Z_D_SAMD401_0
(O-METHYLTRANSFERASE
1)		 1kyw CAFFEIC ACID
3-O-METHYLTRANSFERAS
E
(Medicago
sativa) 		11 / 11 SER A 184
GLY A 208
GLY A 210
ASP A 231
LEU A 232
VAL A 235
ASP A 251
MET A 252
LYS A 265
TRP A 266
ASP A 270
 None
 0.91A 6i5zD-1kywA:
33.7		 6i5zD-1kywA:
41.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6I5Z_D_SAMD401_0
(O-METHYLTRANSFERASE
1)		 1kyw CAFFEIC ACID
3-O-METHYLTRANSFERAS
E
(Medicago
sativa) 		9 / 11 SER A 184
GLY A 209
ASP A 231
LEU A 232
ASP A 251
MET A 252
LYS A 265
TRP A 266
ASP A 270
 None
 0.99A 6i5zD-1kywA:
33.7		 6i5zD-1kywA:
41.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 1kyw CAFFEIC ACID
3-O-METHYLTRANSFERAS
E
(Medicago
sativa) 		5 / 12 ASP A 206
GLY A 208
GLY A 210
VAL A 214
ASP A 251
 None
 0.59A 6nj9K-1kywA:
9.1		 6nj9K-1kywA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 1kyw CAFFEIC ACID
3-O-METHYLTRANSFERAS
E
(Medicago
sativa) 		5 / 12 ASP A 206
GLY A 208
VAL A 214
ASP A 251
PHE A 263
 None
 0.98A 6nj9K-1kywA:
9.1		 6nj9K-1kywA:
22.12